A5074618036- Oral and Maxillofacial Pathology
- Hair Growth and Disorders
- Computational Drug Discovery Methods
- Cancer Genomics and Diagnostics
- Global Health and Surgery
- Skin and Cellular Biology Research
- Oral Health Pathology and Treatment
- Head and Neck Cancer Studies
- Advanced Proteomics Techniques and Applications
- Cancer Cells and Metastasis
- Mathematical Biology Tumor Growth
- Tumors and Oncological Cases
- Molecular Biology Techniques and Applications
- Cervical Cancer and HPV Research
- Systemic Sclerosis and Related Diseases
- Mass Spectrometry Techniques and Applications
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Dermatologic Treatments and Research
- MicroRNA in disease regulation
- Bone Tumor Diagnosis and Treatments
- melanin and skin pigmentation
- Genetics, Bioinformatics, and Biomedical Research
- Advanced Biosensing Techniques and Applications
- COVID-19 and healthcare impacts
University of Cape Town
2015-2024
Groote Schuur Hospital
2017-2024
Tygerberg Hospital
2017-2023
University of the Western Cape
2017-2023
International Centre for Genetic Engineering and Biotechnology
2014-2017
International Centre for Genetic Engineering and Biotechnology
2015
Niigata University
2011-2012
To summarize and discuss how geriatric dentistry has been addressed in dental schools of different countries regarding to (1) teaching students at the predoctoral level; (2) advanced training, (3) research.A convenience sample faculty members from a selection high, upper-middle lower-middle income were recruited complete survey. The survey had 5 open-ended main topics, asked about size their elderly population, general information education; number dentistry, methods; (4) training dentistry;...
The long-term efficacy of targeted therapeutics for cancer treatment can be significantly limited by the type therapy and development drug resistance, inter alia. Experimental studies indicate that factors enhancing acquisition resistance in cells include cell heterogeneity, target alteration, inactivation, DNA damage repair, efflux, death inhibition, as well microenvironmental adaptations to therapy, among others. Combination therapies (CCTs) are employed overcome these molecular...
There is a growing need for high throughput diagnostic tools early diagnosis and treatment monitoring of prostate cancer (PCa) in Africa. The role cancer-testis antigens (CTAs) PCa men African descent poorly researched. Hence, we aimed to elucidate the 123 Tumour Associated Antigens (TAAs) using antigen microarray platform blood samples (N = 67) from South PCa, Benign prostatic hyperplasia (BPH) disease control (DC) cohort. Linear (fold-over-cutoff) differential expression quantitation...
The worldwide expanding increment in cancer pervasiveness is disturbing and this disease ranks among the main causes of mortality both developing developed countries. Unfortunately, available treatment options come with serious side effects do not guarantee complete success. Although numerous models have been proposed for development better therapeutic agent, however exact mechanism are still poorly understood. This then calls continued research aimed at new drugs as an alternative or...
Objective The aim of this study is to characterize immunohistochemical profiles lining epithelia nasopalatine duct cyst ( NPC ) as well correlate those findings with their clinicopathological features understand the histopathogenesis . Materials and methods Forty‐one surgical specimens from were examined for clinical expression keratin‐7, 13, MUC ‐1, P 63 by immunohistochemistry, compared radicular RC maxillary sinusitis. Results Nasopalatine was clinically characterized male predominant...
Purpose Improvement in diagnostic accuracy of prostate cancer (PCa) progression using MS‐based methods to analyze biomarkers our African, Caucasian, and Mixed Ancestry patients can advance early detection treatment monitoring. Experimental design proteomic analysis pooled ( N = 36) individual samples 45) PCa, benign prostatic hyperplasia, normal healthy controls, with other uropathies was used identify differences proteomics profile. Samples were analyzed for potential proteome coverage PCa...
Introduction: although histopathological diagnosis remains the gold standard; good clinical impression is potentially a key diagnostic tool in rural resource-limited settings. Thus, concordance between and thus very crucial oral pathology low- middle-income countries (LMICs).
Introduction: oral cancer is a leading cause of deaths among African populations. Lack standard registries and under-reporting has inaccurately depicted its magnitude in Nigeria. Development multi-centre collaborative pathology networks such as the Oral Pathology Research Consortium (AOPRC) facilitates skill expertise exchange fosters robust systematic investigation diseases across Africa.
Targeted proteomics of potential biomarkers is often challenging. Hence, we developed an intermediate workflow to streamline urinary prostate cancer (PCa).Using previously discovered PCa biomarkers; selected proteotypic peptides for targeted validation. Preliminary in silico immunohistochemical and single reaction monitoring (SRM) verification was performed. Successful PTPs were then prevalidated using parallel (PRM) reconfirmed 15 publicly available databases.Stringency-based targetable...
Many studies have investigated the burden of odontogenic tumor (OT) in Nigeria; however, true and prevalence these lesions are not known because based on a center/region.Hence, aim this study is to evaluate OTs Nigeria, using multicenter approach.This 10-year retrospective cross-sectional OT seen eight tertiary health institutions different geographic locations Nigeria.A total 990 cases were included study. The highest was third decade life (n = 274, 27.7%). Most benign 961, 97.1%), with...