A5068495547- Photonic and Optical Devices
- Optical Network Technologies
- Semiconductor Lasers and Optical Devices
- Advanced Photonic Communication Systems
- Advanced Optical Network Technologies
- Acoustic Wave Resonator Technologies
- Advanced Fiber Optic Sensors
- Chronic Lymphocytic Leukemia Research
- Advanced Chemical Sensor Technologies
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Spectroscopy and Laser Applications
- Photonic Crystal and Fiber Optics
- Histiocytic Disorders and Treatments
- Immune Cell Function and Interaction
- Advanced Fiber Laser Technologies
- Analytical Chemistry and Sensors
- Liquid Crystal Research Advancements
- Virus-based gene therapy research
- Sarcoma Diagnosis and Treatment
- Chemotherapy-related skin toxicity
- Lung Cancer Treatments and Mutations
- High voltage insulation and dielectric phenomena
- Neuroblastoma Research and Treatments
- Gas Sensing Nanomaterials and Sensors
Kumamoto University
2003-2025
Kanazawa University
2016-2024
Kanazawa University Hospital
2020-2024
Uwajima City Hospital
2024
Japanese Red Cross Society, Japan
2017-2021
NTT (Japan)
1993-2009
Toppan (Japan)
2007-2009
Japan Advanced Institute of Science and Technology
2005-2006
NLT Technologies (Japan)
2005
Center for Agricultural Resources Research
2002
Non-alcoholic fatty liver disease (NAFLD) represents one of the most common causes chronic worldwide and is characterized by inflammation fibrosis leading to cirrhosis increased risk cancer in a proportion patients. Effective anti-fibrotic agents have yet be approved for treatment NAFLD. The present study aimed evaluate efficacy dipeptidyl peptidase 4 inhibitors (DPP4-I) prevention NAFLD progression patients with type 2 diabetes. was single arm, multi-centre, non-randomised diagnosed...
Abstract Tight junctions (TJs) between adjacent Sertoli cells are believed to form immunological barriers that protect spermatogenic expressing autoantigens from autoimmune responses. However, there is no direct evidence cell TJs (SCTJs) do indeed barriers. Here, we analyzed male mice lacking claudin-11 ( Cldn11 ), which encodes a SCTJ component, and found autoantibodies against antigens of spermatocytes/spermatids in their sera. Defective spermatogenesis -deficient was not restored on...
The design and fabrication of a Ti:LiNbO/sub 3/ optical modulator employing ridge structure with shielding plane are described. offers relatively low microwave propagation loss large interaction between the wave under condition 50 Omega characteristic impedance system, resulting in modulation bandwidth driving voltage. As result, 3-dB 40 GHz voltage 3.6 V is achieved at 1.5 mu m.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
This paper describes novel coplanar waveguide (CPW) electrode and asymmetric strip line (A-CPS) structures, introducing ridged LiNbO/sub 3/ substrates thicker electrodes, for ultra-broad-band optical modulators. The structures are designed here with quasistatic analysis using the finite-element method. Ridged-structures CPW A-CPS electrodes shown to be able reduce driving-voltage below that of conventional planar-type suitable modulation exceeding 100 GHz driving voltage far less than 4 V...
A quadrature-phase-shift-keying optical homodyne detection experiment was conducted at a bit rate of 8 Gb/s. External-cavity laser diodes and single-body QPSK phase modulator were used. The carrier recovered by decision-directed phase-locked loop. first reported measurement bit-error-rate performance is given. receiver sensitivity -27.8 dBm achieved.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A novel method of classifying remote image through a multimode optical fiber by using neural networks is proposed and experimentally tested. network used to recognize the original from pattern transmitted an fiber.
An inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm characterized by the proliferation of myofibroblasts and cell infiltration. Although radical resection only established treatment strategy for IMT, it can cause functional disorders when vital organs are affected. We describe case pediatric IMT bladder with FN1-ALK (fibronectin 1-anaplastic lymphoma kinase) fusion. Radical might lead to urinary disturbance due large size at diagnosis. However, was successfully treated...
A rearrangeable 128*128-channel optical switch based on a multistage network configuration is demonstrated. The properties of components required for achieving up to 1000*1000-channel switches are discussed, taking into account the diffraction limit and liquid crystal light modulator (LCLM) crosstalk. An examination insertion loss crosstalk reveals an average 7.9 -21.2 dB, respectively, worst-case 11.0 -12.8 respectively. Such low-loss low-crosstalk indicate that proposed structure suitable...
The development of hematopoietic stem cell (HSCs) gene therapy for DNA repair disorders, such as Fanconi anemia and Bloom syndrome, is challenging because the induction HSCs apoptosis by cytokine stimulation. Although Baboon envelope pseudotyped lentiviral vector (BaEV-Rless-LV) has been reported a non-stimulatory transfer tool, virus titer BaEV-Rless-LV too low use in clinical applications. Transfected 293 T cells with helper plasmids, including BaEV-Rless plasmid, showed morphological...
A prototype multiprocessor system using three-dimensional board-to-board free-space optical interconnects is constructed for the first time to our knowledge. In system, 64 processing units form a mesh processor network with help of bidirectional interconnects. theoretical analysis shows that freespace effectively solve common interconnection problems such as wiring congestion, signal delay, and clock skew. The COSINE-III, confirmed work well system. also shown be easy extend larger more flexible
A novel variable optical delay circuit that employs an loop and wavelength converters for use in buffer is reported. The time controlled by varying the initial λinitial of signal. This capable regenerating signals, handling variable-length packets, reducing volume buffer.
Hydrogen leak detection sensors must have high sensitivity and a short response time of 1 s or less. A ball surface-acoustic-wave (SAW) hydrogen sensor has can detect in very wide concentration range 10 ppm to 100%. Moreover, fast be expected because the thin sensitive film used. In this study, we developed digital quadrature detector (DQD) measure responses less than s, phases ms intervals with excellent sensitivity. We evaluated SAW where signal was averaged 256 times 0.256 using DQD. As...
It has been suspected that embryos stored in liquid nitrogen tanks may become contaminated with murine pathogens, if some pathogens had introduced to the accidentally. To examine this, we tubes containing mouse hepatitis virus (MHV) or Pasteurella pneumotropica and examined whether progeny mice derived from were not. After storing for 6 months 1 year frozen thawed implanted into oviducts of pseudopregnant female mice, bred vinyl isolators. We could not detect serum antibodies MHV isolate...
We describe a field trial of wavelength routing full-mesh wavelength-division-multiplexing (WDM) (AWG-STAR) network for citywide local administration in Japan. An AWG router and five WDM nodes were connected to the existing fiber downtown area city Chitose, Hokkaido. A 5 /spl times/ was overlaid on Chitose intranet. video-on-demand system based Gigabit Ethernet links, high-definition serial digital interface signals, synchronous hierarchy signals STM-16 links are transmitted routed...
Targeted therapies such as ALK inhibitors show dramatic responses in various cancers; however, long-term administration can be associated with acquired drug resistance. Crizotinib is the first inhibitor reported salvage therapy for refractory anaplastic lymphoma kinase-positive large cell (ALK+ALCL). It has been to have high complete response (CR) rates (approximately 80%) paediatric patients relapsed/refractory ALK+ALCL[1]. However, crizotinib resistance a cause of several mutations,...
For the safety and security of a society, ubiquitous multiple-gas sensors are required. The gas chromatograph (GC) based on separation gases according to elution time is frequently used for sensing, but it not portable. In this situation, we have developed ball surface acoustic wave (SAW) sensor, where SAW sphere with specific width naturally collimated makes multiple roundtrips without diffusing by diffraction. study, in order develop portable GC, column using...
The authors develop and demonstrate an optical packet synchronizer. Synchronization with a time resolution of 16 ns is achieved by selecting one 64 paths, each different length, using wavelength space switching based on tunable distributed Bragg reflector laser diode eight semiconductor amplifier gates per channel. Asynchronous signals are successfully aligned in series common slots.
Travelling-wave type LiNbO3 (LN) optical modulator structures employing thicker coplanar waveguide (CPW) electrodes are presented, for achieving a lower driving-voltage and broader bandwidth characteristic with an impedance velocity match condition. To design high-performance device-structure, figure of merit p is introduced travelling-wave modulators, which can make excellent smaller value p. Microwave characteristics the modulators ridged LN-substrate theoretically compared to those...
The authors propose two novel designs of a waveguide photodiode for access networks; one is planar conjunction with impurity diffusion to simplify the fabrication process and other an intentionally p-type doped photoabsoption layer lower operating voltage. Without degrading efficiency, fabricated device has bandwidth 500 MHz at 1 V 250 even 0 V.
Familial amyloidotic polyneuropathy (FAP) is a hereditary disease characterized by the systemic accumulation of amyloid fibrils. A mutant transthyretin (TTR) gene mainly responsible for disease. However, variable age onset and low penetrance might be due to environmental factors, one which intestinal flora. Three types flora were introduced into transgenic (Tg) mouse FAP model, 6.0-hMet30. The CV1 CV2 group mice transferred with from two different facilities housed under conventional...