A5072320175- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Nutrition and Health in Aging
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Corneal surgery and disorders
- Cancer, Lipids, and Metabolism
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Appendicitis Diagnosis and Management
- Helicobacter pylori-related gastroenterology studies
- Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Glaucoma and retinal disorders
- Neurological Disorders and Treatments
- Colorectal Cancer Screening and Detection
- Gastrointestinal disorders and treatments
- Abdominal vascular conditions and treatments
- Corneal Surgery and Treatments
- Retinal Diseases and Treatments
- Gastrointestinal Tumor Research and Treatment
- Diverticular Disease and Complications
- Intraperitoneal and Appendiceal Malignancies
- Pelvic floor disorders treatments
Koto Hospital
2023
Showa University
2023
Showa University Koto Toyosu Hospital
2023
The University of Tokyo
2004-2022
Tokyo National Hospital
2016-2021
Fukuoka University
2016-2021
Tokyo Yamate Medical Center
2020-2021
National Cancer Center
2020
Topcon (Japan)
2008
Kitano Hospital
2008
The molecular mechanisms underlying the serrated pathway of colorectal tumourigenesis, particularly those related to traditional adenomas (TSAs), are still poorly understood. In this study, we analysed genetic alterations in 188 polyps, including hyperplastic sessile adenomas/polyps (SSA/Ps), TSAs, tubular adenomas, and tubulovillous by using targeted next-generation sequencing reverse transcription-PCR. Our analyses showed that most TSAs (71%) contained WNT components. particular,...
Abstract Background Assessment of preoperative general condition to predict postoperative outcomes is important, particularly in older patients who typically suffer from various comorbidities and exhibit impaired functional status. In addition indices such as Charlson Comorbidity Index (CCI), National Institute on Aging Cancer (NIA/NCI), Adult Evaluation-27 (ACE-27), American Society Anesthesiologists Physical Status classification (ASA-PS), controlling nutritional status (CONUT) score...
Abstract Background This study aimed to evaluate the prognostic impact of nutritional and inflammatory measures (controlling status (CONUT) score, index (PNI), modified Glasgow score (mGPS)) on overall survival (OS) in patients with stage IV colorectal cancer (CRC). Methods Subjects were 996 CRC who referred National Cancer Center Hospital between 2001 2015. We retrospectively investigated correlations OS CONUT PNI, mGPS. Multivariate analyses performed using Cox proportional hazards...
Abstract Background Preoperative and early postoperative serum carcinoembryonic antigen (CEA) levels are known prognostic factors in rectal cancer. Recently, a large‐scale study on colon cancer revealed that “preoperatively elevated postoperatively normalized CEA levels” is not an indicator of poor prognosis. However, whether this hold true patients unknown. This aimed to investigate the significance preoperatively undergoing curative resection. Methods Subjects were consecutive stage I‐III...
The incidence of colorectal cancer in adolescent and young adult patients is increasing. However, survival clinical features patients, especially those with stage IV disease, relative to remain unclear.This retrospective single-institution cohort study was conducted at a tertiary care center. Subjects were 861 consecutive who diagnosed the age 15 74 years referred division surgery or gastrointestinal oncology National Cancer Center Hospital from 1999 2013. Overall (OS) investigated...
For brain metastases from non-specific primary tumors, the most frequently used and validated clinical prognostic assessment tool is Karnofsky performance status (KPS). Given lack of factors colorectal cancer (CRC) other than KPS, this study aimed to identify new factors.This retrospective cohort was conducted at a tertiary care center. Subjects were patients with CRC among all who received initial treatment for National Cancer Center Hospital 1997 2015 (n = 7147). Prognostic...
BACKGROUND: Systemic inflammation contributes to the progression of malignancies. The preoperative lymphocyte-to-C-reactive protein ratio has recently been shown predict survival patients with colorectal cancer who undergo surgery, but its prognostic value remains unclear in unresectable metastatic cancer. OBJECTIVE: This study aimed examine values inflammation-based scores cancer, focusing on ratio. DESIGN: is a retrospective from prospectively collected database. SETTINGS: was conducted at...
The 8th edition of the tumor-node-metastasis (TNM) classification classifies inguinal lymph nodes as regional for anal canal carcinoma but non-regional rectal carcinoma. This difference might reflect different prognosis node metastasis from and However, long-term outcomes or adenocarcinoma are unclear, which we aimed to investigate in this study. study population included 31 consecutive patients with who underwent dissection curative intent at National Cancer Center Hospital 1986 2017....
<h3>Aim:</h3> To compare the results of scanning laser polarimetry (GDx) with variable corneal compensation (VCC) and enhanced (ECC) when applied to myopic glaucomatous eyes. <h3>Methods:</h3> Forty glaucoma eyes moderate myopia (between −3 −6 D) 35 high (−8 D or greater) were enrolled in this study. GDx VCC, ECC standard automated perimetry (SAP) performed. The prevalence an atypical retardation pattern (ARP), typical scan score (TSS) retinal nerve fibre layer (RNFL) thickness compared...
The feasibility of laparoscopic surgery for elderly patients remains unclear, as these usually present with comorbidities. Recently, the controlling nutritional status (CONUT) score has drawn attention an evaluation patients’ general well a predictor survival. We retrospectively analyzed overall survival in 424 aged ≥75 years colon cancer, who underwent curative (laparoscopic (n = 167) or open 257)) between January 2004 and December 2013. To adjust heterogeneity both groups, propensity...
Risk factors for recurrence of rectal prolapse after surgery remain unclear. Delorme's procedure is often selected relatively small-sized prolapse, but there are few reports discussing the association between prolapsed rectum length and procedure. We hypothesized that patients with longer prolapses at a higher risk procedure.The study population comprised who underwent January 2014 December 2019 Tokyo Yamate Medical Center. extracted data on patient age, sex, body mass index, previous...
Intussusception in adults is, especially with ulcerative colitis (UC), rare and only described a few cases. Most adult patients intussusception develop abdominal pain or other symptoms of bowel obstruction. This case describes an 18-year-old male UC who treated 5-aminosalycilicacid underwent annual screening colonoscopies. Two attempts revealed that it was impossible to achieve total surveillance through the colonoscopy because multiple polyps were preventing colonoscope from traversing...
Whether prolonged survival with current chemotherapy using molecular target agents has changed the rate of primary tumor-related complications in patients unresectable stage IV colorectal cancer is unclear.This study aimed to investigate among receiving targeted therapy as compared without agents.This was a retrospective review data from prospectively maintained database.The conducted at high-volume multidisciplinary tertiary center Japan.Subjects were 352 consecutive who received systemic...
Abstract Backgrounds Clinical evidence of the preventive effectiveness medium-class topical corticosteroids for capecitabine-induced hand foot syndrome (HFS) is limited. Although pathogenesis and mechanism HFS are unclear, inflammatory reactions thought to be involved in development. This study aimed evaluate effect (hydrocortisone butyrate 0.1% therapy) patients with colorectal cancer receiving adjuvant chemotherapy capecitabine plus oxaliplatin. Methods a single-center, single-arm, phase 2...
Abstract Background: This study aimed to evaluate the prognostic impact of nutritional and inflammatory measures (controlling status (CONUT) score, index (PNI), modified Glasgow score (mGPS)) on overall survival (OS) in patients with stage IV colorectal cancer (CRC). Methods: Subjects were 996 CRC who referred National Cancer Center Hospital between 2001 2015. We retrospectively investigated correlations OS CONUT PNI, mGPS. Multivariate analyses performed using Cox proportional hazards...
ABSTRACT Background In transitioning from the 7th edition of tumor‐node‐metastasis classification (TNM‐7) to 8th (TNM‐8), colorectal cancer with peritoneal metastasis was newly categorized as M1c. 9th Japanese Classification colorectal, appendiceal, and anal carcinoma (JPC‐9), M1c is further subdivided into M1c1 (without other organ involvement) M1c2 (with involvement). This study aimed compare model fit discriminatory ability M category these three systems, no date has made this comparison....