A5043078523- Natural Antidiabetic Agents Studies
- Ethnobotanical and Medicinal Plants Studies
- Moringa oleifera research and applications
- Sodium Intake and Health
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Vitamin C and Antioxidants Research
- Phytochemistry and Bioactivity Studies
- Fluoride Effects and Removal
- Phytochemicals and Antioxidant Activities
- Heavy Metal Exposure and Toxicity
- Phytochemistry and biological activity of medicinal plants
- Apelin-related biomedical research
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Essential Oils and Antimicrobial Activity
- Toxin Mechanisms and Immunotoxins
- Eicosanoids and Hypertension Pharmacology
- Trypanosoma species research and implications
- Andrographolide Research and Applications
- Medicinal Plants and Neuroprotection
- Hibiscus Plant Research Studies
- Natural Compound Pharmacology Studies
- Arsenic contamination and mitigation
University of Ibadan
2016-2025
Michigan Department of Health and Human Services
2024
Texas Southern University
2011-2021
University College Hospital, Ibadan
2003-2021
Pan-Atlantic University
2021
Cape Peninsula University of Technology
2021
Gauteng Department of Agriculture and Rural Development
2020
University of South Africa
2020
University of Ilorin
2019
University of Benin
2018
Caffeic acid (CAA) and chlorogenic (CHA) are important members of hydroxycinnamic with natural antioxidant cardio-protective properties. The present study aimed to determine the effect CAA CHA on systolic blood pressure, heart rates (HR) as well activity angiotensin-1-converting enzyme (ACE), acetylcholinesterase (AChE), butrylcholinesterase (BChE) arginase in cyclosporine-induced hypertensive rats. Experimental rats were distributed into 7 groups (n = 6): normotensive control rats; (induced...
In South Africa, Calpurnia aurea (Ait.) Benth is used to destroy lice and relieve itches, maggots treat allergic rashes, particularly those caused by caterpillars. Antioxidants play an important role protecting against damage reactive oxygen species. Plants containing flavonoids have been reported possess strong antioxidant properties. The antibacterial, activities phenolic contents of the methanol extracts leaves stems were evaluated using in vitro standard methods. Spectrophotometry was...
The aqueous extract from the leaves of Moringa oleifera was evaluated for its oral toxicity by route, and sub-acute on haematological, biochemical histological parameters in rats. In acute test, M. oleifera extract caused no death animals even at 2000 mg/kg dose. Oral treatments rats with this 400, 800 1600 varied significant changes total RBC, packed cell volume (PCV), haemoglobin percentage (HB), mean corpuscular (MCV), concentration (MCHC), differential WBC. did not cause any change level...
ABSTRACT Human exposure to sodium fluoride through its daily usage is almost inevitable. Cardiovascular and renal dysfunction has been associated with toxicity. Therefore, this study investigated the mechanism of action (NaF) induced hypertension cardiovascular complications Forty male albino rats an average 10 per group were used. Group A received clean tap water. Toxicity was in B D by administering graded doses NaF drinking water ad libitum for days at 150 ppm, 300 600 ppm concentration...
Acokanthera oppositifolia Lam (family: Apocynaceae) is a shrub or small tree with white latex, and the leaves of this plant are used in form snuff to treat headaches infusions for abdominal pains convulsions septicaemia. Adenia gummifera Harv family Passifloraceae distinctive woody climber whose as emetics said help some forms depression. Lipid peroxidation has gained more importance today because its involvement pathogenesis many diseases. Free radicals main agents lipid peroxidation....
Buddleja saligna Willd (Loganiaceae) is a small to medium-sized evergreen tree; trunk short, often gnarled and crooked; crown dense, rounded or domed-shaped; foliage greyish green. The wild olives are traditionally used lower blood pressures in many parts of the world. In southern Africa, bark leaf decoctions treat colic, coughs, colds, sore eyes, urinary problems as purgatives.The antibacterial, antioxidant activities phenolic contents methanol extracts leaves stems were evaluated using...
Abstract Background: Moringa oleifera Lam (Moringaceae) is a highly valued plant, distributed in many countries of the tropics and subtropics. It has an impressive range medicinal uses with high nutritional value. Methods: The commercially processed M. was extracted using methanol as its solvent. Phytochemical analysis well anti-oxidant properties this supplement were also investigated. Acute toxicity carried out fasted mice. Carrageenan histamine tests used to assess anti-inflammatory...
Cobalt is a ferromagnetic metal with extensive industrial and biological applications. To assess the toxic effects of, mechanisms involved in cobalt chloride (CoCl2)-induced cardio-renal dysfunctions. Male Wistar rats were exposed orally, daily through drinking water to 0 ppm (control), 150 ppm, 300 600 of CoCl2, respectively. Following exposure, results revealed significant ( p < 0.05) rise markers oxidative stress, but decreased activities catalase, glutathione peroxidase,...
Abstract Hypertension is one of the silent killers in world with high mortality and morbidity. The exposure humans animals to fluoride and/or containing compounds almost inevitable. This study investigated modulatory effects quercetin on sodium (NaF)‐induced hypertension cardiovascular complications. Forty male rats were randomly separated into four groups ( n =10). Group A served as control, B exposed 300 ppm NaF, Groups C D NaF along orally at 50 mg/kg 100 by gavage, while was administered...
Myocardial infarction (MI) is the most prevalent cause of cardiovascular death. A possible way preventing MI maybe by dietary supplements. The present study was thus designed to ascertain cardio-protective effect a formulated curcumin and nisin based poly lactic acid nanoparticle (CurNisNp) on isoproterenol (ISO) induced in guinea pigs. Animals were pretreated for 7 days as follows; Groups B animals given 0.5 mL/kg normal saline, group C metoprolol (2 mg/kg), groups D E CurNisNp 10 21 mg/kg...
The use of sodium fluoride (NaF) as a major ingredient for tooth paste, mouth wash, and rinse has become inevitable in our day-to-day life. However, flavonoids such Luteolin might be great value the prevention toxicity associated with accidental or ingestion NaF. In study, 40 male Wistar albino rats were randomly divided into four groups 10 group. Group A was control group received normal saline, B exposed to NaF at 300 ppm (300 mg/L) drinking water daily week, Groups C D coadministered...
Hepatotoxicity has been found to be one of the main side effects associated with doxorubicin (Dox) administration in cancer therapy. The aim present study was examine ameliorative effect gallic acid (GA) Dox-induced hepatotoxicity. Sixty male Wistar rats 10 per group were used this and randomly divided into 6 experimental groups (A-F). Rats Group A served as control received distilled water orally for 7 days; B given Dox at 15 mg/kg body weight intraperitoneally (IP) on Day 8. C GA 60 days +...
Abstract Background: In developing countries, the rate of complications from chronic suppurative otitis media is still high, due to factors associated with poverty. This study aimed determine prevalence and complications. Patients methods: We prospectively studied all patients presenting ear, nose throat unit Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria, over a two-year period. Results: One hundred sixty new cases were seen. These constituted 11.1 per cent 21.5...
Vernonia amygdalina is a medicinal plant of great importance that has its fresh leaves rich in vitamins and salt hence, it valuable human diet. The anti-oxidant, anti-inflammatory analgesic activities acetone leaf extract were evaluated this study to validate folkloric use.The prepared by dissolving ground materials (200g) 1 L for 48 h, filtered, then dried using rotary evaporator before used the pharmacological investigations. Standard phytochemical methods test presence phytoactive...
Abstract Environmental and occupational exposure to chromium compounds has become potential aetiologic agent for kidney disease with excessive generation of free radicals, apoptosis, inflammatory. These pathophysiologic mechanisms potassium dichromate (K 2 Cr O 7 ) have been well correlated nephrotoxicity cardiotoxicity. The cardioprotective nephroprotective effects Luteolin, a known potent antioxidant were evaluated in this study 40 healthy rats four experimental groups: Group A (normal...