A5007639221- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Metastasis and carcinoma case studies
- Tracheal and airway disorders
- Spine and Intervertebral Disc Pathology
- Meningioma and schwannoma management
- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- Congenital Diaphragmatic Hernia Studies
- Tumors and Oncological Cases
- Airway Management and Intubation Techniques
- Microtubule and mitosis dynamics
- Intracranial Aneurysms: Treatment and Complications
- Surfactants and Colloidal Systems
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Occupational and environmental lung diseases
- Cancer Mechanisms and Therapy
- Cerebrovascular and Carotid Artery Diseases
Seirei Mikatabara General Hospital
1995-2025
Tokyo Metropolitan Komagome Hospital
2025
University of Miyazaki
2024
Sakurabashi Watanabe Hospital
2023
Kanazawa Medical University
2014-2023
Seirei Hamamatsu General Hospital
2017-2023
Kanazawa University
2002-2020
Ishikawa Prefectural Central Hospital
2018-2020
Gunma University
2015-2020
Nagoya City University
2017-2019
To establish the frequency of IDH1 mutations in glioblastomas at a population level, and to assess whether they allow reliable discrimination between primary (de novo) secondary that progressed from low-grade or anaplastic astrocytoma.We screened population-based study for correlated them with clinical data other genetic alterations.IDH1 were detected 36 407 (8.8%). Glioblastoma patients younger (mean, 47.9 years) than those EGFR amplification (60.9 associated significantly longer survival...
An in vivo study to assess the differentiation status of mesenchymal stem cells (MSCs) transplanted nucleus pulposus degenerative discs a rabbit model.To evaluate fate MSCs and determine whether they are suitable alternative for cell transplantation therapy disc degeneration.Although have been proposed as candidate donor treat intervertebral degeneration, their after has not adequately investigated.Autologous MSCs, labeled with green fluorescent protein, were into mature rabbits. Consecutive...
Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12-15 months. The biological characteristics of this exemplified by prominent proliferation, active invasiveness, rich angiogenesis. This mainly due to highly deregulated signaling pathways tumor. Studies these have greatly increased our understanding biology clinical behavior GBM. An integrated view signal...
Abstract Transplantation of mesenchymal stem cells (MSCs) is effective in decelerating disc degeneration small animals; much remains unknown about this new therapy larger animals or humans. Fas‐ligand (FasL), which only found tissues with isolated immune privilege, expressed IVDs, particularly the nucleus pulposus (NP). Maintaining FasL level important for IVD function. This study evaluated whether MSC transplantation has an effect on suppression and preservation privilege a canine model...
Degeneration of the lumbar intervertebral discs is irreversible, with no treatment currently available. Building upon experimental studies that demonstrated importance nucleus pulposus (NP) in preserving disc structure, we reinsertion NP cells slowed further degeneration and direct cell-to-cell contact co-culture mesenchymal stromal (MSCs) significantly upregulated viability basic pre-clinical vitro vivo using animal models human cells. Here, report a 3-year result prospective clinical...
The human YTH domain family (YTHDF) proteins are RNA-binding that recognize N6-methyladenosine (m6A), facilitating various biological processes via m6A RNA modification. How these molecules associate with non–small-cell lung cancer (NSCLC) molecular mechanisms remain unclear. protein expression levels of YTHDF1 and YTHDF2 in 603 cases resected NSCLC were evaluated using immunohistochemistry. We analyzed the associations attributes patient characteristics survival. also assessed four subsets...
Abstract Activated nucleus pulposus (NP) cells can be reinserted into the disc to inhibit intervertebral degeneration. Experimental studies in animals showed that using a coculture system with direct cell‐to‐cell contact mesenchymal stem (MSCs) significantly upregulated biological activity of NP cells. The purpose this study is determine whether activation by autologous MSCs applicable human vitro. Human tissue was obtained from surgical specimens and bone marrow 10 subjects. Six‐well...
We demonstrate the potential of Lithium titanate (LiTiO) and amorphous titanium oxide (a-TiOx) thin films synthesized from diisopropoxide bis acetylacetonate C16H28O6Ti [Ti(acac)2(OiPr)2] using atmospheric-pressure mist chemical vapor deposition method as negative electrode solid electrolyte for anode-free lithium-ion battery (LIB). LTO Ti(acac)2(OiPr)2 LiNO3 at 500 ℃ act a in LIB. In a-TiOx 200-300 ℃, Li-ion permeability improved with charge/discharge cycles acts electrolyte. The high...
Postoperative recurrence is a significant problem in patients with early-stage non-small cell lung cancer (NSCLC), rates of 35% for stage IB and 50% IIA. This study aimed to evaluate the efficacy tegafur-uracil (UFT) as an adjuvant therapy NSCLC poor prognostic factors. A retrospective analysis was conducted 330 IB/IIA who underwent resection between 2000 2019. Patients were divided into two groups based on presence factors (vascular, lymphatic, or pleural invasion high pathological grade)....
Updating and evaluating facility-based guidance in cancer centers for managing healthcare personnel (HCP) with close contact individuals coronavirus disease 2019 (COVID-19) is challenging because these settings are typically excluded from general guidance, practical data on this population limited. This study aimed to describe whether apparent outbreaks occurred under the updated protocol real-world setting of a center. From July 2022 January 2023, 402 HCP who had an individual COVID-19 were...
Abstract Small cell lung cancer (SCLC) subtypes, defined by the expression of lineage-specific transcription factors (TFs), are thought to be mutually exclusive, with intra-tumoral heterogeneities. This study investigated mechanism underlying this phenomenon aim identifying a novel vulnerability SCLC. We profiled status ASCL1, NEUROD1, POU2F3, and YAP1 in 151 surgically obtained human SCLC samples. On subtyping, high degree mutual exclusivity was observed between ASCL1 NEUROD1 at cell, but...
We describe our technique for endobronchial occlusion of bronchopleural fistula (BPF) with metallic coils and glue through a fiber-optic bronchoscope under local anesthesia. After anchoring the vascular embolization at bronchus, cyanoacrylate was sprayed. The sprayed obliterates gaps between stabilizes them. This procedure successfully occluded bronchus except in one post-pneumonectomy case large fistula. method may be therapeutic options BPF, especially patients high risk curative surgery general