A5088472392- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Bone health and treatments
- Digestive system and related health
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Mycobacterium research and diagnosis
- Cardiovascular Disease and Adiposity
- Cancer-related Molecular Pathways
- Sarcoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Liver Disease and Transplantation
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Fatty Acid Research and Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac tumors and thrombi
- Medical Imaging and Pathology Studies
- Animal Virus Infections Studies
- Infectious Diseases and Mycology
- Vaccine Coverage and Hesitancy
- Colorectal Cancer Screening and Detection
Kyorin University
2013-2023
Kyorin University Hospital
2014-2021
Mie University
1998
Kuraray (Japan)
1987
Abstract BACKGROUND. Tyrosine kinase domain (TKD) gene mutations of the epidermal growth factor receptor ( EGFR ) have proven to be clinically significant in nonsmall‐cell lung cancer (NSCLC), particularly adenocarcinoma. However, TKD together with deletion extracellular (EGFRvIII) not been fully investigated NSCLC except for The present study sought gain further insight into significance by focusing on nonadenocarcinoma NSCLC. METHODS. were using direct sequencing and mutation‐specific...
Circulating microRNAs (miRNAs) are promising markers for cancer diagnosis and prognosis. Numerous studies evaluating miRNAs as non‑small cell lung (NSCLC) have been conducted in recent years; however, the majority of candidate proposed via individual were inconsistent no marker early stage NSCLC established. In present study, miR‑145, miR‑20a, miR‑21 miR‑223, which previously reported diagnostic NSCLC, re‑evaluated. The serum levels these quantified 56 patients with I‑IV using TaqMan...
Purpose: We examined the influence of inflammatory cytokine levels on postoperative early recurrence in patients who underwent curative lung cancer surgery. Methods: In 107 pulmonary resections for non-small cell (NSCLC) from November 2007 to June 2008, we measured serum interleukin-6 (IL-6) preoperatively, and day (POD) 0, 1, 2. Between July 2009 August 2009, 1 year after date enrollment last patient, investigated survival status each patient identified a group with recurrence.Results:...
Since the KRAS mutation is not responsible for all metastatic colorectal cancer (mCRC) patients with resistance to anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MoAb) therapy, new predictive and prognostic factors are actively being sought.We retrospectively evaluated efficacy of anti-EGFR MoAb-based therapies in 91 mCRC according KRAS, BRAF, PIK3CA mutational status as well PTEN MET expression.In patient group wild-type presence BRAF or mutations was associated lower...
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In this article, the first isolation of Mycobacterium kyorinense specimens in Brazil is described. M. a recently identified species, with few strains reported only Japan. The Brazilian isolates were initially as celatum by PCR restriction enzyme pattern analysis (PRA) hsp65. However, biochemical tests indicated same profile and distinguished them from branderi. sequencing hsp65, rpoB, 16S rRNA genes allowed accurate identification kyorinense.
Background The aim of this study was to identify the unique molecular characteristics biliary tract cancer (BTC) for development novel molecular-targeted therapies. Materials and Methods We performed mutational analysis KRAS, BRAF, PIK3CA, FBXW7 immunohistochemical EGFR TP53 in 63 Japanese patients with BTC retrospectively evaluated association between clinicopathological features BTC. Results KRAS mutations were identified 9 (14%) patients; no detected within analyzed regions FBXW7....
Abstract Background Liquid‐based cytology (LBC) allows immunohistochemistry (IHC), fluorescence in situ hybridization, and molecular testing to be performed fixed cell materials. We examined the feasibility of subtyping EGFR mutation bronchoscopic samples from patients with lung cancer using blocks (CB) based on LBC fixation (LBC‐CB). Methods included 35 consecutive peripheral nodules who underwent endobronchial ultrasonography a guide sheath our hospital. Thirty these were diagnosed by...
Background Liquid‐based cytology (LBC) samples allow immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and molecular testing of nucleic acids to be performed the remaining fixed cells. The current study aimed examine relationship between gene mutational status cytomorphological features primary lung adenocarcinoma (ADC) using LBC materials. Methods Forty consecutive patients with ADC underwent surgical resection our hospital. Cytological material was obtained by scraping...
The histological classifications of invasive lung adenocarcinoma subtypes are considered to predict patient prognosis after surgical treatment. objectives this study were evaluate cytomorphological characteristics and proliferative activities among the predominant patterns by performing cytomorphometric flow cytometric analyses using liquid-based cytology materials.Cytological samples fixed preservatives from 53 surgically-resected specimens obtained between August 2018 November 2019....
We investigated the effect of clot activators carried over from serum tube on major coagulation tests during phlebotomy. First, blood specimens 30 normal subjects were mixed with small amounts fluid containing activators, and their effects various determined. Only value fibrin monomer complex displayed a remarkable change when thrombin-containing was added to specimens. Subsequently, 100 paired (taken 75 healthy volunteers 25 patients taking warfarin) collected in tubes before after using...