A5085736974- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Neuroprotection
- Heavy Metal Exposure and Toxicity
- Drug-Induced Hepatotoxicity and Protection
- Moringa oleifera research and applications
- Essential Oils and Antimicrobial Activity
- Diet, Metabolism, and Disease
- Trace Elements in Health
- Nanoparticles: synthesis and applications
- Diverse Scientific Research Studies
- Herbal Medicine Research Studies
- Natural Compound Pharmacology Studies
- Cholinesterase and Neurodegenerative Diseases
- Phytochemistry and Biological Activities
- Effects and risks of endocrine disrupting chemicals
- Chemotherapy-induced organ toxicity mitigation
- Pharmacological Effects of Medicinal Plants
- African Botany and Ecology Studies
- Garlic and Onion Studies
- Papaya Research and Applications
- Pancreatic function and diabetes
- Phytochemistry and Bioactivity Studies
Ekiti State University
2014-2024
Bowen University
2022
Landmark University
2020-2022
Afe Babalola University
2016-2018
The treatment of diabetes involves the use herbal plants, attracting interest in their cost-effectiveness and efficacy. An aqueous extract Persea americana seeds (AEPAS) was explored this study as a possible therapeutic agent rats with mellitus. induction achieved by injecting 65 mg/kg body weight (BWt) alloxan along 5% glucose. This conducted using thirty-six (36) male Wistar rats. animals were divided into 6 equal groups, (n = 6) treated for 14 days. In vitro assays total flavonoid,...
Neurodegenerative diseases, for example Alzheimer’s, are perceived as driven by hereditary, cellular, and multifaceted biochemical actions. Numerous plant products, flavonoids, documented in studies having the ability to pass blood-brain barrier moderate development of such illnesses. Computer-aided drug design (CADD) has achieved importance discovery world; innovative developments aspects structure identification characterization, bio-computational science, molecular biology have added...
Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and range of other symptoms that last for long period time. It has rapid prevalence globally, there possibility the statistic doubling in few years. This review aimed at evaluating mechanism, pathophysiology, pharmacology diabetes mellitus. The data used was sourced through thorough scientific articles published variety databases, including Springer, Scopus, Elsevier, Google Scholar, Wiley, Web Science,...
Cadmium is a highly neurotoxic heavy metal that disrupts membranes and causes oxidative stress in the brain. The study aimed to investigate neuroprotective effect of gallic acid on damage brains Wistar rats exposed cadmium chloride (CdCl2). Male were divided into four groups five each. Group 1 was administered distilled water only throughout study. Throughout study, 2 received CdCl2 alone (5 mg/kg b.w./day), 3 (20 4 + mg/kg). Treatments oral with as vehicle. lasted 21 days. In brain,...
The management of diabetes over the years has involved use herbal plants, which are now attracting interest. We assessed antidiabetic properties aqueous extract
Tithonia diversifolia (Hemsl.) A. Gray leaves have long been used to manage neurodegenerative diseases without scientific basis. This study characterized the phenolic constituents, evaluated antioxidant properties of extracts from T. as traditional medicine in Africa and its inhibition key enzymes linked Alzheimer's disease. The extract was rich acids (gallic acid, chlorogenic caffeic acid p-coumaric acid) flavonoids (apigenin) had 1,1-diphenyl-2-picryl-hydrazil radical scavenging abilities...
Ocimum gratissimum L. is a medicinal plant widely grown in tropical and subtropical regions with the leaf decoction usually taken folk medicine to enhance erectile performance men although probable mechanism of actions remains undetermined. This study examined inhibitory potentials leaves on some key enzymes associated dysfunction penile testicular tissues rat.Inhibitory effect aqueous extract (1:10 w/v) O. activities phosphodiesterase-5 (PDE-5), arginase, angiotensin I -converting enzyme...
Cadmium has been considered a risk factor for humans as it accumulates in body tissues, such the liver, lungs, kidneys, bones, and reproductive organs. The aim of present study was to evaluate effect Irvingia gabonensis (IG) against cadmium (Cd)-induced nephrotoxicity. performed on twenty (20) male rats divided into four groups: control group, group (4 mg/kg/day, intraperitoneally), + extract (200 mg/kg weight by oral gavage) (400 gavage). Changes kidney biochemical markers, namely...
Therapies directed towards controlling hyperglycemia, the hallmark of type-2 diabetes mellitus, go a long way in managing and its related complications. Reducing glucose level through inhibition relevant carbohydrate hydrolyzing enzymes is one among many routes management diabetes. This study investigates vitro enzyme inhibitory antioxidant properties solvent-partitioned fractions Spondias mombin Mangifera indica leaves; which are used extensively treatment diabetic patients locally. The...
Diabetes mellitus is a major, rapidly growing endocrine disorder in most countries. The high cost and side effects of conventional drugs for the management this disease have shifted attention to medicinal plants.
The worldwide expanding increment in cancer pervasiveness is disturbing and this disease ranks among the main causes of mortality both developing developed countries. Unfortunately, available treatment options come with serious side effects do not guarantee complete success. Although numerous models have been proposed for development better therapeutic agent, however exact mechanism are still poorly understood. This then calls continued research aimed at new drugs as an alternative or...
The emergence of varying levels resistance to currently available antimalarial drugs significantly threatens global health. This factor heightens the urgency explore bioactive compounds from natural products with a view discovering and developing newer novel mode actions. Therefore, we evaluated inhibitory effects sixteen phytocompounds
Introduction: This study aimed to investigate the chemical profile of GC-MS, antioxidant, anti-diabetic, and anti-inflammatory activities ethyl acetate fraction Spilanthes filicaulis leaves (EFSFL) via experimental computational studies. Methods: After inducing oxidative damage with FeSO4, we treated tissues different concentrations EFSFL. An in-vitro analysis EFSFL was carried out determine its potential for activities. We also measured levels CAT, SOD, GSH, MDA. Results discussion:...
Abstract Background In West Africa, the fruit, seed, leaf and stem of Blighia sapida K.D. Koenig are commonly used as remedy against a variety diseases, including diabetes mellitus. This study investigated ameliorative potential B. bark ethanol extract pancreatic β-cell dysfunction in diabetic rats. Methods Diabetes was induced by intraperitoneal injection alloxan (65 mg/kg body weight) for 21 days, orally administered with glibenclamide (5 weight), 50–150 weight once daily days. Results The...
Over the years, due to remarkable functional properties, nanoparticles have been widely used and being tested in treatment diagnosis of diseases such as cancer, diabetes, etc. The green synthesis these can be achieved by physical, chemical, biological methods. Nanoparticles biosynthesis is put forth advantageous over chemical physical methods because it non or minimally toxic, environmentally friendly, cost-effective. A an approach that connects nanotechnology with plants, microorganisms,...
The purpose of this study was to investigate the therapeutic activity cinnamic acid derivative KAD-3 (ethyl 3-(4-methoxyphenyl) acrylate) on Fe2+-induced oxidative hepatic damage via experimental and computer aided studies. Oxidative induced incubation tissue supernatant with 0.1 mM FeSO4 for 30 min at 37 °C ex vivo different concentration KAD-3. Molecular docking, ADMET profiling, density functional theory were conducted candidate filter properties drug design. GSH, CAT, ENTPDase activities...
The purpose of this study was to investigate the protective effect Beta vulgaris leaf extract (BVLE) on Fe2+-induced oxidative testicular damage via experimental and computational models. Oxidative induced incubation tissue supernatant with 0.1 mM FeSO4 for 30 min at 37 °C. Treatment achieved by incubating tissues BVLE under same conditions. catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO) levels, acetylcholinesterase (AChE),...
In Africa, the fruit, leaf, seed and roots of Carica papaya Linn. are generally used to treat a variety diseases such as malaria, cancer, cardiovascular diseases. this study, we evaluated protective potentials aqueous extract C. on arsenic-induced biochemical genotoxic effects in Wistar rats. Rats were induced intraperitoneal with sodium arsenate (dissolved distilled water at 3 mg/kg body weight) for 21 days animals administered simultaneously 200 weight vitamin C, 100 150 root once daily...