A5084852275- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Immune cells in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal disorders and treatments
- Lymphatic System and Diseases
National Cancer Center Hospital East
2016-2025
Chiba Cancer Center
2010-2024
National Cancer Center
2020-2023
Kurume University Hospital
2022
Japan Clinical Cancer Research Organization
2016
Keiyukai Sapporo Hospital
2013
Saitama Cancer Center
2012
King's College Hospital
2011
Tokai University
2011
Dokkyo Medical University
2010
Preoperative chemoradiotherapy (CRT) and surgical resection are the standard treatment for locally advanced rectal cancer (LARC). Combining immune checkpoint inhibitors with radiation suggests a promising approach enhancing efficacy. We investigated efficacy of CRT followed by nivolumab surgery in patients LARC.In phase I, we feasibility sequentially combined CRT, 5 cycles nivolumab, radical surgery. In II, microsatellite stable (MSS) instability-high (MSI-H) LARC were evaluated.Three I...
Because autonomous proliferating cancer cells are often exposed to hypoxic conditions, there must be an alternative metabolic pathway, such as autophagy, that allows them obtain energy when both oxygen and glucose depleted. We previously reported finding autophagy actually contributes cell survival in colorectal cancers vitro vivo . Pancreatic remains a devastating poorly understood malignancy, hypoxia pancreatic is known increase their malignant potential. In the present study archival...
Objectives: To develop and validate histologic diagnostic criteria for autoimmune pancreatitis (AIP) its types. Methods: Thirteen pathologists participated in this 2-phase study to AIP types 1 2 (phase 1) them 2). A virtual library of 40 resected pancreata with other forms chronic (CP) was constructed. Readers reviewed the slides online filled out a questionnaire histopathologic findings diagnosis. Results: Diagnostic were proposed according results from top 5 reviewers phase 1. The...
Generally, cancer tissue is palpated as a hard mass. However, the elastic nature of not well understood. The aim present study was to evaluate clinical utility measuring modulus (EM) in colorectal tissue. Using tactile sensor, we measured EM 106 surgically resected tissues. Data on were compared with clinicopathological findings, including stromal features represented by Azan staining and α-SMA positive area ratio tumor area. Finally, cDNA microarray profile tumors high findings low EM. A...
It is difficult to detect pancreatic cancer or biliary-tract at an early stage using current diagnostic technology. Utilizing microRNA (miRNA) markers that are stably present in peripheral blood, we aimed identify and cancers patients. With "3D-Gene", a highly sensitive microarray, examined comprehensive miRNA expression profiles 571 serum samples obtained from healthy patients, patients with pancreatic, biliary-tract, other digestive cancers, non-malignant abnormalities the pancreas biliary...
Dexamethasone is a glucocorticoid steroid with anti-inflammatory properties used to treat many diseases, including cancer, in which it helps manage various side effects of chemo-, radio-, and immunotherapies. Here, we investigate the tumor microenvironment (TME)-normalizing dexamethasone metastatic murine breast cancer (BC). normalizes vessels extracellular matrix, thereby reducing interstitial fluid pressure, tissue stiffness, solid stress. In turn, penetration 13 32 nm dextrans, represent...
The molecular mechanisms underlying the serrated pathway of colorectal tumourigenesis, particularly those related to traditional adenomas (TSAs), are still poorly understood. In this study, we analysed genetic alterations in 188 polyps, including hyperplastic sessile adenomas/polyps (SSA/Ps), TSAs, tubular adenomas, and tubulovillous by using targeted next-generation sequencing reverse transcription-PCR. Our analyses showed that most TSAs (71%) contained WNT components. particular,...
Abstract Neuroendocrine neoplasms (NENs) are rare that occur in various organs and present with diverse clinical manifestations. Pathological classification is important the diagnosis of NENs. Treatment strategies must be selected according to status differentiation malignancy by accurately determining whether neoplasm functioning or nonfunctioning, degree disease progression, presence metastasis. The newly revised Clinical Practice Guidelines for Gastroenteropancreatic Neoplasms (GEP-NENs)...
Abstract Nano‐immunotherapy regimens have high potential to improve patient outcomes, as already demonstrated in advanced triple negative breast cancer with nanoparticle albumin‐bound paclitaxel and the immune checkpoint blocker (ICB) atezolizumab. This regimen, however, does not lead cures median survival lasting less than two years. Thus, understanding mechanisms of resistance development strategies enhance nano‐immunotherapy are urgently needed. Here, human tissue it is shown that blood...
Abstract Nano-immunotherapy improves breast cancer outcomes but not all patients respond and none are cured. To improve efficacy, research focuses on drugs that reprogram cancer-associated fibroblasts (CAFs) to therapeutic delivery immunostimulation. These drugs, however, have a narrow window cause adverse effects. Developing strategies increase CAF-reprogramming while limiting effects is urgent. Here, taking advantage of the capabilities tranilast, we developed tranilast-loaded micelles....
Histopathological diagnosis of pancreatic ductal adenocarcinoma (PDAC) on endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) specimens has become the mainstay preoperative pathological diagnosis. However, EUS-FNB specimens, accurate histopathological evaluation is difficult due to low specimen volume with isolated cancer cells and high contamination blood, inflammatory digestive tract cells. In this study, we performed annotations for training sets by expert pathologists trained...
Autoimmune pancreatitis (AIP) is a newly recognized disease. The presence of IgG4 positive plasma cells thought to be diagnostic help. In surgical series chronic cases, we determined the relative frequency AIP before and after 1990, analyzed significance expression examined oligoclonal T or B-cell populations. histopathology 202 specimens removed between 1975 2004 was reviewed 2 groups were distinguished, 1 cases other nonautoimmune (non-AIP CP). intensity infiltration pancreatic tissue by...
CD133 has been reported to be a cancer‐initiating cell marker in colorectal carcinoma. The objective of this study was evaluate the frequency expression cancer, distribution CD133‐positive cancer cells, and their relationship clinicopathological features, including survival. An immunohistochemical examination analysis were performed 189 consecutive patients. seen at luminal surface glands mainly with cribriform features. Expression detected only 29 tumors (15.3%). Of these, 21 (11.1%) showed...
Cholangiocarcinoma is a relatively rare cancer, but its incidence increasing worldwide. Although several risk factors have been suggested, the etiology and pathogenesis of majority cholangiocarcinomas remain unclear. Recently, high early-onset cholangiocarcinoma was reported among workers printing company in Osaka, Japan. These underwent exposure to organic solvents, mainly haloalkanes such as 1,2-dichloropropane (1,2-DCP) and/or dichloromethane. We performed whole-exome analysis on four...
4100 Background: Chemoradiotherapy (CRT) followed by radical surgery (S) is standard therapy for patients (pts) with locally advanced rectal cancer (LARC). Sequential use of an anti-PD-1 antibody after radiation demonstrates synergistic effects in vivo models, and effective pts microsatellite instability-high (MSI-H) metastatic colorectal (mCRC). We studied nivolumab (nivo) S following CRT (50.4 Gy capecitabine 1,650 mg/m 2 ) T 3–4 N any M 0 LARC. Methods: After the quality-assured CRT, 240...
Radiotherapy (RT) combined with immunotherapy is promising; however, the immune response signature in clinical setting after RT remains unclear. Here, by integrative spatial and single-cell analyses using multiplex immunostaining (CODEX), transcriptome (VISIUM), RNA sequencing, we substantiated infiltration of cells into tumors dynamic changes immunostimulatory immunosuppressive gene expression RT. In addition, our comprehensive analysis uncovered time- cell type-dependent alterations...
Background Immune checkpoint inhibitor (ICI) combinations represent an emerging treatment strategies in cancer. However, their efficacy microsatellite stable (MSS) or mismatch repair-proficient (pMMR) colorectal cancer (CRC) is variable. Here, a multiomic characterization was performed to identify predictive biomarkers associated with patient response ICI MSS/pMMR CRC for the further development of combinations. Methods Whole-exome sequencing, RNA and multiplex fluorescence...
This paper proposes a novel high-performance vector control system of an ac motor using low-switching-frequency (2 kHz) pulsewidth-modulation voltage-source inverter with output LC filter. Excellent high-speed response characteristics the filter voltage have been realized deadbeat algorithm. As for experimental results, torque current that is similar to conventional without has obtained. In addition, it confirmed by simulation errors constants within /spl plusmn/10% can be permitted.