A5072210064- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Hippo pathway signaling and YAP/TAZ
- Oral and Maxillofacial Pathology
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- Lymphatic System and Diseases
- Vascular Procedures and Complications
- Medical Imaging Techniques and Applications
- Central Venous Catheters and Hemodialysis
- Prostate Cancer Diagnosis and Treatment
- Cancer and Skin Lesions
- Cell Image Analysis Techniques
- Cell Adhesion Molecules Research
- Intracranial Aneurysms: Treatment and Complications
- dental development and anomalies
- Vascular Malformations Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Genital Health and Disease
- Aortic aneurysm repair treatments
- Angiogenesis and VEGF in Cancer
- Vascular Tumors and Angiosarcomas
Nippon Dental University
2023
Niigata University
2007-2022
Saga University
2022
Fukuoka University
2017-2022
Yale University
2013-2017
National Cancer Centre Japan
2015-2017
VA Connecticut Healthcare System
2017
Showa University
2017
The University of Tokyo
2017
University of Maryland, College Park
2017
Abstract Histopathological classification of gastric and colonic epithelial tumours is one the routine pathological diagnosis tasks for pathologists. Computational pathology techniques based on Artificial intelligence (AI) would be high benefit in easing ever increasing workloads pathologists, especially regions that have shortages access to services. In this study, we trained convolutional neural networks (CNNs) recurrent (RNNs) biopsy histopathology whole-slide images (WSIs) stomach colon....
Abstract Lung cancer is one of the major causes cancer-related deaths in many countries around world, and its histopathological diagnosis crucial for deciding on optimum treatment strategies. Recently, Artificial Intelligence (AI) deep learning models have been widely shown to be useful various medical fields, particularly image pathological diagnoses; however, AI pulmonary lesions that validated large-scale test sets are yet seen. We trained a Convolution Neural Network (CNN) based...
Histopathological diagnosis of pancreatic ductal adenocarcinoma (PDAC) on endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) specimens has become the mainstay preoperative pathological diagnosis. However, EUS-FNB specimens, accurate histopathological evaluation is difficult due to low specimen volume with isolated cancer cells and high contamination blood, inflammatory digestive tract cells. In this study, we performed annotations for training sets by expert pathologists trained...
Liquid-based cytology (LBC) for cervical cancer screening is now more common than the conventional smears, which when digitised from glass slides into whole-slide images (WSIs), opens up possibility of artificial intelligence (AI)-based automated image analysis. Since processes by cytoscreeners and cytopathologists using microscopes limited in terms human resources, it important to develop new computational techniques that can automatically rapidly diagnose a large amount specimens without...
CD44 has been implicated in a diverse array of cell behaviors and range signaling pathway activations under physiological pathophysiological conditions. We have documented role for mediating vascular barrier integrity via regulation PECAM-1 (CD31) expression. now report our findings on the roles modulating proliferation apoptosis microvascular endothelial cells its modulation CD31 VE-cadherin expression Hippo pathway. In this report, we demonstrate persistent increased reduced both effector...
Abstract The differentiation between major histological types of lung cancer, such as adenocarcinoma (ADC), squamous cell carcinoma (SCC), and small-cell cancer (SCLC) is crucial importance for determining optimum treatment. Hematoxylin Eosin (H&E)-stained slides small transbronchial biopsy (TBLB) are one the primary sources making a diagnosis; however, subset cases present challenge pathologists to diagnose from H&E-stained alone, these either require further immunohistochemistry or...
Objective— Arteriovenous fistulae (AVF) remain the optimal conduit for hemodialysis access but continue to demonstrate poor patency and rates of maturation. We hypothesized that CD44, a widely expressed cellular adhesion molecule serves as major receptor extracellular matrix components, promotes wall thickening deposition during AVF Approach Results— were created via needle puncture in wild-type C57BL/6J CD44 knockout mice. mRNA protein expression was increased AVF. mice showed no increase...
The histopathological diagnosis of prostate adenocarcinoma in needle biopsy specimens is pivotal importance for determining optimum cancer treatment. Since diagnosing a large number cases containing 12 core by pathologists using microscope time-consuming manual system and limited terms human resources, it necessary to develop new techniques that can rapidly accurately screen numbers specimens. Computational pathology applications assist detecting classifying from whole-slide images (WSIs)...
Several models of arteriovenous fistula (AVF) have excellent patency and help in understanding the mechanisms venous adaptation to arterial environment. However, these fail exhibit either maturation failure or develop stenoses, both which are critical modes AVF human patients. We used high-resolution Doppler ultrasound serially follow mice with AVFs created by direct 25-gauge needle puncture. By day 21, 75% dilate, thicken, increase flow, i.e., mature, 25% due immediate thrombosis failure....
Purpose The venous limb of arteriovenous fistulae (AVF) adapts to the arterial environment by dilation and wall thickening; however, temporal regulation expression extracellular matrix (ECM) components in maturing AVF has not been well characterized. We used a murine model maturation that recapitulates human determine pattern these ECM components. Methods Aortocaval were created C57BL/6J mice was analyzed on postoperative days 1, 3, 7, 21, 42. A gene microarray analysis performed day 7;...
Signet ring cell carcinoma (SRCC) of the stomach is a rare type cancer with slowly rising incidence. It tends to be more difficult detect by pathologists, mainly due its cellular morphology and diffuse invasion manner, it has poor prognosis when detected at an advanced stage. Computational pathology tools that can assist pathologists in detecting SRCC would massive benefit. In this paper, we trained deep learning models using transfer learning, fully-supervised weakly-supervised predict...
Although the histopathological diagnosis of cutaneous melanocytic lesions is fairly accurate and reliable among experienced surgical pathologists, it not perfect in every case (especially melanoma). Microscopic examination–clinicopathological correlation gold standard for definitive melanoma. Pathologists may encounter diagnostic controversies when melanoma closely mimics Spitz’s nevus or blue nevus, exhibits amelanotic histopathology, situ. It would be beneficial if diagnosing can automated...
Colorectal poorly differentiated adenocarcinoma (ADC) is known to have a poor prognosis as compared with well moderately ADC. The frequency of ADC relatively low (usually less than 5% among colorectal carcinomas). Histopathological diagnosis based on endoscopic biopsy specimens currently the most cost effective method perform part colonoscopic screening in average risk patients, and it an area that could benefit from AI-based tools aid pathologists their clinical workflows. In this study, we...
Background: The intraepithelial deposit of perlecan, a basement membrane‐type heparan sulfate (HS) proteoglycan, has been demonstrated in neoplastic conditions such as salivary gland tumors, odontogenic and oral carcinoma situ . Our aim was to determine whether perlecan turnover enhanced the lining cells keratocystic tumor (KCOT), which had recently renamed from keratocyst because its accumulated evidence neoplasm, possible background for proliferation. Methods: Ten surgical specimens each...
Tsuneki M, Yamazaki Cheng J, Maruyama S, Kobayashi T & Saku (2010) Histopathology 57, 806–813 Combined immunohistochemistry for the differential diagnosis of cystic jaw lesions: its practical use in surgical pathology Aims: Histopathological distinction lesions, including odontogenic tumours, is challenging because their lining epithelia, which are basically stratified squamous resemble each other, especially when they become hyperplastic from inflammatory reaction. The aim this study...
Abstract Mieap, a novel p53-inducible protein, plays key role in maintaining healthy mitochondria various pathophysiological states. Here, we show that Mieap deficiency Apc Min/+ mice is strikingly associated with the malignant progression of murine intestinal tumors. To understand vivo tumorigenesis, generated heterozygous (Apc +/− ) and homozygous −/− mice. Interestingly, genetic background revealed remarkable shortening lifetime compared to because severe anemia. A substantial increase...
Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria. BNIP3 and NIX are critical mediators for the Mieap-regulated control. Mieap suppresses murine intestinal tumor via its control function. To explore role of mitochondria function in colorectal cancer patients, we examined statuses p53, 57 primary tissues. Promoter methylation genes was found 9% 47% cases, respectively, whereas p53 mutation more than 50% tissues lacking promoters,...
Abstract Gastric diffuse-type adenocarcinoma represents a disproportionately high percentage of cases gastric cancers occurring in the young, and its relative incidence seems to be on rise. Usually it affects body stomach, presents shorter duration worse prognosis compared with differentiated (intestinal) type adenocarcinoma. The main difficulty encountered differential diagnosis adenocarcinomas occurs diffuse-type. As cancer cells are often single inconspicuous background desmoplaia...