A5038310819- Particle physics theoretical and experimental studies
- Pulmonary Hypertension Research and Treatments
- Particle Accelerators and Free-Electron Lasers
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Liver Disease Diagnosis and Treatment
- High voltage insulation and dielectric phenomena
- Cardiovascular Function and Risk Factors
- Particle accelerators and beam dynamics
- Metastasis and carcinoma case studies
- Monoclonal and Polyclonal Antibodies Research
- Radiation Detection and Scintillator Technologies
- Acute Myeloid Leukemia Research
- Congenital Heart Disease Studies
- Glycosylation and Glycoproteins Research
- Organ Transplantation Techniques and Outcomes
- Gastric Cancer Management and Outcomes
- Crystallography and Radiation Phenomena
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Pancreatic function and diabetes
- Tracheal and airway disorders
- Transplantation: Methods and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
THK (Japan)
2022-2024
Sapporo Higashi Tokushukai Hospital
2024
Higashihiroshima Medical Center
2024
Hiroshima University
2013-2023
The Graduate University for Advanced Studies, SOKENDAI
2022
Juntendo University Urayasu Hospital
2020-2021
Ishikawa Prefectural Central Hospital
2019-2021
Tenshi Hospital
2009-2020
ORCID
2020
Iwate Prefectural Central Hospital
2009-2019
In order to study whether hyperplasia or hypertrophy of cells is responsible for the thickening airway muscles, 3-D morphometry muscle was performed on resin-embedded semithin serial sections autopsied lungs from 10 asthmatics and five control subjects. There were Type I II asthmatic lungs, as defined in an earlier study, thickened muscles being found only central bronchi distributed over whole tree II. The analysis based “unbiased” obtain numerical density Nv using a “disector, ” spatial...
Hepatocyte growth factor (HGF) is a humoral mediator of epithelial-mesenchymal interactions, acting on variety epithelial cells as mitogen, motogen, and morphogen. Exogenous HGF acts hepatotrophic renotrophic during experimental injury. To investigate whether has pulmotrophic function, human recombinant was administered to C57BL/6 mice with severe lung injury by bleomycin (BLM). Low dose simultaneous continuous administration (50 μ g/mouse/7 d) BLM (100 mg/mouse/7 repressed fibrotic...
Abstract Polymorphic epithelial mucin (MUC1) was detected in myeloma cells and sera of multiple patients. HLA-unrestricted CTL that recognize tumor-associated epitopes on MUC1 has been shown to be induced from breast pancreas cancer To investigate whether such can also patients, an allogeneic mixed leukocyte tumor cell culture performed. PBMCs a patient were stimulated by different carcinoma lines. The cultured proliferated line TN established. exclusively expressed TCR-alpha/beta, CD3, CD8....
The percentile volumes υA, υB and υD of A, B D cells in the islets Langerhans were histometrically estimated pancreases from 59 autopsy cases including maturity- growth-onset diabetics nondiabetics. Volumetry was performed microscopically by point counting method using a square-lattice eyepiece, then total cell VA, VB VD calculated islet volume Vi pancreas separately. measurement disclosed prominent difference between three groups. Namely, it only 0.156 0.388 cm3 growth- maturity-onset...
Clinically, many candidates for islet transplantation are already immunized, which increases their risk of graft rejection. Encapsulation pancreatic islets using the TheraCyte™ device has been shown to protect against allograft rejection in nonimmunized recipients. However, capacity prevent immunized recipients not yet studied. In this study, protective was evaluated an allogeneic rat model. Lewis rats were used as donors, and (control) alloimmunized, diabetic Wistar–Furth (WF) Graft...
The haploid germ cell-specific Tektin-t protein is a member of the Tektin family proteins that form filaments in flagellar, ciliary, and axonemal microtubules. To investigate physiological role Tektin-t, we generated mice with mutation tektin-t gene. homozygous mutant males were infertile, while females fully fertile. Sperm morphology function abnormal, frequent bending sperm flagella marked defects motility. In vitro fertilization assays showed defective spermatozoa able to fertilize eggs....
Troglitazone is a 2,4-thiazolidinedione antidiabetic agent with insulin-sensitizing activities. This had been used efficiently in large number of patients but was withdrawn from the market March 2000 because its association idiosyncratic hepatotoxicity. To address susceptible genetic factors responsible for hepatotoxicity associated this agent, we performed polymorphic analysis by target gene approach troglitazone-treated Japanese type 2 diabetes mellitus.One hundred ten treated troglitazone...
Mucus-hypersecreting tumor of the pancreas appears as dilated ducts and cystic spaces filled with mucus. To determine where such tumors arise how they extend, computer-aided three-dimensional reconstruction was done ductal system. This also used to visualize spatial relationships among epithelial hyperplasia, dysplasia, carcinoma in situ (CIS).Surgically removed pancreases were studied from 12 patients mucus-hypersecreting tumors. The specimens fixed buffered formaldehyde solution 10%,...
High energy photon colliders (γγ,γe) are based on e - linear where high photons produced using Compton scattering of laser light electrons just before the interaction point. This paper is a part Technical Design Report collider TESLA. 1 Physics program, possible parameters and some technical aspects at TESLA discussed.
A novel approach is proposed to demonstrate the two-photon Breit-Wheeler process by using collimated and wide-bandwidth γ-ray pulses driven 10-PW lasers. Theoretical calculations suggest that more than 3.2×10^{8} electron-positron pairs with a divergence angle of 7° can be created per shot, signal-to-noise ratio higher 10^{3}. The positron signal, which roughly 100 times detection limit, measured existing spectrometers. This approach, could e^{-}e^{+} pair creation from two photons, would...
Seven pancreases from nondiabetic autopsy cases were submitted to morphometrical analysis of the islets Langerhans as a preliminary investigation diabetic pancreas. The pancreatic approximately simulated by spheres different sizes randomly dispersed in three-dimensional space; thereon parameters Weibull function assumed for distribution islet radii estimated stereologically chord length measurements on histologic sections taken portions By means topographical comparison number, volume, mean...
A morphometric pilot study was performed on airway smooth muscle in 20 autopsy lungs with no history of chronic obstructive pulmonary disease (COPD) to establish a basis for the systematic analysis behavior muscles bronchial asthma or COPD. total 514 samples cross-sectioned airways were taken from these lungs, covering as uniformly possible whole range segmental bronchi terminal bronchioles. In each airway, perimeter length L epithelial basement membrane and area S mural measured using...
Previous work has clarified that the waving amplitude of a linear motion ball guide (LMBG) can be reduced by optimizing for shape crowning on each end raceways in carriage. Waving table using LMBG becomes 1/100 μm order optimization; it is 1/10 without optimization. Moreover, analysis method considering deformation and misalignment assembly also been developed. In recent years, required 1/1000 order. However, analytically confirmed only configuration optimization does not achieve this...
Osteoclasts are multinucleated cells that resorb bones, and derived from hematopoietic of the monocyte/macrophage lineage. The receptor activator NF-κB ligand (RANKL, also called ODF/TRANCE/OPGL) stimulates both osteoclast differentiation progenitors activation mature osteoclasts. To identify genes responsible for differentiation, we used a molecular indexing technique. Here, report clone one these whose transcription is induced by soluble RANKL (sRANKL) in RAW264.7 mouse macrophage cell...
Computer-assisted three-dimensional (3D) reconstruction of the biliary tree including extrahepatic and intrahepatic parts was performed from surgical or autopsy materials 12 patients with hepatohilar bile duct carcinoma in an effort to visualize three-dimensionally distribution dysplasia. In each case, material a hepatic lobe reduced serial slices 1 mm thick using ham slicer, then tumors, ducts situ, those dysplasia were submitted reconstruction. 3D map reproduced on display, dysplastic zone...
For future cell-based therapies for liver diseases, the shortage of cell sources must be resolved. Immortalized human hepatocytes are expected to among new sources. In addition telomerase activation by introduction reverse transcriptase (hTERT), inactivation p16/RB pathway and/ or p53 E6/E7 papillomavirus type 16 (HPV16) has been shown useful efficient immortalization several types. Here we report HPV16 and hTERT. Human adult were lentivirally transduced with Two immortalized hepatocyte...
There are conflicting reports regarding the occurrence of cardiovascular events after a major earthquake. To understand impact Great East Japan Earthquake on events, we retrospectively examined clinical records prepared by emergency room physicians between 2009 and 2011 (n = 66,244), compared these 2009, 2010. was significant increase in number patients with during 3 week period earthquake 106) that same 72) or 2010 65) (P 0.002). The acute coronary syndrome congestive heart failure March...
Abstract A one‐pot continuous‐flow method for hydrogen (deuterium) generation and subsequent hydrogenation (deuterogenation) was developed using a stainless‐steel (SUS304)‐mediated ball‐milling approach. SUS304, especially zero‐valent Cr Ni as constituents of the mechanochemical processing played crucial roles in development reactions.