A5102919155- Gastric Cancer Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Medical Imaging and Pathology Studies
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Cardiac Ischemia and Reperfusion
- Metastasis and carcinoma case studies
- HER2/EGFR in Cancer Research
- Diabetes Treatment and Management
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Screening and Detection
- Robotics and Sensor-Based Localization
- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- Robotic Path Planning Algorithms
- Pharmacy and Medical Practices
- Diet and metabolism studies
- Skin and Cellular Biology Research
- Cardiovascular Function and Risk Factors
- Cancer Cells and Metastasis
- Parathyroid Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Advanced Breast Cancer Therapies
Sapporo Higashi Tokushukai Hospital
2024
Toyohashi University of Technology
2021-2023
BoZo Research Center (Japan)
2023
Okayama Medical Center
2021-2022
National Hospital Organization
2021-2022
Sapporo Kosei General Hospital
2022
National Cancer Center Hospital East
1993-2021
Chiba University
2016-2020
Juntendo University
2020
Nippon Shinyaku (Japan)
2013
Liquid-based cytology (LBC) for cervical cancer screening is now more common than the conventional smears, which when digitised from glass slides into whole-slide images (WSIs), opens up possibility of artificial intelligence (AI)-based automated image analysis. Since processes by cytoscreeners and cytopathologists using microscopes limited in terms human resources, it important to develop new computational techniques that can automatically rapidly diagnose a large amount specimens without...
The mechanism by which FK506 (FK) prevents hepatic injury induced ischemia/reperfusion was studied. Adult Sprague-Dawley rats were subjected to 60-min normothermic liver ischemia. Animals divided into two groups: group I, controls, saline vehicle treatment; II, FK treatment. (1 mg/kg/day, p.o.) given for 4 consecutive days prior inducing In addition a survival study, plasma levels of endotoxin and serum activities tumor necrosis factor-α (TNF) aspartate aminotransferase (AST) assessed in the...
Abstract The role of hepatovenous back-perfusion in maintaining hepatic viability was investigated during inflow occlusion (Pringle manoeuvre) the pig liver. study compared two ischaemia procedures 60 min duration: and plus outflow (vascular exclusion). Each procedure carried out six pigs liver tissue perfusion, energy metabolism, lipid peroxidation 7-day survival were assessed. Although all survived after occlusion, five died vascular exclusion (P < 0·01). Exclusion induced a...
A bromate (BrO3-)-reducing bacterium, designated Rhodococcus sp. strain Br-6, was isolated from soil. The reduced 250 μM completely within 4 days under growth conditions transitioning aerobic to anaerobic conditions, while no reduction observed and conditions. Bromate bromide (Br-) stoichiometrically, acetate required as an electron donor. Interestingly, by Br-6 significantly dependent on both ferric iron a redox dye 2,6-dichloroindophenol (DCIP). Cell free extract of showed...
The use of nivolumab or irinotecan as the third-line treatment for patients with advanced gastric cancer (AGC) remains controversial.
We investigated the effect of clot activators carried over from serum tube on major coagulation tests during phlebotomy. First, blood specimens 30 normal subjects were mixed with small amounts fluid containing activators, and their effects various determined. Only value fibrin monomer complex displayed a remarkable change when thrombin-containing was added to specimens. Subsequently, 100 paired (taken 75 healthy volunteers 25 patients taking warfarin) collected in tubes before after using...
We examined the hepatoprotective effect of a prostaglandin (PG)I2 analogue by analyzing endogenous release prostanoid from pig liver. Fourteen female pigs underwent 1 hr complete hepatic vascular exclusion (HVE); portal and vena caval circulation was actively decompressed. The animals were divided into one two groups (n = 7, each) according to pretreatment with prostacyclin (OP 2507, OP) administered via mesenteric vein branch for 30 min at rate 2 micrograms/kg/min immediately prior HVE....
Abstract This paper presents a case with type 2 diabetes mellitus on very‐low‐carbohydrate diet who developed euglycemic diabetic ketoacidosis (EDKA) 3 days after starting sodium‐glucose cotransporter inhibitors (SGLT2i). When initiating SGLT2i, healthcare providers should confirm the implementation of low‐carbohydrate and provide intensive guidance to prevent EDKA.
症例は70歳の男性。主訴は背部痛と発熱である。前医にて腹部CT施行し急性膵炎の診断にて当院へ紹介となった。急性膵炎の診断で紹介されたが，当院で施行した各種検査にて細菌性肺炎による敗血症と急性腎前性腎不全と診断した。集中治療室で抗菌薬投与，大量輸液にて加療を開始した。入院後比較的安定して経過していたが入院翌日から病状は急激に悪化した。集学的治療を継続したが入院3日目には多臓器不全，播種性血管内凝固症候群の状態となり死亡退院となった。施行した病理解剖，入院時の血液および胸水，喀痰培養全てからStreptococcus pyogenesを検出し原発性腹膜炎を伴う劇症型A群溶血性連鎖球菌感染症と診断した。A群溶血性連鎖球菌による原発性腹膜炎は極めて稀な疾患である。自験例を除く7症例に死亡例はなく，原因不明の腹膜炎もしくは消化管穿孔の術前診断にて腹腔内洗浄・ドレナージ術が施行され，術後の集学的治療を経て救命し得ている。自験例が救命可能であったかの検討を踏まえ報告する。
Subcutaneous insulin resistance syndrome is a rare condition that causes difficulty in glycemic control due to severe subcutaneous injections. We herein present case of 40-year-old woman with type 2 diabetes mellitus who had been diagnosed since the age 29 years, and persistently treated continuous infusion using mixture lispro heparin. The patient was switched from plus heparin ultra-rapid lispro; given it contains treprostinil citrate, expected have similar effects as heparin, shows...
ABSTRACT Background Intensified systemic chemotherapy following minimally invasive surgery for patients with unresectable metastatic colorectal cancer is performed to achieve curative resection and improve quality of life. We report a case initially rectal metastases treated laparoscopic thoracoscopic staged resections after triplet plus bevacizumab. Case A 71‐year‐old man was referred our hospital examine the cause constipation. circumferential adenocarcinoma extramural invasion lateral...
症例は59歳の男性で，主訴は肛門部痛，便秘．CTで骨盤内に12 cmの腫瘤を認め，経皮的針生検にて直腸gastrointestinal stromal tumor（以下，GIST）と診断した．メシル酸イマチニブ（400 mg/日）を開始し，2か月後に腫瘍は7 cmに縮小したが，4か月後に臀部痛が出現し入院となった．入院時直腸診では腫瘍側の圧痛以外に異常はなかった．入院4日目のCTで腫瘍は5 cmに縮小していたが，直腸周囲にガス像を認め，直腸GISTの穿通が疑われた．翌日，陰嚢の腫脹と会陰部の圧痛，さらに鼠径部から腹壁に捻髪音を伴う発赤を認め，Fournier's gangreneと診断し，ただちに壊死組織の除去，切開排膿ドレナージ術を施行した．経過は良好で，術後58日目に退院となった．メシル酸イマチニブ投与中にFournier's gangreneを合併した直腸GIST穿通例を経験した．メシル酸イマチニブによる巨大GISTの治療の際はその劇的な治療効果ゆえに消化管穿孔も考慮する必要がある．
症例は57歳，女性．うつ病にて過食と臥床を繰り返していた．朝食後口腔内に食物を充満させ窒息し，痙攣を起こしているところを発見され，救急搬送された．来院時意識レベルはIII-100（JCS），口腔内容物は既に除去されており，チアノーゼがあるものの自発呼吸を認めた．胸部では湿性ラ音を聴取し，腹部は膨満あるも筋性防御はなかった．胸部X線検査では両肺野に淡い浸潤影と大量の腹腔内遊離ガス像を認めた．誤嚥性肺炎を合併した消化管穿孔と診断し，直ちに手術を施行した．開腹すると胃体上部小彎側に縦走する約5cmの穿孔を認めた．穿孔部に潰瘍や腫瘍等の器質的疾患を認めず，特発性胃破裂と診断し一期的に縫合閉鎖した．自験例は過食による過膨張胃に，嘔吐や痙攣に起因した急激な胃内圧上昇が加わり，小彎側が破裂したものと考えられた．
125I-insulin binding to rat erythrocytes was studied investigate the effect of whole body hyperthermia on insulin receptor. Heat treatment rats at 42°C for 15 min caused a significant decrease (48.7% control) in erythrocytes. Scatchard analysis showed that decreased resulted from number receptors rather than receptor affinity. The no evidence recovery, 2 h and 8 after hyperthermia. Plasma levels remained lower control, up hyperthermia, whereas plasma glucose, which immediately increased...