A5016163837- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Selenium in Biological Systems
- Enzyme Catalysis and Immobilization
- Microplastics and Plastic Pollution
- Redox biology and oxidative stress
- biodegradable polymer synthesis and properties
- Surfactants and Colloidal Systems
- Sulfur Compounds in Biology
- Environmental Toxicology and Ecotoxicology
- Heavy metals in environment
- Air Quality and Health Impacts
- Nanoparticles: synthesis and applications
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Analytical Chemistry and Chromatography
- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Advanced Polymer Synthesis and Characterization
- Glutathione Transferases and Polymorphisms
- Graphene and Nanomaterials Applications
- Chromium effects and bioremediation
- Recycling and Waste Management Techniques
Université Claude Bernard Lyon 1
2025
institut Camille-Jordan
2025
Centre National de la Recherche Scientifique
2025
University of Lisbon
2014-2024
Centro Hospitalar Lisboa Norte
2021
Karolinska Institutet
2008-2012
Nobel Foundation
2008
Instituto Superior Técnico
1997-2003
Instituto de Biologia Experimental e Tecnológica
2000-2003
Instituto Politécnico de Lisboa
1997-1999
Microplastics pollution is a global paradigm that raises concern in relation to environmental and human health. This study investigated toxic effects of microplastics mercury the European seabass (Dicentrarchus labrax), marine fish widely used as food for humans. A short-term (96 h) laboratory bioassay was done by exposing juvenile (0.26 0.69 mg/L), (0.010 0.016 mg/L) binary mixtures two substances using same concentrations, through test media. alone caused neurotoxicity acetylcholinesterase...
Mercury toxicity mediated by different forms of mercury is a major health problem; however, the molecular mechanisms underlying remain elusive. We analyzed effects mercuric chloride (HgCl(2)) and monomethylmercury (MeHg) on proteins mammalian thioredoxin system, reductase (TrxR) (Trx), glutaredoxin glutathione (GR) (Grx). HgCl(2) MeHg inhibited recombinant rat TrxR with IC(50) values 7.2 19.7 nm, respectively. Fully reduced human Trx1 bound lost all five free thiols activity after incubation...
The presence of microplastics and several other pollutants in the marine environment is growing concern. However, knowledge on toxicity mixtures containing contaminants to species still scarce. main goals this study were investigate oxidative stress lipid damage potentially induced by 96 h exposure mercury (0.010 0.016 mg/L), (0.26 0.69 two substances (same concentrations, full factorial) gills liver D. labrax juveniles, possible influence bioconcentration (gills) bioaccumulation (liver)....
The main objectives of this study were to investigate the effects a mixture microplastics and mercury on Corbicula fluminea, post-exposure recovery, potential influence bioconcentration by species. Bivalves collected in field acclimated laboratory conditions for 14 days. Then, 14-day bioassay was carried out. exposed 8 days clean medium (control), (0.13 mg/L), (30 µg/L) (same concentrations) both substances. recovery investigated through 6 additional medium. After days, following endpoints...
Mercury toxicity is a highly interesting topic in biomedicine due to the severe endpoints and treatment limitations. Selenite serves as an antagonist of mercury toxicity' but molecular mechanism detoxification not clear. Inhibition selenoen-zyme thioredoxin reductase (TrxR) suggested toxicity. Here, we demonstrated enhanced inhibition activity by inorganic organic compounds NADPH-reduced TrxR, consistent with binding also active site selenolthiol. On 5 µM selenite NADPH' TrxR inactivated...
Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides proteins. Thus, the components of two major cellular antioxidant systems – glutathione (GSH) thioredoxin (Trx) are likely targets for mercurials. Hg exposure results GSH depletion Trx reductase (TrxR) prime mercury. These have a wide-range common functions interaction between their has been reported. However, toxic effects over normally treated as isolated events. To study how is affected by Hg,...
We numerically study Turing patterns (TPs) on two-dimensional surfaces with a square boundary in R3 using surface model for polymerized membranes. The variables used to describe the membranes correspond two distinct degrees of freedom: an internal degree freedom polymer directions addition positional freedom. This generalised enables us identify non-trivial interference between TP system and To this end, we employ hybrid numerical technique, utilising Monte Carlo updates membrane...
Abstract Exposure to methylmercury (MeHg), an important environmental toxicant, may lead serious health risks, damaging various organs and predominantly affecting the brain function. The toxicity of MeHg can be related inhibition selenoenzymes, such as glutathione peroxidase (GPx) thioredoxin reductase (TrxR). Experimental studies have shown that selenocompounds play role cellular detoxifiers protective agents against harmful effects mercury. present study investigated mechanisms by which...
Glioblastoma multiforme (GBM) is the most common, aggressive, and fatal primary malignant brain tumor in adults. The therapeutic efficacy of temozolomide (TMZ) limited owing to frequent treatment resistance. latter part related overexpression redox systems such as thioredoxin system. This system fundamental for cell survival proliferation, regulating hypoxia inducible factor-1alpha (HIF-1α) activity, turn controlling vascular endothelial growth factor (VEGF), which indispensable...
Exposure to mercury is normally assessed by measuring its accumulation in hair, blood or urine. Currently, the biomarkers of effect that have been proposed for mercurials, such as coproporphyrines oxidative stress markers, are not sensitive enough and lack specificity. Selenium selenoproteins important targets thioredoxin reductase (TrxR) particular was shown be very compounds both vitro vivo. In this study we looked into relation between inhibition activity histopathological changes caused...
Abstract Methylmercury (MeHg) contamination is a critical public health problem in Portugal, where fish an important component of the daily diet. The Portuguese are third largest consumers world (after Japan and Iceland) but first Europe. Prenatal exposure to MeHg believed be linked fetal/child neurodevelopment behavioral impairments due neurotoxicity compound. objective this study was assess pregnant women mercury (Hg) consumption, calculating indices risk confirming through analyses...