A5018118045- Organoselenium and organotellurium chemistry
- Selenium in Biological Systems
- Sulfur Compounds in Biology
- Organic Chemistry Cycloaddition Reactions
- Mercury impact and mitigation studies
- Free Radicals and Antioxidants
- Redox biology and oxidative stress
- Pesticide Exposure and Toxicity
- Genomics, phytochemicals, and oxidative stress
- Tryptophan and brain disorders
- Antioxidant Activity and Oxidative Stress
- Biochemical effects in animals
- Anesthesia and Neurotoxicity Research
- Phytochemical Studies and Bioactivities
- Phytochemicals and Antioxidant Activities
- Heavy Metal Exposure and Toxicity
- Nuts composition and effects
- Education and Public Policy
- Phytochemistry and Biological Activities
- Human Health and Disease
- Science and Science Education
- Dyeing and Modifying Textile Fibers
- Medicinal Plant Extracts Effects
- Medicinal Plants and Neuroprotection
- Bioactive Natural Diterpenoids Research
European Union of Medical Specialists
2024
Universidade Estadual de Mato Grosso do Sul
2024
Universidade Federal de Santa Maria
2009-2023
There are several specific inflammatory and oxidative correlates among patients with hypothyroidism, but most studies cross-sectional do not evaluate the change in parameters during treatment. The aim of this study was to investigate effect levothyroxine replacement therapy on biomarkers stress (OS) systemic inflammation hypothyroidism.In prospective open-label study, 17 recently diagnosed primary hypothyroidism due Hashimoto's thyroiditis who were taking included. following measured before...
We evaluated the activity and expression of antioxidant enzymes in cerebellum cortex Swiss adult male mice exposed to methylmercury (MeHg) drinking water (40mg/L) during 21 days. The glutathione peroxidase (GPx), reductase (GR), S-transferase (GST), catalase (CAT), superoxide dismutase (SOD) thioredoxin (TrxR) were determined spectrophotometrically. (protein levels) GPx1 GPx4 isoforms, TrxR1 as well heat shock protein 70 (HSP70) using specific antibodies normalized by actin levels. exposure...
Organochalcogens, particularly ebselen, have been used in experimental and clinical trials with borderline efficacy. (PhSe) 2 (PhTe) are the simplest of diaryl dichalcogenides share ebselen pharmacological properties. In view concerns use mammals studies great number new organochalcogens potential properties that synthesized, it becomes important to develop screening protocols select compounds worth be tested vivo . This study investigated possible isolated human white cells as a preliminary...
Organic and inorganic forms of mercury are highly neurotoxic environmental contaminants. The exact mechanisms involved in neurotoxicity still unclear. Oxidative stress appears to play central role this process. In study, we aimed validate an insect-based model for the investigation oxidative during poisoning lobster cockroach Nauphoeta cinerea. advantages using insects basic toxicological studies include easier handling, rapid proliferation/growing absence ethical issues, comparing...
Abstract Exposure to methylmercury (MeHg), an important environmental toxicant, may lead serious health risks, damaging various organs and predominantly affecting the brain function. The toxicity of MeHg can be related inhibition selenoenzymes, such as glutathione peroxidase (GPx) thioredoxin reductase (TrxR). Experimental studies have shown that selenocompounds play role cellular detoxifiers protective agents against harmful effects mercury. present study investigated mechanisms by which...
The medicinal use of<italic>Euphorbia tirucalli</italic>has to be made with caution, as our study indicates that the aqueous extract induces genotoxicity and cytotoxicity in human leukocytes
Organoselenium compounds have been pointed out as therapeutic agents. In contrast, the potential aspects of tellurides not yet demonstrated. The present study evaluated comparative toxicological effects diphenyl diselenide (PhSe)2 and ditelluride (PhTe)2 in mice after vivo administration. Genotoxicity (as determined by comet assay) mutagenicicity were used end-points toxicity. Subcutaneous administration high doses or (500 µmol/kg) caused distinct genotoxicity mice. significantly decreased...
We evaluated the potential neuroprotective effect of 1-100 µM four organoselenium compounds: diphenyl diselenide, 3’3-ditri-fluoromethyldiphenyl p-methoxy-diphenyl and p-chloro-diphenyl against methylmercury-induced mitochondrial dysfunction oxidative stress in mitochondrial-enriched fractions from adult Swiss mouse brain. Methylmercury (10-100 µM) significantly decreased activity, assessed by MTT reduction assay, a dose-dependent manner, which occurred parallel with increased glutathione...
This study was designed to develop a rodent model of hydrochlorothiazide (HCTZ) toxicity by associating its intake with high-fat (HF) diet. Rats were fed for 16 weeks control diet or an HF supplemented not different doses HCTZ. HCTZ, in similar way the diet, caused significant increase fructosamine levels. HCTZ and reduction magnesium potassium levels, as well lipid peroxidation vitamin C liver. Importantly, negative correlations found between glucose levels The association additional...
Selenium (Se) containing organic compounds, such as ebselen (Ebs) and diphenyl diselenide [(PhSe)2], have been used pharmacological agents due to their antioxidant properties. Tellurium (Te) does not any biological function in mammals, but Te-containing ditelluride [(PhTe)2], has both an or neurotoxic agent. At high concentrations, these compounds cause toxicity by oxidising thiol selenol groups of proteins. Here, we analysed whether could modulate reactive species (RS) production, apoptosis...
The organic tellurium compound (S)-dimethyl 2-(3-(phenyltellanyl) propanamide) succinate (TeAsp) exhibits thiol-peroxidase activity that could potentially offer protection against oxidative stress. However, data from the literature show is a toxic agent to rodents. In order mitigate such toxicity, N-acetylcysteine (NAC) was administered in parallel with TeAsp during 10 days. Mice were separated into four groups receiving daily injections of (A) vehicle (PBS 2.5 ml/kg, i.p. and DMSO 1 s.c.),...
Diphenyl ditelluride (PhTe)₂ is a versatile molecule used in the organic synthesis and it potential prototype for development of novel biologically active molecules. The mechanism(s) involved toxicity is(are) elusive, but thiol oxidation critical proteins are important targets. Consequently, possible remedy its by thiol-containing compounds experimental clinical interest. present study aimed to investigate putative mechanisms underlying vivo. We assessed behavioral oxidative stress...
Compreender a ciência e sua relevância no cotidiano é essencial para que cidadãos possam debater questões sociais, ambientais de saúde pública. Neste contexto, divulgação científica uma forma popularização da ciência, permitindo sociedade tenha acesso diversidade conhecimentos. Assim, o presente trabalho teve como objetivo avaliar estudantes do Ensino Médio interior Mato Grosso Sul percebem divulgação. O estudo foi realizado por meio pesquisa descritiva quali-quantitativa, com um...