A5032598140- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Carcinogens and Genotoxicity Assessment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microtubule and mitosis dynamics
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
- Genomic variations and chromosomal abnormalities
- Lung Cancer Research Studies
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Wnt/β-catenin signaling in development and cancer
- Colorectal Cancer Screening and Detection
- Hedgehog Signaling Pathway Studies
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
Hamamatsu University School of Medicine
2016-2025
Fujita Health University Hospital
2024
Ishikawa Prefectural Central Hospital
2022
Kanazawa Hospital
2022
Center for Rheumatology
2021
Tokushima University
2021
Hamamatsu University
2003-2019
Fox Chase Cancer Center
2012
Kyoto University
2012
Catholic University of Korea
2012
In immune cells, CD73 dephosphorylates and converts extracellular AMP into adenosine, which binds the A2A adenosine receptor (A2AR). Blockade of this interaction, induces an immunosuppressed niche in tumor microenvironment, represents a potential novel treatment strategy. The clinical significance A2AR expression non-small-cell lung cancer (NSCLC), however, has yet to be thoroughly investigated. Here we evaluated protein levels using immunohistochemistry tissue microarrays containing 642...
The molecular mechanisms underlying the serrated pathway of colorectal tumourigenesis, particularly those related to traditional adenomas (TSAs), are still poorly understood. In this study, we analysed genetic alterations in 188 polyps, including hyperplastic sessile adenomas/polyps (SSA/Ps), TSAs, tubular adenomas, and tubulovillous by using targeted next-generation sequencing reverse transcription-PCR. Our analyses showed that most TSAs (71%) contained WNT components. particular,...
The identification of cancer biomarkers is critical for target‐linked therapy. overall level phosphatidylcholine ( PC ) elevated in colorectal CRC ). To investigate which species overexpressed cancer, an imaging mass spectrometry was performed using a panel non‐neoplastic mucosal and tissues. In the present study, we identified novel biomarker, (16:0/16:1), spectrometry. Specifically, levels (16:0/16:1) expression were observed more advanced stage . Our data further showed that specifically...
// Yusuke Inoue 1, 2 , Katsuhiro Yoshimura Kazutaka Mori Nobuya Kurabe 1 Tomoaki Kahyo Hiroki 3 Akikazu Kawase 4 Masayuki Tanahashi 5 Hiroshi Ogawa 6 Naoki Inui 2, 7 Kazuhito Funai Kazuya Shinmura Niwa Takafumi Suda Haruhiko Sugimura Department of Tumor Pathology, Hamamatsu University School Medicine, Hamamatsu, Shizuoka, Japan Second Division, Internal Medical Center, First Surgery, Division Thoracic Respiratory Disease Seirei Mikatahara General Hospital, Clinical Pharmacology and...
The human YTH domain family (YTHDF) proteins are RNA-binding that recognize N6-methyladenosine (m6A), facilitating various biological processes via m6A RNA modification. How these molecules associate with non–small-cell lung cancer (NSCLC) molecular mechanisms remain unclear. protein expression levels of YTHDF1 and YTHDF2 in 603 cases resected NSCLC were evaluated using immunohistochemistry. We analyzed the associations attributes patient characteristics survival. also assessed four subsets...
Gastric cancer frequently occurs in family members with hereditary non-polyposis colorectal (HNPCC) and Li–Fraumeni syndrome (LFS) germline E-cadherin mutations were recently identified a subset of familial gastric cancers. Thus, families an aggregation cancers recruited by reviewing the genealogical trees 3632 patients cancer. The criteria for recruiting such following: at least three relatives should have one them be first degree relative other two; two successive generations affected;...
The erythropoietin‐producing hepatocellular ( EPH ) A2 receptor, tyrosine kinase, is overexpressed and phosphorylated in several types of human tumors has been associated with malignant transformation. A recent report, however, indicated that stimulation the EPHA2 receptor ligand, ephrinA1 (EFNA1), inhibits growth ‐expressing breast cancer. authors examined expression EFNA1 using semiquantitative reverse transcription‐polymerase chain reaction (RT‐PCR) four gastric cancer cell lines 49...
DNA glycosylase, encoded by the hOGG1 gene, repairs 8‐hydroxyguanine (oh 8 Gua), which is an oxidatively damaged mutagenic base. To clarify whether repair activity of protein involved in gastric carcinogenesis, we examined 9 cancer cell lines and 35 primary cancers for mutations genetic polymorphisms gene polymerase chain reaction‐single strand conformation polymorphism analysis. A G‐to‐A transition was detected a line, MKN1. This nucleotide change caused conversion amino acid from Arg to...
Nucleophosmin/B23 is a major multifunctional nucleolar phosphoprotein that plays critical role in ribosome biogenesis and cell proliferation. Arf tumor suppressor binds B23 enhances its sumoylation. However, the biological effects of this event remain unknown. Here we show sumoylated on both Lysine 230 263 residues, but latter one. Mutation K263, not K230, into R abolishes centrosomal residency. Moreover, Rb to wild-type B23, fails interact with K263R. Sumoylation binding Rb. Consequently,...
Background and aims: Chromosomal instability (CIN) is recognised as a hallmark of cancer caused by spindle assembly checkpoint disorder or chromosome mis-segregation during mitosis. Although the recent identification human shugoshin (hSgo1), an important player in proper segregation, has suggested involvement hSgo1 colorectal tumourigenesis, little known about how it involved. The aim this study was to obtain information status cancer. Method results: Among 46 cases, mRNA expression...
DNA adducts are produced both exogenously and endogenously via exposure to various DNA-damaging agents. Two lipid peroxidation (LPO) products, 4-oxo-2(E)-nonenal (4-ONE) 4-oxo-2(E)-hexenal (4-OHE), induce substituted etheno-DNA in cells chemically treated animals, but the adduct levels humans have never been reported. It is important investigate occurrence of 4-ONE- 4-OHE-derived further understand their potential impact on human health. In this study, we conducted adductome analysis several...
DNA adducts are a major cause of mutation and mutation-related diseases, but the simultaneous identification multiple has been challenge for decade. An adductome approach using consecutive liquid chromatography double mass spectrometry after micrococcal nuclease treatment paved way to demonstrations numerous in single experiment is expected contribute comprehensive understanding overall environmental endogenous exposures possible mutagens individuals. In this report, we applied an gastric...
The effects of abnormalities in the DNA glycosylases NEIL1, NEIL2, and NEIL3 on human cancer have not been fully elucidated. In this paper, we found that median somatic total mutation loads single nucleotide exhibited significant inverse correlations with NEIL1 NEIL2 expression levels a positive correlation level using data for 13 types from Cancer Genome Atlas (TCGA) database. A subset reduced expressions elevated expression, such abnormal were also significantly associated cancer. As...
Abstract Small cell lung cancer (SCLC) subtypes, defined by the expression of lineage-specific transcription factors (TFs), are thought to be mutually exclusive, with intra-tumoral heterogeneities. This study investigated mechanism underlying this phenomenon aim identifying a novel vulnerability SCLC. We profiled status ASCL1, NEUROD1, POU2F3, and YAP1 in 151 surgically obtained human SCLC samples. On subtyping, high degree mutual exclusivity was observed between ASCL1 NEUROD1 at cell, but...