A5007710569- Natural Antidiabetic Agents Studies
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Fatty Acid Research and Health
- Lipid metabolism and biosynthesis
- Liver Disease Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Phytoestrogen effects and research
- Biochemical effects in animals
- Metabolism, Diabetes, and Cancer
- Computational Drug Discovery Methods
- Free Radicals and Antioxidants
- Garlic and Onion Studies
- Pharmacological Effects of Natural Compounds
- Biochemical Acid Research Studies
- Antioxidants, Aging, Portulaca oleracea
- Herbal Medicine Research Studies
- Advanced Glycation End Products research
- Medicinal Plants and Neuroprotection
- Diet and metabolism studies
- Coconut Research and Applications
- Traditional and Medicinal Uses of Annonaceae
- Moringa oleifera research and applications
- Sirtuins and Resveratrol in Medicine
Bowen University
2022-2025
University of South Africa
2022-2025
Adeleke University
2018-2023
North-West University
2016-2020
University of Johannesburg
2014-2015
Cape Peninsula University of Technology
2012-2014
Introduction Infectious bursal disease (IBD), caused by the infectious Q8 virus (IBDV), is a highly contagious in young chickens, leading to immunosuppression with great economic importance. IBDV, non-enveloped bipartite dsRNA genome, infects bursa of Fabricius, causing severe gastrointestinal disease. Effective vaccines are urgently needed due limitations current oral vaccines, including degradation and low immunogenicity. This study designs evaluates multiepitope subunit vaccine using...
To investigate the role of red palm oil (RPO), rooibos tea extract (RTE) and their combined treatment (RPO + RTE) on antioxidant status in streptozotocin (STZ)-induced diabetic rats. Diabetes mellitus was induced by a single administration (50 mg/kg) rats were treated for 7 weeks. Antioxidant enzymes [catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)], capacity [trolox equivalence (TEAC), oxygen radical absorbance (ORAC)] as well total protein, albumin, globulin,...
AMP-activated protein kinase (AMPK) is known to regulate both glucose and lipid metabolism, which play vital roles in the development of metabolic syndrome. One way regulating AMPK through hormonal activation using adiponectin. Patients diagnosed with type-2 diabetes (T2D) obesity exhibit low adiponectin concentration levels their blood. Moreover, studies have also shown that inflammatory processes a significant role etiology these diseases. In this study, long-term effects neonatal intake...
Introduction: This study aimed to investigate the chemical profile of GC-MS, antioxidant, anti-diabetic, and anti-inflammatory activities ethyl acetate fraction Spilanthes filicaulis leaves (EFSFL) via experimental computational studies. Methods: After inducing oxidative damage with FeSO4, we treated tissues different concentrations EFSFL. An in-vitro analysis EFSFL was carried out determine its potential for activities. We also measured levels CAT, SOD, GSH, MDA. Results discussion:...
This study was carried out to investigate the in vitro antioxidant potentials of leaves and fruits Nauclea latifolia, a straggling shrub or small tree, native tropical Africa Asia. Hot water extracts latifolia were assessed for their total polyphenolic, flavanol, flavonol contents as well 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging ability, ferric reducing power (FRAP), Trolox equivalence capacity (TEAC), oxygen radical absorbance (ORAC) assays. The aqueous extract found contain higher...
Diabetes mellitus is a metabolic disorder caused by either the total destruction of pancreatic beta cells that secrete insulin for uptake glucose from circulation or as result inability body to respond presence in blood. The present study investigated effect flavonoid-rich fraction Monodora tenuifolia seed extract (FFMTSE) on blood parameters streptozotocin (STZ)-induced diabetic male Wistar rats. rats were divided into seven groups (n = 6). Group 1: normal control rats, 2: + FFMTSE (25...
Diabetes mellitus is a metabolic disease that poses serious global health challenge. The provision of alternative and complementary medicine to combat the has attracted attention numerous scientists. In this study, anti- α-glucosidase activities selected seven compounds obtained from Phyllanthus amarus leaves were explored using computational chemistry approach. absorption, distribution, metabolism excretion (ADME) properties compound with best binding affinity metformin examined....
Little is known about the effects of dietary intake red palm oil (RPO) on fatty acid composition in liver rats. Male Wistar rats randomly divided into four groups were fed with different doses oil. The control group received no oil; while experimental 1 ml, 2 ml and 4 daily for seven weeks. In all groups, palmitic (C16:0) followed by stearic (C18:0) predominantly present among saturated acids. Oleic (C18:1c) linoleic (C18:2) largely unsaturated There was significant (P<0.05) increase levels...
Metabolic syndrome, a cluster of different disorders which include diabetes, obesity and cardiovascular diseases, is global epidemic that growing at an alarming rate. The origins disease can be traced back to early developmental stages life. This has increased mortalities continues reduce life expectancies individuals across the globe. aim this study was investigate sub-acute long term effects neonatal oral administration oleanolic acid metformin on lipids (free fatty acids, FFAs) genes...
Nutritional manipulations in the neonatal period are associated with development of negative or positive health outcomes later life. Excessive fructose consumption has been attributed to increase global prevalence metabolic syndrome (MetS) and oxidative stress. Oleanolic acid (OA) anti-diabetic anti-obesity effects. We investigated protective potential orally administering OA period, prevent fructose-induced stress, adverse maturation gastrointestinal tract (GIT) suckling rats. Seven-day old...
Activation of calmodulin dependent protein kinase (CaMK)II by exercise is beneficial in controlling membrane lipids associated with type 2 diabetes and obesity. Regulation lipid metabolism crucial the improvement obesity symptoms. The role CaMKII was focus this study. Five to six weeks old male Wistar rats were used GC×GC-TOFMS technique determine levels polyunsaturated fatty acids (linoleic acid, arachidonic acid 11,14-eicosadienoic acid). Carnitine palmitoyltransferase (Cpt-1) acetyl-CoA...
South Africa. This study investigated the nutritional and chemical compositions of four whitefleshed (Blesbok, Ndou, Monate, Mvuvhelo) three orange-fleshed (Bophelo, Impilo, 199062.1) cultivars. The protein, ash, crude fibre contents were analysed using standard AOAC procedures. detection fatty acids, sugar, metabolites was carried out Gas Chromatography–Mass Spectrometry (GC-MS). Carbohydrate energy values determined methods. results showed that Bophelo had highest protein content...
Diabetes mellitus is a metabolic disease in which the body unable to produce insulin or respond production, consequently leading abnormal metabolism of carbohydrates, lipids and proteins causing elevation glucose blood. Oxidative stress, an imbalance between production free radicals antioxidant system has been implicated pathogenesis diabetes. Free attack important macromolecules cell damage. Antioxidants are intimately involved prevention damage caused by radicals. The anti-diabetic effects...
Artesunate toxicity has been linked to increased production of reactive oxygen species resulting in oxidative stress, which implicated the pathogenesis many chronic diseases. This study evaluated effects hydroethanolic extract Syzygium aromaticum buds (HESAB) on serum antioxidant status and lipid profiles Wistar rats with artesunate toxicity. Forty-eight male (150–200 g) randomized into six groups (n = 8) were treated as follows for 21 days: Group 1 (Control; DMSO); 2 (Artesunate, 15 mg/kg...
The effect of neonatal oral supplementation oleanolic acid (OA) on peroxisome proliferator-activated receptor gamma (PPARγ)-1 glucose homeostasis in high fructose-fed rats was investigated. Rat pups (7 days old) were randomly assigned to and administered with control (Distilled water, DW), OA (60 mg/kg), metformin (MET, 500 fructose solution (HFS, 20% w/v), + HFS, MET treated till postnatal day (PND) 14. weaned onto a standard diet PND 21 up 111 terminated 112. Glucose derivatives gene...
Background: There is an increasing need for botanicals to be used as alternative and complementary medicine in the management of male infertility. Male infertility has been a major health/social challenge people all over world. This study, therefore, investigated ameliorative potential hydroethanolic leaf extract Parquetina nigrescens (HELEPN) against d-galactose-induced testicular injury. Methods: Thirty Wistar rats were randomly allotted into six groups (n = 5). Group I (Normal control),...