A5002000865- Natural Antidiabetic Agents Studies
- Ginger and Zingiberaceae research
- Phytochemicals and Antioxidant Activities
- Curcumin's Biomedical Applications
- Heavy Metal Exposure and Toxicity
- Cholinesterase and Neurodegenerative Diseases
- Medicinal Plants and Neuroprotection
- Moringa oleifera research and applications
- Pharmacological Effects of Natural Compounds
- Chemotherapy-induced organ toxicity mitigation
- Antioxidant Activity and Oxidative Stress
- Essential Oils and Antimicrobial Activity
- Cholesterol and Lipid Metabolism
- Pharmacological Effects of Medicinal Plants
- Piperaceae Chemical and Biological Studies
- Nigella sativa pharmacological applications
- Ethnobotanical and Medicinal Plants Studies
- Garlic and Onion Studies
- Phytochemistry and Biological Activities
- Cassava research and cyanide
- Sesame and Sesamin Research
- Coenzyme Q10 studies and effects
- Papaya Research and Applications
- Plant Toxicity and Pharmacological Properties
- Mangiferin and Mango Extracts
Albert Einstein College of Medicine
2018-2024
Afe Babalola University
2012-2022
Federal University of Technology
2010-2017
Universidade Federal de Santa Maria
2015-2017
Abubakar Tafawa Balewa University
2014
Abstract Background: Chlorogenic acid is a major phenolic compound that forms substantial part of plant foods and an ester caffeic quinic acid. However, the effect structures both chlorogenic acids on their antioxidant antidiabetic potentials have not been fully understood. Thus, this study sought to investigate compare interaction with α-amylase α-glucosidase (key enzymes linked type 2 diabetes) activities in vitro. Methods: The inhibitory was evaluated. Thereafter, as typified by...
In this study, the effect of enzymes involved in degradation renal adenosine and l-arginine was investigated rats exposed to cadmium (Cd) treated with curcumin, principal active phytochemical turmeric rhizome. Animals were divided into six groups (n = 6): saline/vehicle, saline/curcumin 12.5 mg/kg, 25 Cd/vehicle, Cd/curcumin mg/kg. The results study revealed that activities deaminase arginase significantly increased Cd-treated when compared control (p < 0.05). However, co-treatment curcumin...
Lead (Pb) is an environmental neurotoxicant, and has been implicated in several neurological disorders of dopaminergic dysfunction; however, the molecular mechanism its toxicity yet to be fully understood. This study investigated effect Pb exposure on neurodegeneration function, as well expression level signaling genes wild type (N2) protein kinase C (pkc) mutant Caenorhabditis elegans. Both N2 pkc worms were exposed Pb2+ for 1 h. Thereafter, (DAergic) neurodegeneration, behavior gene levels...
Ginger [Zingiber officinale Roscoe (Zingiberaceae)] and turmeric [Curcuma longa Linn rhizomes have been reportedly used in folk medicine for the treatment of hypertension. However, prevention its complication such as male infertility remains unexplored. Hence, aim present study was to investigate preventive effects ginger on some biomarkers reproductive function L-NAME-induced hypertensive rats. Male Wistar rats were divided into seven groups (n = 10): normotensive control rats; induced...
Cisplatin ( cis -diamminedichloroplatinum (II) or CDDP), used in the treatment of many solid-tissue cancers, has its chief side-effect nephrotoxicity. Hence, this study sought to investigate and compare protective effect gallic acid (GA) tannic (TA) against cisplatin induced nephrotoxicity rats. The rats were given a prophylactic GA TA orally at dose 20 40 mg/kg body weight for 7 consecutive days before administration single intraperitoneal (i.p.) injection (CP) 7.5 bwt. effects both on CP...
Persea americana fruit and leaves had been known in folk medicine for their anti-diabetic prowess. Therefore, this study sought to investigate the inhibitory effect of phenolic extract from avocado pear (Persea americana) fruits on some key enzymes linked type 2 diabetes (α-amylase α-glucosidase); sodium nitroprusside (SNP) induced lipid peroxidation rats' pancreas vitro. The extracts were extracted using methanol 1M HCl (1:1 v/v). Thereafter, effects α-glucosidase) determined result...
Ginger has reportedly been used in folk medicine for the management and prevention of hypertension other cardiovascular diseases. Therefore, this study sought to investigate inhibitory effect aqueous extracts two varieties ginger on a key enzyme linked (angiotensin I–converting [ACE]), pro-oxidants [Fe2+ sodium nitroprusside (SNP)] which have shown induce lipid peroxidation rat's isolated heart vitro. Aqueous (0.05 mg/mL) red (Zingiber officinale var. Rubra) white Roscoe) were prepared...
Angiotensin-1-converting enzyme (ACE) inhibitors are widely used in the treatment of cardiovascular diseases. This study sought to investigate inhibitory effect two varieties ginger (Zingiber officinale) commonly consumed Nigeria on ACE activity rats fed a high cholesterol diet. The inhibition (Z. was investigated (2%) diet for 3 days. Feeding diets caused significant (P<.05) increase activity. However, there as result supplementation with varieties. Rats that were 4% white had greatest...
The phenolic extract of Senecio biafrae leaves was investigated to determine the in vitro antioxidant, profiles, and inhibition key enzymes relevant type II diabetes mellitus (α-amylase α-glucosidase) Alzheimer's disease (acetylcholinesterase butrylcholinesterase). demonstrated significant scavenging abilities against all antioxidant parameters assessed. Reversed-phase HPLC revealed presence gallic acid, chlorogenic, caffeic rutin, quercetin, kaempferol. also inhibited activities α-amylase...
To investigate the inhibitory effect of Telfairia occidentalis Hook f. (Curcubitaceae) (T. occidentalis) leaf on key enzyme linked to type-2 diabetes (α-amylase and α-glucosidase) as well assess blanching (a commonly practiced food processing technique) vegetable these enzymes. Fresh leaves T. were blanched in hot water for 10 minutes, extracts both fresh vegetables prepared used subsequent analysis. The extract α-amylase α-glucosidase activities some antioxidant parameter was determined...
Hypertension is associated with platelet alterations that could contribute to the development of cardiovascular complications. Several studies have reported antiplatelet aggregation properties ginger (Zingiber officinale) and turmeric (Curcuma longa) limited scientific basis. Hence, this study assessed effect dietary supplementation these rhizomes on ectonucleotidase adenosine deaminase (ADA) activities in Nω-nitro-l-arginine methyl ester hydrochloride (l-NAME) induced hypertensive rats....