In the present study, aqueous leaf extract of Annona muricata was assessed for its capacity to mitigate testicular damages and sperm toxicity induced by gasoline fumes. Thirty‐two male Wistar rats were randomized into four groups eight animals per group: control group given distilled water, PEBI exposed petrol inhalation petrol‐exposed that concomitantly treated with A. at 100 200 mg kg −1 body weight (b.w), respectively (PEBI + AM100 AM200) via oral gavage. Oxidative stress markers, quality...

The present study evaluated the protective effect of ascorbic acid (ASCB) against gasoline fumes (PET) induced testicular oxidative stress, sperm toxicity, and testosterone imbalance in Wistar rats. Twenty-four (24) male albino rats (75 ± 16 g) were randomized into three experimental groups ( N = 8). control group: received normal saline, PET exposed to 6 h daily by inhalation an exposure chamber + 200 mg ASCB/kg body weight administered ASCB per os. Treatment was done thrice five times...

Triazines are environmental active chemicals that have been reported to alter the inflammatory status of gonads. We tested anti-inflammatory effect triazines (atrazine; ATZ, simazine; SMZ and cyanazine; CYZ) on testis compared it with more classical liver model has substantial populations resident macrophages comparable testis.

Cadmium (Cd) is a toxic metal that damages several tissues of animals and humans including the testis. The ameliorative effects quercetin (QUE), rutin (RUT), gallic acid (GAL) at 20 mg kg-1 body weight alone or in combination against testicular injury induced by Cd (24 weight) male Wistar rats were evaluated this study. Forty-two (42) randomly grouped into six (6) groups: (1) vehicle control group, (2) (3) RUT+Cd (4) GAL+Cd (5) QUE+Cd RUT+GAL+QUE+Cd group. At end oral gavage tested...

Several anticancer drugs are coadministered with ascorbate (ASCB) to complement their cytotoxic effects. However, it is not known if the treatment regimen prevents collateral oxidative damage non-target sites. The current study evaluated effect of ASCB cotreatment on testes young adult rats treated an drug, busulfan (BUS). About 40 Wistar were arbitrarily assigned into four groups (N = 10), namely, control (<0.2% dimethyl sulfoxide vehicle), BUS (4 mg/kg b.w.; intraperitoneally for 4...

Aim: The ability of ethylacetate extract Persea americana Mill (avocado) seed to ameliorate the hepatotoxic effect acetaminophen in rats was assessed. Methodology: Thirty experimental were placed 6 groups 5 animals per group. Two animal received distilled water and drug vehicle, dimethyl sulphoxide (DMSO). Four other (750 mg/kg bw/day) DMSO for 3 days with 4 receiving, after administration 11 days, extracts (150-, 350 bw) silymarin (200 bw). Animals sacrificed both serum liver tissue...

The effect of aqueous extract Irvingia wombolu seeds on lipid profile and atherogenic indices in hyperlipidemic wistar rats was evaluated. Forty five (45) were grouped into groups nine each. animals allowed seven days acclimatization period. Group one the control group it received normal rat chow water throughout study. Groups 2 to 5 given high fat diet for 14 after which they fed with till end At days, not treated while 3-5 250, 500 1000mg/kg body weight seed respectively 28 days. assayed...

The present study was designed to evaluate the protective effect of fluted pumpkin seeds (FPS) against caffeine (CAFF) induced testicular toxicity in rats. Thirty young healthy male Wistar rats (196 ± 12 g) were randomly organized into five sets six animals per each group: control, (CAFF; 50 mg kg-1 bw) and FPS co-treatment groups (CAFF + FPS, CAFF 100 200 bw). administered daily twice week respectively by oral gavage for 40 days. treatment decreased lactate dehydrogenase enzyme activity...

This study examined the effects of cadmium (Cd) on testes rats and efficacy fluted pumpkin seeds (FPS) supplementation. Twenty-four adult male (150–190 g) were allocated into four groups. I: control; corn oil (2 ml/kg); II: Cd (24 mg/kg); III: mg/kg) + FPS (25 IV: (250 mg/kg). After 44 days, killed serum isolated for experimental analysis. treatment significantly increased concentrations malondialdehyde, nitric oxide, abnormal histological features (Sertoli cells-only tubules, atrophy,...

The effect of fluted pumpkin seeds (FPS) consumption on the antioxidant status testes aged Wistar rats was evaluated in this study. Sixty (50 aged, 6 months old, and 10 young, 2 old) were divided into six groups per each group. Testosterone (15 mg kg-1 body weight, once weekly for 40 days) injected intraperitoneally used as positive control. FPS intake (50, 100, 200 weight) or vehicle control (corn oil) administered orally, twice days compared with untreated young rats. Changes testis...

The proximate, phytochemicals, volatile organic compounds and mineral compositions of Lageneria breviflora seeds were evaluated in this study using standard methods. results showed appreciable amount nutrient. Proximate composition that the seed contains 54.87% carbohydrate, 15.37% fat 3.65% crude protein. Anthocyanin (77.55µg/g) had highest concentration among phytochemicals present. Majority predominantly present flavonoid class. Oxalate, tannin, alkaloid found quantities. following...

This study was conducted to evaluate the effect of topical application dichloromethane extract Heterotis rotundifolia leaves on iron,estrogen levels, haematology parameters and rate wound healing closure. Excision (2cm) induced dorsal skin 75 wistar rats (176-308g) divided into five groups: control, 0.1g Vaseline, gentamicin (reference drug), extract+0.1g Vaseline (HRE1) 0.2g (HRE2). At end days 1, 7, 14 21, were sacrificed blood collected for parameters. The iron level HRE1 significantly...

This study evaluated the effect of ethanol extract Persea americana pulp on caffeine induced testicular damage male wistar rats. Fifty-four (54) mature rats were used, they divided into six (6) groups nine (9) Group 1 was not with caffeine, two(2) to group six(6) 200mg/kg for two weeks. Three sacrificed from each after weeks induction. Semen and testes collected total sperm count, motility, morphology, vitality histopathology. The treated as follows another four weeks, 1: no induction,...

The study investigated the amino acid and wound healing potentials of leaves Heterotis rotundifolia. Amino analysis was performed using HPLC. Total protein level, body weight histology were studied. Excision wound(2cm) induced on dorsal skin 75 wistar rats (176-308g) divided into five groups fifteen animals: control, 0.1g Vaseline, gentamicin (reference drug), extract+0.1g Vaseline (HRE1) 0.2g (HRE2). At end days 1, 7, 14 21, sacrificed blood collected for parameters while surface taken...

This study evaluated the bio-absorptive potentials of Pleurotus ostreatus and macerated cobs Zea mays in remediation crude oil polluted soil. Crude contaminated soil was collected from B-Dere community located Gokana L.G.A, Rivers State analyzed for physicochemical, Total petroleum hydrocarbon (TPH) Polycyclic aromatic hydrocarbons (PAHs) heavy metal. The sample divided into five parts 2,000 g each with following quantity mays, P. triton x- 00 added labeled thus: a) Polluted without...

The antidyslipidemic activity of Irvingia wombolu ethanol seeds extract was studied in high fat diet induced dyslipidemic rats.Forty five (45) Wstar rats were grouped into 5 groups 9 each. animals allowed 7 days acclimatization period. Group 1 the control group and it received normal rat chow water throughout study. Groups 2 to given for 14 after which they till end At days, not treated while 3-5 with 250, 500 1000mg/kg b.w respectively 28 days. lipid profile evaluated three times: first...

Gallic acid (GAL), rutin (RUT), and quercetin (QUE) are common antioxidant agents in fruits vegetables with intriguing pharmacological effects. In the present study, we compared therapeutic outcomes of GAL + QUE comparison RUT co-treatment a busulfan (BUS) model testicular injury Wistar rats. BUS (4 mg kg−1 body weight (b.w) was injected intraperitoneally daily for 4 days. or (20 b. w) delivered by oral gavage 52 Examination testes BUS-treated rats both biochemically under light microscopy...

The protective effect of Fe against Cd‐induced toxicity in the liver and kidney rats during concurrent administration both metals was investigated this study. Fifty female (130–150 g) were distributed into five groups 10 each ( n = 10): Group I (control), received normal saline solution; II (1.2 mg CdCl 2 /kg b.w.); III + 0.25 FeCl IV 0.75 V 1.5 b.w.). Administration tested substances lasted for 47 days. Cd injected intraperitoneally once a week, while administered to Cd‐exposed animals by...

Mucuna pruriens leaves are used in some part of Nigeria for the treatment malaria and anemia. With an estimated 3.3 billion people 97 countries territories at risk being infected with according to WHO, researching into new chemotherapeutic agent against this disease is indeed necessary. This study was designed evaluate antimalarial effect ethanol extract on NK65 chloroquine sensitive strain plasmodium berghei mice. The bioactive compounds were identified using GC-MS. experimental animals...

Allanblackia floribunda seed is one of the underutilized and under-exploited seeds in Nigeria, it a flowering plant clusiaceae family that has been used over years folk medicine especially managing hypertension Africa. This study seeks to evaluate phytoconstituents floribunda. Qualitative phytochemical screening, proximate analysis volatile compounds present were evaluated using standard methods. The screening showed presence alkaloids, flavonoids, tannins, triterpenoids saponins seeds....