A5078399370- Heavy Metal Exposure and Toxicity
- Sperm and Testicular Function
- Natural Compound Pharmacology Studies
- Ginger and Zingiberaceae research
- Selenium in Biological Systems
- Cholinesterase and Neurodegenerative Diseases
- Pesticide Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Zebrafish Biomedical Research Applications
- Carcinogens and Genotoxicity Assessment
- Environmental Toxicology and Ecotoxicology
- Phytoestrogen effects and research
- Insect and Pesticide Research
- Aldose Reductase and Taurine
- Trace Elements in Health
- Reproductive System and Pregnancy
- Nanoparticles: synthesis and applications
- Chemotherapy-induced organ toxicity mitigation
- Prenatal Substance Exposure Effects
- Mycotoxins in Agriculture and Food
- Aluminum toxicity and tolerance in plants and animals
- Neurobiology and Insect Physiology Research
- Glutathione Transferases and Polymorphisms
- Insect Pest Control Strategies
- Per- and polyfluoroalkyl substances research
Universidade Federal de Santa Maria
2015-2025
University of Ibadan
2015-2024
Universidade Federal do Rio Grande do Sul
2015-2016
Pondicherry University
2013
Auburn University
2013
The present study was carried out to evaluate the ameliorative effects of kolaviron (a biflavonoid from seeds Garcinia kola) and curcumin (from rhizome, Curcuma longa L.) on di-n-butylphthalate (DBP)-induced testicular damage in rats. Administration DBP rats at a dose 2 g/kg for 9 days significantly decreased relative weights compared controls, while other organs remained unaffected. Curcumin or did not affect all organ animals. While only treatment increased malondialdehyde level...
Abstract The beneficial effects of k olaviron, a natural biflavonoid from the seeds G arcinia kola, have been attributed mainly to its antioxidant and anti‐inflammatory effects. This study investigated these on dextran sulphate sodium ( DSS )‐induced ulcerative colitis in rats. Sulfasalazine served as standard reference this study. Kolaviron sulfasalazine were separately co‐administered orally at 200 mg/kg 500 mg/kg, respectively, sodium‐exposed rats for 5 days. result indicated that...
This study evaluated the effects of kolaviron, a biflavonoid from Garcinia kola seed, and quercetin on cadmium-induced reproductive toxicity in rats. Adult male rats were administered with either cadmium (15 mg kg−1) alone or combination kolaviron (200 (10 daily for 5 days. Cadmium-treated showed (P < 0.05) decrease body weight gain, testis epididymis weights. However, upon co-administration quercetin, these changes significantly reversed cadmium-treated Also, administration prevented...
The present study investigated the antioxidant and anti-inflammatory effects of dietary protocatechuic acid (PCA), a simple hydrophilic phenolic compound commonly found in many edible vegetables, on dextran sulphate sodium (DSS)-induced ulcerative colitis its associated hepatotoxicity rats. PCA was administered orally at 10 mg kg(-1) to exposed rats for five days. result revealed that administration significantly (p < 0.05) prevented incidence diarrhea bleeding, decrease body weight gain,...
Gingerols are phenolic compounds in ginger ( Zingiber officinale ), which have been reported to exhibit antiinflammatory, antioxidant, and anticancer properties. The present study aimed at evaluating the possible pharmacologic activity of 6‐gingerol a mouse model dextran sulphate sodium (DSS)‐induced ulcerative colitis. Adult male mice were exposed DSS drinking water alone or co‐treated with orally 50, 100, 200 mg/kg for 7 days. Disease index, inflammatory mediators, oxidative stress...
The protective role of gallic acid (GA) on reproductive toxicity induced by cyclophosphamide (CPA), an antineoplastic drug, was investigated in male Wistar rats. Sixty rats were grouped into 10 per group. Group 1 (control) received distilled water. Rats groups 2 and 3 GA alone at 60 120 mg kg(-1) for 14 consecutive days, respectively. 4 a single intraperitoneal dose CPA 200 day 1. Groups 5 6 (200 ) intraperitoneally followed treatment with In testes epididymis the treated rats,...
Ginger [Zingiber officinale Roscoe (Zingiberaceae)] and turmeric [Curcuma longa Linn rhizomes have been reportedly used in folk medicine for the treatment of hypertension. However, prevention its complication such as male infertility remains unexplored. Hence, aim present study was to investigate preventive effects ginger on some biomarkers reproductive function L-NAME-induced hypertensive rats. Male Wistar rats were divided into seven groups (n = 10): normotensive control rats; induced...
Infertility resulting from reproductive deficiency can be stressful. Exposure to aflatoxin B1, a dietary mycotoxin prevalent in improperly stored grains, is reported elicit insufficiencies and infertility. We, therefore, examined the likely beneficial effect of gallic acid (GA) phytochemical, recognized exhibit vitro vivo pharmacological bioactivities against oxidative stress related inflammatory damages rats, since AFB1 toxicities are predicated on epoxide formation, bid proffer new...
Abstract Olive oil production yields a substantial volume of by‐products, constituting up to 80% the processed fruits. The olive pomace by‐product represents residue significant interest due diverse bioactive compounds identified in it. However, thorough characterization and elucidation biological activities are imperative redirect its application for functional food, nutraceutical, pharmaceutical purposes both animals humans. In this review, we examine data from experimental models,...
Abstract The local population of Niger‐Delta in the Southern part Nigeria have used bonny light crude oil (BLCO) as a remedy for various ailments and are exposed to some extent this widespread environmental contaminant or its metabolites through food chain. BLCO's hepatorenal toxicity was studied using oxidative stress indices elucidate precise nature mechanism action. BLCO orally administered at concentrations 0, 200, 400, 800 mg kg −1 adult male rats 7 days. After exposure, kidney weight...
Methylmercury (MeHg) is well-known for its neurodevelopmental effects both in animals and humans.
Context: In Africa, Garcinia kola Heckel (Guttiferae) seed is commonly recommended in folklore medicine for the treatment of diabetes and its associated complications.Objective: The present study evaluated this traditional claim by mechanistic investigation into effect G. administration on renal, hepatic, testicular oxidative damage streptozotocin (STZ)-induced diabetic rats.Materials methods: Diabetes mellitus was induced adult male Wistar rats an intraperitoneal injection STZ (50 mg/kg)....