A5030056876- Drug-Induced Hepatotoxicity and Protection
- Chemotherapy-induced organ toxicity mitigation
- Virus-based gene therapy research
- Curcumin's Biomedical Applications
- Pharmacogenetics and Drug Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Stress Responses and Cortisol
- Reproductive Biology and Fertility
- Pharmacological Effects of Natural Compounds
- Nigella sativa pharmacological applications
- Animal Genetics and Reproduction
- Pharmacological Effects and Toxicity Studies
- Ginger and Zingiberaceae research
- Natural Antidiabetic Agents Studies
- Tryptophan and brain disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Phytochemicals and Antioxidant Activities
- Berberine and alkaloids research
- Advanced Glycation End Products research
- Flavonoids in Medical Research
- Bioactive natural compounds
- Bioactive Compounds and Antitumor Agents
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer Treatment and Pharmacology
University of Ibadan
2020-2024
KolaDaisi University
2020-2023
Instituto Valenciano de Investigaciones Agrarias
2022
Universidade Federal de Viçosa
2022
Universidade Federal do Rio Grande do Sul
2022
Hashemite University
2021
McPherson University
2017-2020
Bowen University
2016
Abstract Background Doxorubicin (DOX) induces toxicity in many tissues/organs, including the heart, kidney and so on. This study was designed to evaluate modulatory effects of protocatechuic acid (PCA) against DOX-induced nephrotoxicity rats. Animals were randomly grouped into five groups. Methods Group 1 served as normal control (CTR). A single dose DOX at 20 mg/kg administered intraperitoneally (i.p.) animals 2. Groups 3 4 pretreated with PCA for 5 days (doses 10 body weight, respectively)...
Nitric Oxide (NO) is an essential signaling molecule with diverse physiological functions in humans. The steady-state concentration and site of production nitric oxide determine its effects biological systems. human cells are exposed to both beneficial harmful NO. These dual NO could depend on local the cells. Additionally, rate synthesis, translocation, direct interaction other molecules, signals contribute biochemical In this review, role NO, particularly health disease as touching cell...
Protocatechuic acid (PCA) possesses numerous pharmacological activities, including antioxidative and anti-inflammatory activities. This study seeks to investigate its underlying mechanism of action in the liver brain toxicity induced by CCl4 male albino rats.Rats were given PCA at 10 20 mg/kg daily orally as a pretreatment for seven days. A single injection was 2 h later induce toxicity.CCl4 moderately elevated activities alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase...
Elevation of phosphodiesterase-5 (PDE5) activity converts cyclic guanosine monophosphate (cGMP) to 5'-GMP, a mechanism that could be associated with drug-mediated hepatotoxicity. This study investigated whether selective inhibition PDE5 by sildenafil offer protection against hepatotoxicity induced carbon tetrachloride (CCl4).CCl4 (0.5 mL/kg) was administered intraperitoneally induce The control group received normal saline. Sildenafil (5 mg, 10 and 20 mg/kg, p.o.) CCl4-treated rats.CCl4...
Effect of leave extract Ocimum basilicum on deltamethrin induced nephrotoxicity and oxidative stress in albino ratsSaber A. Sakr, Wael M. Al-Amoudi
Plants have been used for centuries as a treatment various medical conditions, with over 80% of the population relying on them healthcare. Curcumin, an aromatic spice from Curcuma longa L., is significant contributor to this list. Curcumin non-toxic and has numerous benefits, including anti-inflammatory, antiseptic, antioxidant, analgesic properties. It contains high number antioxidants, which can help treat ailments, digestion, smallpox, skin cancer, wound healing, body weight, neurological...
This study investigated the effect of selective inhibition phosphodiesterase-5 on hepatotoxicity and genotoxicity induced by adriamycin in rats. Thirty male Wistar rats (150 - 250 g) were randomly assigned into six groups 5 rats/group. Negative, positive sildenafil controls received physiological saline (10 ml/kg, p.o.), (20 mg/kg, i.p.) p.o.) respectively. Three separate pretreated with (5, 10 20 mg/kg respectively) prior to injection. Adriamycin increased activities aspartate...
Background: Natural products or naturally derived compounds are invaluable to human and animal lives either for nutritional value medicinal purposes. Indeed, natural including extracts containing polychemical mixtures play a leading role in the discovery development of drugs. However, increasing interest medicines is also attracting growing concern about safety medications. Objective: In present study, we evaluated several vitro cytotoxicity mammalian cells. Methods: A total 54 were...
Hypoxia-inducible factors (HIFs) are transcription that initiate the expression of cellular processes to cope with hypoxic conditions. HIFs principal regulators adaptation, regulating gene involved in glycolysis, erythropoiesis, angiogenesis, proliferation, and stem cell function under low O 2 . may play a pivotal role tumor survival metastasis cancer formation growth. Likewise, key microbial pathogenesis, particularly host-pathogen interaction. Because HIF-1alpha plays biology infections,...