A5012033153- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Vitamin C and Antioxidants Research
- Chemotherapy-induced organ toxicity mitigation
- Natural Antidiabetic Agents Studies
- Drug-Induced Hepatotoxicity and Protection
- Medicinal Plants and Neuroprotection
- Moringa oleifera research and applications
- Arsenic contamination and mitigation
- Immunotoxicology and immune responses
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Medicinal Plants
- Ethnobotanical and Medicinal Plants Studies
- Mycotoxins in Agriculture and Food
- Animal health and immunology
- Essential Oils and Antimicrobial Activity
- Carcinogens and Genotoxicity Assessment
- Therapeutic Uses of Natural Elements
- Nigella sativa pharmacological applications
- Aldose Reductase and Taurine
- Pharmacological Effects of Medicinal Plants
- Sodium Intake and Health
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
University of Ibadan
2014-2024
University of Fort Hare
2018
ABSTRACT Removal of lead from the environment man or otherwise, movement lead‐contaminated areas has been employed as a means abatement toxic effects lead. Whether in already‐exposed individuals subside after withdrawal remains unanswered. To understand reversibility nephrotoxicity induced by acetate, male Wistar rats were orally exposed to 0.25, 0.5, and 1.0 mg/mL acetate for 6 weeks. Activities glutathione‐s‐transferase, catalase (CAT), superoxide dismutase (SOD) concentrations hydrogen...
This study evaluated the effects of kolaviron, a biflavonoid from Garcinia kola seed, and quercetin on cadmium-induced reproductive toxicity in rats. Adult male rats were administered with either cadmium (15 mg kg−1) alone or combination kolaviron (200 (10 daily for 5 days. Cadmium-treated showed (P < 0.05) decrease body weight gain, testis epididymis weights. However, upon co-administration quercetin, these changes significantly reversed cadmium-treated Also, administration prevented...
The protective role of gallic acid (GA) on reproductive toxicity induced by cyclophosphamide (CPA), an antineoplastic drug, was investigated in male Wistar rats. Sixty rats were grouped into 10 per group. Group 1 (control) received distilled water. Rats groups 2 and 3 GA alone at 60 120 mg kg(-1) for 14 consecutive days, respectively. 4 a single intraperitoneal dose CPA 200 day 1. Groups 5 6 (200 ) intraperitoneally followed treatment with In testes epididymis the treated rats,...
Cyclophosphamide (CPA) is a widely used anticancer chemotherapeutic agent and its toxicity has been associated with toxic metabolites phosphormide mustard. Therefore, the ameliorative effect of Gallic acid against neurotoxicity was examined in this study. Sixty rats were grouped into 10 per group. Group 1 received saline orally. 2 CPA at 100 mg/kg single dose intraperitoneally on day 1. Groups 3 4 treated (GA) 60 120 body weight only for days also (100 mg/kg) 1, respectively. Rats groups 5 6...
Background: Moringa oleifera is known to exhibit protection against oxidative damage due its rich content of compounds with antioxidant activity. This study investigated the protective effect methanol extract (MO) in a rat model renal ischemia-reperfusion (IR) injury.
 Methods: Forty two wistar rats were randomly assigned six groups seven each, as follows: A, control group; B, sham-operated C, IR D, + low dose (200 mg/kg) MO; E, high (400 MO and F, Vitamin C mg/kg). Unilateral ischaemia...
Pharmacognosy Research,2016,8,5,26-30.DOI:10.4103/0974-8490.178645Published:March 2016Type:Original ArticleAuthors:Olufunke Eunice Ola‑Davies, and Akinleye Stephen Akinrinde Author(s) affiliations:Olufunke Ola-Davies, Department of Veterinary Physiology, Biochemistry Pharmacology, Faculty Medicine, University Ibadan, Oyo State, NIGERIA. Abstract:Background: Ageratum conyzoides L. (Asteraceae) is an annual herbaceous plant used in folklore medicine for the treatment a wide range diseases....
Parquetina nigrescens is a medicinal herb with recognized antioxidant properties and potential to alleviate conditions associated oxidative stress, including gastric ulcers. We investigated the protective of methanol extract (MEPN) against ischemia-reperfusion injury in intestine rats. Thirty (30) male Wistar albino rats were randomly assigned into five groups Group I made up control II consisting experimentally subjected ischemia reperfusion (IR) by clamping superior mesenteric artery (SMA)...
The corms of Hypoxis argentea are widely used as a traditional remedy for diabetes mellitus in South Africa. In this study, we investigated the effects non-toxic concentrations (12.5-100 μg mL-1) aqueous extract H. (HAA) on glucose uptake, pancreatic beta cell proliferation, and adipocyte differentiation. HAA stimulated uptake HepG2 cells up to 19.6 % 17.0 L6 myotubes. Live-cell imaging microscopy revealed significant increases (p < 0.001) total INS-1 numbers exposed HAA, although no effect...
Cobalt (Co) toxicity is a potential public health problem due to recent renewed use of Co in orthopedic implants, dietary supplements, and blood doping athletes horses. We investigated the protective roles kolaviron (KV), bi-flavonoid Garcinia kola, gallic acid (GA) on cobalt chloride (CoCl2)-induced cardiorenal damage rats. CoCl2 caused significant increases (p < 0.05) serum creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH), aspartate transaminase (AST), xanthine oxidase...
This study examined the protective effects of Nigella sativa oil (NSO) on cadmium (Cd)-induced alterations affecting gut morphology and microbiota composition, as well involvement mucus glycoprotein (MUC2) immuno-inflammatory markers (TNFα IL-2) in colon rats.Male Wistar rats, randomized into four groups, were treated either with distilled water (control), CdCl2 (100 mg/kg), CdCl2+NSO (1 ml/kg) or NSO alone. After experiments, faecal samples processed for microbial culture various selective...
Inhabitants of the Eastern Cape Province South Africa use roots Dianthus thunbergii and corms Hypoxis argentea to treat diabetes mellitus other ailments.The objective this study was analyze phytochemical composition antioxidant activities aqueous ethanol extracts two plants.Total phenolics, flavonoids, flavonols, proanthocyanidins, tannins, alkaloids were determined by standard methods. The scavenging against 1,1 diphenyl-2-picrylhydrazyl (DPPH), 2'-azino-bis (3-ethylbenthiazoline-6-sulfonic...
Arsenic intoxication is known to produce symptoms including diarrhea and vomiting, which are indications of gastrointestinal dysfunction.We investigated whether Kolaviron (KV) administration protected against sodium arsenite (NaAsO2)-induced damage gastric intestinal epithelium in rats.Control rats (Group I) were given a daily oral dose corn oil. Rats other groups single NaAsO2 (100 mg/kg; intraperitoneal) alone II) or after pretreatment for 7 days with KV at 100 mg/kg III) 200 IV)....
NSAID-induced gastrointestinal toxicity is associated with non-selective inhibition of cyclooxygenase (COX)-mediated synthesis prostaglandins. Fluoride salts, known to stimulate COX-2 synthesis, have also been damage. The effects fluoride treatment on NSAID are, however, yet be clarified. This study examined the effect sodium (NaF) diclofenac (DIC)-induced gastroduodenal and hepatic in rats. In addition, potential protective role Luteolin (Lut), an antioxidant anti-inflammatory flavonoid,...
Abstract Background Eucalyptus oil (EO), derived from species, possesses vast remedial and healing properties, although its gut health-promoting properties have not been well investigated. In this study, we investigated the chemical composition of a commercial EO formulation potential role in protecting against aflatoxin B1 (AfB1)-induced gastrointestinal damage rats. Methods Male Wistar rats were divided into six groups with eight each. Control administered vehicle (1% Tween 80) for 14...
Sesame oil, an edible essential is known to be rich in unsaturated fatty acids, vitamins and lignans with several reported health-promoting benefits. Acute arsenic poisoning produces toxic hepatitis, bone marrow depression adverse gastrointestinal responses. In this study, we investigated the protective effect of sesame seed oil (SSO) against genotoxicity, hepatotoxicity colonic toxicity induced by sodium arsenite (SA) Wistar rats.Twenty-eight male albino rats were randomly allocated into...