A5045385575- Moringa oleifera research and applications
- Chemotherapy-induced organ toxicity mitigation
- Drug-Induced Hepatotoxicity and Protection
- Heavy Metal Exposure and Toxicity
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Medicinal Plants and Neuroprotection
- Nanoparticles: synthesis and applications
- Alzheimer's disease research and treatments
- SARS-CoV-2 and COVID-19 Research
- Sperm and Testicular Function
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Aluminum toxicity and tolerance in plants and animals
- Chemotherapy-induced cardiotoxicity and mitigation
- Piperaceae Chemical and Biological Studies
- Alcoholism and Thiamine Deficiency
- Cancer-related cognitive impairment studies
- Herbal Medicine Research Studies
- Liver Disease and Transplantation
- Biomarkers in Disease Mechanisms
- Phytochemistry and Bioactivity Studies
- Diet, Metabolism, and Disease
- Aquatic Ecosystems and Biodiversity
- Bioactive natural compounds
Kwara State Polytechnic
2019-2024
University of Ilorin
2017-2021
Central Research Laboratories (United Kingdom)
2019
The treatment of diabetes involves the use herbal plants, attracting interest in their cost-effectiveness and efficacy. An aqueous extract Persea americana seeds (AEPAS) was explored this study as a possible therapeutic agent rats with mellitus. induction achieved by injecting 65 mg/kg body weight (BWt) alloxan along 5% glucose. This conducted using thirty-six (36) male Wistar rats. animals were divided into 6 equal groups, (n = 6) treated for 14 days. In vitro assays total flavonoid,...
Objective: Gentamicin is an efficacious aminoglycoside antibiotic widely used to treat life-threatening Gram-negative bacteria infections. However, its specific non-targeted induction of nephrotoxicity a worrying clinical challenge. The study explored the nephroprotective effect Moringa oleifera seed oil (MOO) against gentamicin-induced oxidative nephrotoxicity, pro-inflammation, and apoptosis in male Wistar rats.Method: Twenty-four rats divided into 4 groups (n = 6) were administered MOO (5...
The management of diabetes over the years has involved use herbal plants, which are now attracting interest. We assessed antidiabetic properties aqueous extract
Background: Stress during pregnancy significantly impacts offspring early physiological programming. Herbal remedies are frequently used by pregnant women to enhance their wellbeing. Moringa oleifera Leaf Extract (MoLE) is believed have both anti-stress and antioxidant properties which can act as a Selective Estrogen Receptor Modulator (SERM) that regulate activities of estrogen, different effects on tissues. Goal this study compile information molecular docking analysis phytochemicals found...
The off-target testicular toxicity of the anticancer drug, cisplatin, is a current clinical concern and worrisome to male cancer patients. Growing evidence has implicated oxidative stress inflammation in cisplatin toxicity. We have explored whether fresh ginger juice could mitigate induced by drug rats. Rats were subjected oral administration (5 ml/kg body weight/day) for 5 days against damage single ip injection (CIS) (10 mg/kg weight) on day 2 only. Testicular activities antioxidant...
5-Fluorouracil (5-FU) is a strong anticancer agent commonly used for the treatment of various malignancies. However, its clinical utility countered by non-targeted nephrotoxicity and hepatotoxicity which sometimes unbearable cancer patients. Accumulating evidence has implicated oxidative stress pro-inflammation in 5-FU toxicity. The study explored whether Moringa oleifera seed oil (MOO) could protect against 5-FU-induced mechanism action Wistar rats. Rats were subjected to prophylactic oral...
This study examines the nutritional composition, phytochemical profiling, and antioxidant, antidiabetic, anti-inflammatory potential of a methanolic extract Spilanthes filicaulis leaves (MESFL) via in vitro, ex vivo, silico studies. In vitro activities were examined. vivo study, liver tissues subjected to FeSO4-induced oxidative damage treated with varying concentrations MESFL. MESFL contains reasonable amount nitrogen-free extract, moisture, ash content, crude protein, fat, lesser fiber....
Data available support that ninety percent of male infertility cases are due to low sperm counts. There is a scarcity data on the medicinal effects cannabis fertility. This study evaluated testicular function and quality modulation with in rats.Twenty-five Wistar rats were randomly grouped into five: A, B, C, D, each group have 5 rats. A (control): 0.2 ml 2% DMSO, B (vitamin C): 90 mg/kg body weight, E administered: mg/kg, 10 20 weight ethanolic leaf extract (ELEC) respectively. The...
Recent evidences suggest that cerebellar degeneration may be associated with the development of Alzheimer's disease (AD). However, previous reports were mainly observational, lacking substantial characterization cellular and molecular features during AD progression.This study is aimed at characterizing cerebellum in rat models assessing corresponding neuroprotective mechanisms Garcinia biflavonoid complex (GBc).Male Wistar rats grouped treated alone or combination PBS (ad libitum)/day, corn...
Some therapeutic and beneficial health properties of the Theobroma cacao leaf have been documented. This study evaluated ameliorative effect cacao-fortified feed against potassium bromate-induced oxidative damage in male Wistar rats. Thirty rats were randomly grouped into A-E. Except for E (the negative control), other groups administered 0.5 ml 10 mg/kg body weight bromate daily using oral gavage then allowed access to water ad libitum. Groups B, C, D fed with %, 20 30 % leaf-fortified...
Consumption of bread can be associated with some health issues, which improved by fortifying it plants that are good sources nutrients and bioactive compounds. This study investigated the effects 3 leafy vegetables on quality Nigerian wheat bread. Leave powders coriander, moringa, amaranths were added to dough at 0% (control), 1%, 3%, 5%, or 7%, blends obtained used bake vegetable breads, then analyzed for proximate, minerals, total phenolics, antioxidant activity, reducing sugars, glycemic...
Cyclophosphamide (CYP) is a potent DNA-interactive anticancer drug; however, its clinical drawbacks are chiefly associated with induction of oxidative multi-organ toxicity. Sitagliptin (STG) an antidiabetic dipeptidyl peptidase-4 inhibitor drug antioxidant efficacy. Herein, we have explored whether STG could abrogate the CYP-induced stress-mediated cardiac and hepatorenal toxicities in male rats. (20 mg/kg, o.p) was administered to rats for 5 consecutive days against organ induced by CYP...
This study evaluated the prospective molecular and biochemical mechanisms behind hepatoprotective effects of curcumin in Wistar rats exposed to KBrO3. Techniques for assessment hepatic oxidative injury histological biomarkers were used. The concentrations proteins connected with inflammation (e.g. tumor necrosis factor-alpha (TNF-α), interleukins 1β (IL-1β) C-reactive protein (CRP)) estimated by enzyme-linked immunosorbent assay (ELISA) techniques. Results showed that, administered orally at...
Increasing concern has been expressed about the declining sperm count of humans and potential fertility effects clomiphene citrate, a synthetic oestrogen-antagonist on human reproductive health in last few decades. This study aims to investigate influence cashew nut supplemented diet activity citrate male rats. The rats were divided into six groups n = 6: fed basal diet; then given (cc) orally; with 10% processed cc rat 20% for fourteen days. results revealed that there was significant (p <...
The emergence of 2019 novel Coronavirus (COVID-19 or 2019-nCoV) has caused significant global morbidity and mortality with no consensus specific treatment. We tested the hypothesis that FDA-approved antiretrovirals, antibiotics, antimalarials will effectively inhibit COVID-19 two major drug targets, coronavirus nucleocapsid protein (NP) hemagglutinin-esterase (HE). To test this hypothesis, we carried out a phylogenic analysis genome to understand origins NP HE, also modeled proteins before...
Exposure to several stressors and other lifestyle factors converge affect the chemistry, structure, function of body tissues over time. Chronic unpredictable stress (CUS) protocol has been widely used study impact exposure in animal models. Moringa oleifera leaf extract (MOLE) is known have hepatoprotective antioxidant properties. The aimed determine effect administration MOLE during conditions chronic on histology reproductive organs, heart liver. Twenty mature inbred healthy virgin female...
There is a growing concern recently on the effect of synthetic drugs human health and environment. This has led to search for natural antimicrobial agents. In this research, antifungal antioxidant properties ethanolic extract derived from potato peels as potential preservatives fruits like mango was examined. The were collected, processed, extracted using ethanol (70 %), with phytochemical composition analyzed Gas Chromatography-Mass Spectrometry (GC-MS) Fourier Transform Infrared...
Abstract Background: Cadmium (Cd) is an established carcinogen. Neurotransmitter-cancer interaction, tissue innervation, and angiogenesis impact strongly on cancer prognosis, metastasis, survival. Objectives: This study evaluated the anticancer potentials of MO11 (isolated from Moringa oleifera leaves) MS06 Musa sapientum suckers) against Cd Chloride (CdCl)-induced skin carcinogenesis in rats. Materials Methods: Twenty-eight adult male Wistar rats (average weight 155 g) were randomly divided...