A5024128391- Viral Infections and Vectors
- Pharmacological Effects of Natural Compounds
- Herbal Medicine Research Studies
- Natural Antidiabetic Agents Studies
- Vector-borne infectious diseases
- Reproductive Biology and Fertility
- Phytoestrogen effects and research
- Phytochemicals and Antioxidant Activities
- Bat Biology and Ecology Studies
- Ovarian function and disorders
- Vector-Borne Animal Diseases
- Bioactive Compounds and Antitumor Agents
- Eicosanoids and Hypertension Pharmacology
- Cocoa and Sweet Potato Agronomy
- Glutathione Transferases and Polymorphisms
- Cholinesterase and Neurodegenerative Diseases
- Medicinal Plants and Neuroprotection
- Phytochemical compounds biological activities
- Pesticide Exposure and Toxicity
- Medicinal Plants and Bioactive Compounds
- Folate and B Vitamins Research
- Cassava research and cyanide
- Plant Molecular Biology Research
- Complementary and Alternative Medicine Studies
- Moringa oleifera research and applications
Bowen University
2022-2024
Introduction: This study aimed to investigate the chemical profile of GC-MS, antioxidant, anti-diabetic, and anti-inflammatory activities ethyl acetate fraction Spilanthes filicaulis leaves (EFSFL) via experimental computational studies. Methods: After inducing oxidative damage with FeSO4, we treated tissues different concentrations EFSFL. An in-vitro analysis EFSFL was carried out determine its potential for activities. We also measured levels CAT, SOD, GSH, MDA. Results discussion:...
The nutritional as well beneficial effects of the Artocarpus communis seed on metabolic syndrome complications have not been studied. In this research, aim was to investigate composition and seeds' phytoconstituents p53 core, fat mass obesity-associated (FTO) protein cytochrome P450 CYP11A1 domains. elements phytochemicals in were determined through atomic absorption spectroscopy assay gas chromatography-mass spectrometry (GC-MS) analysis, respectively. Also, compounds detected docked FTO...
Polycystic ovarian syndrome (PCOS) is a prevalent endocrine illness that affects 5-10% of reproductive women globally. It multifaceted hormonal disorder characterized by the involvement numerous molecular mechanisms contribute to its development. This study investigates effect <em>Artocarpus communis </em>seed on imbalance and P53, IRS, HsD17β2, FTO, CYP11a genes expression in ovaries letrozole-induced polycystic rats. To induce PCOS 30 female Wistar rats, letrozole was...
Alzheimer's disease (AD) is an age-associated neurodegenerative condition marked by amyloid plaques, synaptic dysfunction, and neuronal loss. Besides conventional medical care, herbal therapies, both raw refined, have attracted researchers for their potential therapeutic effects. As a proof-of-concept, our study combined HPLC-DAD analysis of bioactive constituents, network pharmacology, molecular dynamics (MD), docking, post-MD analysis, experimental verification to investigate the...
Annona muricata L. peel has been recognized for many ethnobotanical uses, including diabetes management. However, limited detailed scientific information about its mechanism of antidiabetic activity exists. The objective this study was to evaluate the anti-diabetic properties an aqueous extract A. (AEAMP) and action on alloxan-induced diabetic rats.In vitro assays, such as α-amylase α-glucosidase were analyzed AEAMP. Alloxan monohydrate (150 mg/kg b.w) used induce in rats. 150 b.w positive...
Spilanthes filicaulis (Schumach. & Thonn.) C. D Adam is a shrubby plant of the Asteraceae family that has medicinal benefits for pharmaceutical and cosmetic industries.
This study examines the nutritional composition, phytochemical profiling, and antioxidant, antidiabetic, anti-inflammatory potential of a methanolic extract Spilanthes filicaulis leaves (MESFL) via in vitro, ex vivo, silico studies. In vitro activities were examined. vivo study, liver tissues subjected to FeSO4-induced oxidative damage treated with varying concentrations MESFL. MESFL contains reasonable amount nitrogen-free extract, moisture, ash content, crude protein, fat, lesser fiber....
Abstract Various derivatives of cinnamic acid have been reported to possess significant activities such as antioxidant and hepatoprotective, neuroprotective activities. Interestingly, testicular toxicity has linked several causes, with oxidative damage being one the pathophysiological mechanisms. 3-(4-methoxyphenyl) acrylic ( 1 ), a derivative acid, was synthesized then investigated for its effects on iron-induced injury stress via ex vivo in silico studies, respectively. Evaluations were...
We investigated ectoparasite diversity, interspecific infestation rates and host preference in roosting fruit bats, Eidolon helvum, from Bowen University, Southwest Nigeria. Fur of captured E. helvum were sampled monthly for ectoparasites January 2021 to June 2022. examined a total 231 observed significant female male adult sex ratio (0.22:1); with 53.9% ectoparasitic rate. identified enumerated the ectoparasite; subjected its Cytochrome c oxidase subunit I (COI) gene phylogenetic analysis...
This study aimed to examine the therapeutic activity of cinnamic acid derivative KAD-7 (N'-(2,4-dichlorobenzylidene)-3-(4-methoxyphenyl) acrylohydrazide) on Fe2+-induced oxidative hepatic injury via experimental and computational models. In addition, role ATPase ectonucleoside triphosphate diphosphohydrolase (ENTPDase) in coordination cellular signals is speculated upon proffer suitable therapeutics for metabolic stress disorder their inhibition. While we know little about with flexible dual...
Counteraction of adriamycin-induced alterations in cardiac enzymes by Thespesia populnea leaf extractSangeetha Lakshmi A. Rajbanshi, Archana N. Paranjape, Vasu Appanna
Insufficiencies in insulin secretion and/or action cause diabetes mellitus (DM), a complex condition characterized by abnormal blood glucose levels. Diabetes is often treated modifying either metabolism, lipids or both. A direct correlation has been found between high levels of lipid peroxide individuals with and lower intracellular antioxidant activity. Therefore, this study was designed to investigate the effect aqueous extract Kigelia africana fruit on carbohydrate hydrolyzing enzyme,...
Herbal extracts are an effective treatment for polycystic ovarian syndrome (PCOS) and have been shown to improve insulin resistance, hyperandrogenism, sex hormones, ovulation, PCOS symptoms. Artocarpus communis seed's potential effects on ovary not studied. This research aims investigate the beneficial of seeds induced by letrozole in Wistar rats. To induce PCOS, female rats weighing between 160g 250g were administered (1 mg/kg) 21 days. Subsequently, 12 days, given seed methanol extract,...
The effects of N'-(2,6-dimethoxybenzylidene)-3-(4-methoxyphenyl) acrylohydrazide (KAD 9) on iron-induced cardiac injury was investigated. Evaluations the iron chelating capability, ferric-reducing antioxidant power (FRAP), as well DPPH free radical scavenging activity KAD 9 were performed. oxidative induced by 0.1 mM FeSO4 treaed with varied doses ex vivo. Comparing to conventional quercetin, ability significantly rises concentration (p<0.05). generated, and this resulted in decreased...
Abstract Objectives This study investigated the antidiabetic effects of methanolic extract E. africanum (MEEA) stem bark on streptozotocin (STZ)-induced diabetic nephropathy (DN) in Wistar rats. Methods The vitro enzyme (α-amylase) inhibitory activity MEEA was measured using a standard procedure. Diabetic rats with fasting blood glucose above 250 mg/dL were considered and divided into following groups: control (distilled water-treated), diabetic-control, metformin (100 mg/kg), diabetes +...
Abstract Theileria is an haemoparasitic protozoa causing disease known as theileriosis in animals. The transmitted by tick vectors. circulates cattle and causes the dairy industry to suffer significant financial losses it affects milk livestock production, especially sub-Saharan region. endoparasite can exist sub-clinical state that are carriers, these transmit diseases become reservoir of infection for ticks. In Nigeria, diagnosis this parasite has been done mainly through light microscopy...
Abstract There is great diversity of ticks with only three genera; Amblyomma, Hyalomma , and Rhipicephalus known to have highest impact on livestock health. Ticks suck blood release toxic secretions from saliva through their mouth appendage into cattle resulting in anaemia, skin damage, inflammation, paralysis, reduced weight gain, reduction milk production. Proper tick identification imperative understand tick-borne pathogens as well determine control measures. Molecular approach has made...