A5090108864- Sperm and Testicular Function
- Cannabis and Cannabinoid Research
- Heavy Metal Exposure and Toxicity
- Toxoplasma gondii Research Studies
- GABA and Rice Research
- Trace Elements in Health
- Natural Compound Pharmacology Studies
- Diverse Scientific Research Studies
- Garlic and Onion Studies
- Computational Drug Discovery Methods
- Malaria Research and Control
- Heavy Metals in Plants
- Ethnobotanical and Medicinal Plants Studies
- Hibiscus Plant Research Studies
- Food Drying and Modeling
- Ginger and Zingiberaceae research
- Aldose Reductase and Taurine
- Ion Channels and Receptors
- Animal Diversity and Health Studies
- Therapeutic Uses of Natural Elements
- Medicinal plant effects and applications
- Extraction and Separation Processes
- Plant Toxicity and Pharmacological Properties
- Nuclear Structure and Function
- Food and Agricultural Sciences
Landmark University
2016-2024
The Trypanosoma and Toxoplasma spp, are etiological agents of diseases capable causing significant morbidity, mortality economic burden, predominantly in developing countries. Currently, there no effective vaccines for the caused by these parasites; therefore, therapy relies heavily on antiprotozoal drugs. However, treatment options parasitic limited, thus underscoring need new anti-protozoal agents. Here, we investigated anti-parasite action nanoparticles. We found that nanoparticles have...
The emergence of varying levels resistance to currently available antimalarial drugs significantly threatens global health. This factor heightens the urgency explore bioactive compounds from natural products with a view discovering and developing newer novel mode actions. Therefore, we evaluated inhibitory effects sixteen phytocompounds
Allium cepa Linn (Onion) Organosulfuric compounds and phytonutrients have medicinal benefits. The study estimated the antioxidant effect of in fortified feed against oxidative damage caused by potassium bromate. Commercial was substituting 10 %, 20 30 % rat's daily ration with respective portion pulverized cepa. Potassium bromate administered orally to rats all groups except normal control. test were allowed access ad libitum. animals sacrificed; consequently, serum, liver, kidney obtained...
Erectile dysfunction (ED) is one of the main challenges occurring among men worldwide, and characterised by trouble getting or keeping steady erection during sexual intercourse. Various drugs like sildenafil, a phosphodiesterase-5 inhibitor (PDE-5) are freely available in pharmacies, though normally associated with several adverse. This study was designed to assess molecular relations obtainable between catechin, garcinal, garcinoic acid d-tocotrienol compounds isolated from Garcinia kola...
To evaluated the antioxidant and protective effect of Thaumatococcus daniellii (T. daniellii) on rat feed potassium bromate (KBrO3) toxicity in male testes. Thirty albino rats average weight 140 ± 5 g were randomly grouped into with six per group. The group A (positive control) test groups (C, D E) orally given 0.5 mL 10 mg/kg body KBrO3 daily. animals negative control (group B) positive fed commercial while tests 10%, 20% 30% T. leaf respectively. treatment was carried out for 14 days...
Alcoholism has been linked to problems with male reproductive function. The combined effects of alcohol, cannabis, and tobacco were compared in this study. A total 35 rats assigned randomly into seven groups A-G: animals administered distilled water. Animals B-G either alcohol orally (30 ml 40% alcohol) or exposed smoke from ignited (exposure 0.7 g for 5 min) cannabis min): B (orally alcohol), C (exposed the tobacco), D cannabis), E (treated F G smokes cannabis). Assays carried on testicular...
The low constitutive activation of Liver X receptor, an endogenous nuclear receptor with two subtypes (α and β), is a condition lying at the crossroad cancer cardiovascular disease. Both natural synthetic agonists have reportedly shown remarkable antiproliferative atheroprotective effects but repeated doses its ones are also paradoxically associated hyperlipidaemic neurotoxicity, though attributed to alpha subtype. This highlights need for novel, safe, potent LXR-beta-selective agonists....
Essential oils (EOs) are known to possess lethal effects on various pests and insects ecologically safe. The larvicidal adulticidal activities of Helianthus annuus (L.) seed EO (HASEO) against Aedes aegypti mosquitoes in silico inhibitory action its GCMS constituents Ae. acetylcholinesterase (AChE) were investigated. Larvae adult (320 each) grouped into 4 (A - D) exposed DMSO, 1500, 3000 4500 ppm HASEO DMSO respectively. Mortality was recorded after 0, 15, 30 45 min. exhibited stronger...
The development of an effective and affordable malaria treatment drug is required to reduce the number deaths caused by this disease around world. in-vivo anti-malarial activities Cannabis were investigated, as well in-silico antimalarial prediction cannabis GC–MS compounds. Thirty albino mice divided into six groups five animals each at random: A, B, C, D, E F. in all except normal control group infected with Plasmodium berghei NK-65 before commencement treatment. Each was treated...
Data available support that ninety percent of male infertility cases are due to low sperm counts. There is a scarcity data on the medicinal effects cannabis fertility. This study evaluated testicular function and quality modulation with in rats.Twenty-five Wistar rats were randomly grouped into five: A, B, C, D, each group have 5 rats. A (control): 0.2 ml 2% DMSO, B (vitamin C): 90 mg/kg body weight, E administered: mg/kg, 10 20 weight ethanolic leaf extract (ELEC) respectively. The...
The in vitro antimicrobial and vivo heavy metal abatement properties of aqueous extracts Garcinia kola Heckel (bitter cola) were investigated using opportunistic pathogens Wistar rats as experimental models. A marked inhibitory activity against Aspergillus niger, flavus Candida albicans was recorded at 100 mg/ml the crude relative to ketoconozole fluconazole drugs. Similarly, different concentrations (25 mg/ml, 50 mg/ml) bitter cola inhibited species Escherichia coli Pseudomonas aeruginosa...
Context: Cadmium has been considered as one of the most hazardous toxic compounds with harmfully effect on health organisms. Aims: To evaluate effects gallic acid (GA) cadmium-induced liver and renal oxidative stress in Wistar rats. Methods: Twenty rats were grouped into four (A–D) five Rats Group A, B, C D administered distilled water, 5 mg/kg bw cadmium chloride (CdCl2), CdCl2 + GA concurrently (20 bw) respectively for 14 days. Biochemical parameters such antioxidant enzyme activities,...
Some therapeutic and beneficial health properties of the Theobroma cacao leaf have been documented. This study evaluated ameliorative effect cacao-fortified feed against potassium bromate-induced oxidative damage in male Wistar rats. Thirty rats were randomly grouped into A-E. Except for E (the negative control), other groups administered 0.5 ml 10 mg/kg body weight bromate daily using oral gavage then allowed access to water ad libitum. Groups B, C, D fed with %, 20 30 % leaf-fortified...
Wheat bran, groundnut shell, watermelon peel and corn bran were analyzed for chemical composition amino acid profile. A feeding trial was conducted to assess their effect on biochemical profile liver histology of rats. Watermelon obtained the highest dry matter content (91.93±0.03 g/100g), followed by shell meal (89.57±0.31 g/100g). Carbohydrate ranged between 35.28±0.08 g/100g 65.19±0.13 g/100g. Crude protein 6.53±0.06 (groundnut meal) 10.88±0.02 (wheat bran). Liver histopathology revealed...
Soaking and incorporation of legumes for fortification are essential to a complementary food production process. Cassava, orange-fleshed potato, cowpeas sustainably cheap, locally available, underutilized biofortification. This study investigated the effect cowpea soaking time (3, 6, 9 h) on different composition ratios cassava, cowpea, sweet potato (CCP) blends (50 : 40 10 (EC), 50 30 20 (FC), (GC), 0 (HC)). Each blend was assayed pH, antinutrient, antioxidant, proximate contents. Results...
Abstract In furtherance to the search for reliable and cost-effective road construction materials which is expected engender development of sustainable less expensive pavements, coupled with increase in agricultural wastes due current rise consumption white meat, this research investigated engineering properties modified bitumen subsequent performance asphaltic concrete incorporating Pulverized Snail Shell Ash (PSSA) as strength modifier filler. order achieve specific objectives, preliminary...
Dietary and environmental exposure to acrylamide (ACR) has been linked with liver kidney illnesses, cardiopulmonary diseases, neurological problems. Nevertheless, gallic acid (GA) is a potent polyphenolic compound many therapeutic attributes. This present research explored the protective effect of GA against ACR hepato-renal toxicity. treatment was initially for 7 days followed by subsequent co-administration further 21 days. Twenty-four male Wistar rats were randomly distributed into six...