Cleidocranial dysplasia (CCD), an autosomal-dominant human bone disease, is thought to be caused by heterozygous mutations in runt -related gene 2 ( RUNX2)/polyomavirus enhancer binding protein 2α A (PEBP2α A)/core-binding factor A1 (CBFA1) . To understand the mechanism underlying pathogenesis of CCD, we studied a novel mutant RUNX2, CCDα A376 , originally identified CCD patient. The nonsense mutation, which resulted truncated RUNX2 protein, severely impaired transactivation activity. We...

Currently low reducing agent operation of blast furnace has been actively pursued in ironmaking due to the global warming. The precise and reliable control aiming at is required attain smoothly stable operation. It considered that mathematical model on process can play an important role ensure A a powerful tool improve conventional processes design new ironmaking. These tendencies requirements are common every country. Thus, development advanced models like DEM (Discrete Element Method)...

A two dimensional mathematical model is developed describing four phase chemical reactions, motion, and heat transfer in the blast furnace. The phases are gas, lump solid, liquid powder. simultaneously calculates steady state composition, velocity, temperature, volume fraction of all phases. predicted solid compositions plausible, but fines dynamic holdup distribution sensitive to consumption processes raceway. has also been extended include silicon reactions. Compared base calculations,...

A two dimensional mathematical model is developed describing four phase motion and heat transfer in the blast furnace. The phases are gas, lump solid, liquid powder. includes simple representations of major chemical reactions physical structures within It calculates steady state velocity, temperature volume fractions all phases. able to allow for influence behaviour each on that every other phase. In particular, it can predict how one may change response a modification another phase's behaviour.

Recent years various trials to decrease carbon dioxide emission from iron and steelmaking industries have been made. One of these is utilization hydrogen in blast furnace process, this study performed numerical simulation operation with injection through tuyere. The simulations were carried out under the conditions constant bosh gas flow rate, adiabatic flame temperature hot metal temperature. results showed that level stack part was decreased increase ratio. This resulted lowering top...

From the backgrounds of recent trends towards low reducing agent operation large blast furnaces and application diversified charging modes for various burdens, an advanced mathematical model furnace is required. Although conventional models based on continuum have been widely used, these are not sufficient demands. Discrete such as discrete element (DEM) particle method expected to enable precisely simulation discontinuous inhomogeneous phenomena in operating conditions. With models,...

This study tries to design the combustion zone in highly efficient blast furnace for aiming at great reduction of energy consumption and environmental loads by use raceway mathematical model. The model treats strictly discontinuous movement lump coke particles inside around raceway, it considers heat exchange with gas chemical reactions gas. In this study, first, verification is performed. Next, controllability conditions investigated. Finally, top recycling process evaluated terms...

Symbol Pattern Abstract This paper introduces a frequency and timing period acquisition technique for orthogonal division multiplexing (OFDM) systems. The proposed estimates both the pesiod offsets at time by using only one pilot symbol with its suitable assignment. Pseudo noise (PN) sequences are introduced to assign these frequencies of so that range can be widened. Numerical examples given show estimate variances additive white Gaussian (AWGN) multipath fading channels.

The blast furnace process is a multi-phase chemical reactor whose main purpose to reduce iron oxides producing hot metal. In the actual operation several phases simultaneously interact with one another exchanging momentum, mass and energy. this paper three-dimensional multiphase mathematical model of presented. This treats as in which all behave like fluids. Five are treated by model, namely, gas, lump solids (iron ore, sinter, pellets coke), pig iron, molten slag pulverized coal....

HANAMURA, HIROKATSU M.D.; HIGUCHI, YOSHINORI NAKAGAWA, MASASHI IWATA, HISASHI NOGAMI, HIROSHI URIST, MARSHALL R. M.D.Editor(s): SETOGUCHI, YOSHIO M.D. Author Information

Low reducing agent operation of the blast furnace is an essential method for mitigating CO2 emissions in ironmaking. Because coke rate reduced low operation, gas permeability tends to deteriorate. Recently, furnaces with inner volume larger than 5000 m3 have become usual not only Japan, but also other Asian nations. Under these conditions, detailed information on in-furnace phenomena required attain stable operation.In present study, a combination model using discrete element and...

The iron and steelmaking industry has been receiving social pressure to reduce energy consumption environmental load as recent increase in the awareness on resource problems. ironmaking system consumes more than a half of overall input steelwork its improvement is expected countermeasure for such Numerous attempts through improving blast furnace operation have made. This paper analyzes material balances that consists hot stove, coke oven, CDQ, sintering furnace. statuses with natural gas...

Maintaining gas permeability is an important issue to realize low coke rate operation of blast furnace. In present study, the melting behavior iron ore and layer structure in were introduced DEM-CFD model, then behaviors moving bed furnace simulated. Influence shape cohesive zone was investigated, effect slit on flow demonstrated calculation result. Surface area intersection angle between burden layers will determine activity slit.

The ironmaking blast furnace is a counter current chemical reactor whose main purpose to produce hot metal (pig iron) from iron oxides. In the furnace, five phases: gas, lump solids (iron ore, sinter, pellets and coke), liquids molten slag) powders (tuyere injectants: pulverized coal, coke fines or dust coke) interact with one another. order evaluate productivity, energy efficiency transient phenomena occurring in comprehensive two-dimensional mathematical model has been developed. was...

Injection of hydrogen bearing matters into blast furnace has been attracting technical and scientific interests aimed to improve the performance through enhancing reduction. In this study, operations humidified blasting, natural gas waste plastics injections are numerically examined in comparison with all-coke operation by means multi-fluid model. The model evaluations carried out under constant raceway conditions hot metal temperature throughout all tested cases. Since injection bearers...

The multiple injection of carbonaceous materials and oxygen enrichment in the blast furnace has received especial attention recent years due to its possibility considerably decrease coke rate increase productivity. This paper introduces a modeling co-injection pulverized coal natural gas into through tuyere. model treats as multi-phase reactor five phases are treated simultaneously: gas, lump solids (iron ore, sinter, pellets coke), pig iron, molten slag coal. Conservation equations for...