A5033494159- Pesticide Exposure and Toxicity
- Sperm and Testicular Function
- Pesticide and Herbicide Environmental Studies
- Heavy Metal Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Reproductive Biology and Fertility
- Trace Elements in Health
- Paraquat toxicity studies and treatments
- Advances in Cucurbitaceae Research
- Selenium in Biological Systems
- Biological Activity of Diterpenoids and Biflavonoids
- Moringa oleifera research and applications
- Drug-Induced Hepatotoxicity and Protection
- Genomics, phytochemicals, and oxidative stress
- Chemotherapy-induced organ toxicity mitigation
- COVID-19 Clinical Research Studies
- Heavy metals in environment
- Plant Toxicity and Pharmacological Properties
- Curcumin's Biomedical Applications
- Environmental Toxicology and Ecotoxicology
- Natural Compound Pharmacology Studies
- Vitamin C and Antioxidants Research
- Mercury impact and mitigation studies
- Chromosomal and Genetic Variations
- Traditional and Medicinal Uses of Annonaceae
University of Port Harcourt
2015-2024
Universal Scientific Education and Research Network
2024
University of Technology and Applied Sciences-Suhar
2022
Association for Behavior Analysis International
2020
Redeemer's University
2008-2014
University of Ibadan
2006-2012
Cyclophosphamide (CYC) as an anticancer alkylating agent has been known a male reproductive toxicant. This study was aimed to evaluate the protective effect of rutin (RUT) on CYC-induced toxicity. Sexually mature Wistar rats (weighing 199 ± 10 g with five animals in each group) were given CYC (15 mg/kg) and/or RUT (30 twice week via gavage for 4 weeks. The sperm counts, motility, morphology, daily production (DSP), testicular, and epididymal antioxidant systems: superoxide dismutase (SOD),...
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the 'Save PDF' action button.
The present study was carried out to evaluate the ameliorative effects of kolaviron (a biflavonoid from seeds Garcinia kola) and curcumin (from rhizome, Curcuma longa L.) on di-n-butylphthalate (DBP)-induced testicular damage in rats. Administration DBP rats at a dose 2 g/kg for 9 days significantly decreased relative weights compared controls, while other organs remained unaffected. Curcumin or did not affect all organ animals. While only treatment increased malondialdehyde level...
Background: The potential toxicity resulting from the possible interactions of herbicides, Ultrazin (atrazine, ATZ) and Bretmont Wipeout (glyphosate, GLY) (as commercialized in Nigeria), is not completely known. We therefore evaluated reproductive- hepato-toxicity rats co-exposed to ATZ GLY.Methods: Six weeks old male were exposed by gavage three times per week (12.5 mg/kg) or GLY (5 alone combination mg/kg + 5 vehicle (corn oil), for 52 days.Results: impaired sperm quality but has more...
Exposure to cadmium (Cd) reduces sperm quality and induces oxidative stress in the testis. Rutin is an effective antioxidant flavonoid. We studied effect of ethanol (EtOH, 5 g/kg b.wt.) intake on Cd (50 mg/kg b.wt.)-induced testicular toxicity with or without RUT pre-treatment (25, 50, 100 rats. At end 15-day oral treatment, co-treatment EtOH decreased activities glutathione (GSH), GSH-peroxidase superoxide dismutase resulting slight increase MDA level compared Cd-treated The Cd+EtOH animals...
The conflicting roles of quercetin against tissue pathologies associated with oxidative stress are known.
Cadmium (Cd) is known to cause oxidative damage in the testes of rats. The aim this study was investigate protective role rutin (RUT, 30 mg/kg) and selenium (Se, 0.15 ppm) alone or combination against Cd (200 ppm)-induced lipid peroxidation, steroidogenesis changes antioxidant defence system rat testes. obtained results showed that increased peroxidation abnormal sperm count decreased plasma testosterone, lactate dehydrogenase, acid phosphatase, alkaline phosphatase testicular steroidogenic...
In the present study, aqueous leaf extract of Annona muricata was assessed for its capacity to mitigate testicular damages and sperm toxicity induced by gasoline fumes. Thirty‐two male Wistar rats were randomized into four groups eight animals per group: control group given distilled water, PEBI exposed petrol inhalation petrol‐exposed that concomitantly treated with A. at 100 200 mg kg −1 body weight (b.w), respectively (PEBI + AM100 AM200) via oral gavage. Oxidative stress markers, quality...
Kolaviron (KV), a natural biflavonoid obtained from the seeds of Garcinia kola, has been documented for its wide pharmacological window, including anti-apoptotic activities. However, underlying mechanisms are poorly understood at cellular level. This study investigates activity KV in PC12 cells, rat pheochromocytoma, exposed to endocrine disruptor-atrazine (ATZ). (60 μM) treatment 24 h shows significant responses cells ATZ (232 h. recovers ATZ-induced levels malondialdehyde, reactive oxygen...
ABSTRACT Quercetin ( QT ), a dietary‐derived flavonoid, is ubiquitous in fruits and vegetables plays an important role human health by virtue of its antioxidant function. The present study was designed to examine the effects on oxidative damage that induced herbicide, atrazine ATZ mixed cultures Sertoli‐germ cells. Results showed treatment with increased cell viability decreased catalase activity, malondialdehyde, reactive oxygen species ROS ) levels. also m RNA expression glutathione...
Abstract: Excessive and sustained increases in oxidative stress apoptosis have been implicated the pathogenesis of many diseases. In this study, we demonstrated that 4‐hydroxynonenal (4‐HNE), a product lipid peroxidation range concentration (0.1–50 μM) showed cytotoxic effects on SH‐SY5Y cell culture at >5 μM 4 hr exposure. 4‐HNE dose dependently decreased viability significantly promoted reactive oxygen species formation enhanced as reflected increased level catalase activity glutathione...
The protective effect of quercetin (QT) on atrazine (ATZ)-induced testicular damage in rats was investigated. Sexually mature male Wistar (weighing 220-250 g) divided into four groups with six animals each group were given ATZ (120 mg kg(-1); 1/16 the median lethal dose for an oral dose) and/or QT (10 kg(-1)) daily via gavage 16 days. By end day 16, alone had significantly lower sperm counts, spermatozoa production, and motility higher abnormal numbers than untreated control rats. also...
Rutin (RUT) is an antioxidant flavonoid with well-known metal chelating potentials.This study was designed to evaluate the protective effects of RUT against cadmium (Cd) + ethanol (EtOH)-induced hepatic and renal toxicity in rats.Wistar rats were treated Cd (50 mg/kg) alone or combination EtOH (5 (25, 50 100 for 15 days. After treatment, liver, kidney serum removed biochemical assays by spectrophotometric methods.Serum, malondialdehyde (MDA) levels highest group lowest animals co-treated...