A5075622734- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Hormonal Regulation and Hypertension
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Angiogenesis and VEGF in Cancer
- Renin-Angiotensin System Studies
- Pancreatitis Pathology and Treatment
- Hepatitis C virus research
- Liver Diseases and Immunity
- Cancer Mechanisms and Therapy
- Diet, Metabolism, and Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis B Virus Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Aortic Disease and Treatment Approaches
- Fibroblast Growth Factor Research
- Helicobacter pylori-related gastroenterology studies
- Drug Transport and Resistance Mechanisms
- Alcohol Consumption and Health Effects
- Metabolomics and Mass Spectrometry Studies
- Peptidase Inhibition and Analysis
Nara Medical University
2014-2025
Nara Medical University Hospital
2009-2021
Murata (United States)
2021
Nara University
2021
Weatherford College
2021
Takeda (United States)
2021
Suzuki (Japan)
2021
Kumamoto University Hospital
2018
Saga University
2015-2017
Creative Research Enterprises (United States)
2016
The renin-angiotensin system (RAS) is frequently activated in patients with chronic liver diseases. Angiotensin-II (AT-II) has been suggested to play an important role fibrogenesis. It induces hepatic stellate cell (HSC) proliferation and up-regulates the transforming growth factor beta(1) (TGF-beta(1)) expression via AT-II type 1 receptor (AT(1)-R) vitro. aim of present study was examine vivo effect candesartan (CA), a clinically used AT(1)-R blocker (ARB), perindopril (PE),...
Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been shown to be increased in liver fibrosis development both murine experimental models and human samples. However, the direct role TIMP-1 during not defined. To address this issue, we developed transgenic mice overexpressing (hTIMP-1) under control albumin promoter/ enhancer. A model CCl(4)-induced hepatic was used assess extent (TIMP-Tg) hybrid (Cont) mice. Without any treatment, overexpression itself did induce fibrosis. There were no...
It has been suggested that the tissue inhibitor of metalloproteinases-1 (TIMP-1) is involved in spontaneous resolution liver fibrosis. The aim this study was to investigate whether TIMP-1 altered fibrosis conjunction with matrix metalloproteinases (MMP) inhibition and hepatic stellate cell (HSC) activation. livers liver-targeted transgenic (TIMP-Tg) control hybrid (Cont) mice were harvested at 0, 3, 7, 28 days following recovery from CCl 4 -induced extent resolution, MMP expression,...
Background: Endotoxin plays an important role in the initiation and aggravation of alcoholic liver disease. In this study, we evaluated plasma endotoxin levels serum concentrations cytokines lipopolysaccharide binding protein (LBP) during acute recovery phase patients with hepatitis; also explored prognostic factors associated a fatal outcome. Methods: Fourteen patients, consisting eight hepatitis (AH), five cirrhotics superimposed AH (LC+AH), one patient severe (SAH), were studied. Among...
Angiogenesis is now recognized as a crucial process in tumor development, including hepatocellular carcinoma (HCC). Since HCC known hypervascular tumor, anti-angiogenesis promising approach to inhibit the development. Trientine dihydrochloride (trientine) used clinical practice an alternative copper (Cu)-chelating agent for patients with Wilson's disease of penicillamine intolerance. In our study, we examined effect Cu-chelating agents on development and angiogenesis murine xenograft model....
The growth of any solid tumor depends on angiogenesis. Among the known angiogenic factors, basic fibroblast factor (bFGF) and vascular endothelial (VEGF), are potent representative factors involved in development. It has been reported that bFGF VEGF showed a synergistic effect both vitro vivo However, interaction these development angiogenesis, including hepatocellular carcinoma (HCC), not yet elucidated. In this study, we examined combined overexpression by means combination retroviral...
Nonalcoholic steatohepatitis (NASH) may cause fibrosis, cirrhosis, and hepatocellular carcinoma (HCC); however, the exact mechanism of disease progression is not fully understood. Angiogenesis has been shown to play an important role in chronic liver disease. The aim this study was elucidate angiogenesis development fibrosis hepatocarcinogenesis NASH. Zucker rats, which naturally develop leptin receptor mutations, their lean littermate rats were fed a choline-deficient, amino acid-defined...
It is widely recognized that activated hepatic stellate cells (HSC) play a pivotal role in development of liver fibrosis. A platelet-derived growth factor (PDGF) the most potent mitogen for HSC. The aim this study was to examine effect imatinib mesylate (STI-571, Gleevec), clinically used PDGF receptor (PDGFR) tyrosine kinase inhibitor, on experimental rat model pig serum-induced fibrosis assess daily oral administration STI-571 indexes markedly attenuated and hydroxyproline serum markers....
Previous clinical studies have demonstrated that endotoxin/toll‑like receptor 4 (TLR4) signaling is critical in the inflammatory pathways associated with non‑alcoholic steatohepatitis (NASH). In human and animal studies, NASH was portal lipopolysaccharide (LPS) plasma LPS level hypothesized to be small intestinal bacterial overgrowth, change composition of microbiota increased permeability. The aim present study investigate roles endogenous endotoxin TLR4 pathogenesis NASH. effects...
Abstract: To examine whether cancer cell dissemination results from incisional biopsy, we tried to detect squamous carcinoma (SCC) cells in peripheral blood before and after biopsy by means of cytokeratin 19 (CK19) reverse‐transcriptase polymerase chain reaction (RT‐PCR). The study population consisted 20 patients with oral SCC; 10 were given biopsies followed radical excision (the group), the remaining treated excisional alone group). Ten non‐oral benign lesions served as controls. Five‐ml...
Abstract The tissue inhibitor of matrix metalloproteinases‐1 (TIMP‐1) has been recognized as a multifunctional protein. role TIMPs in cancer remains the subject conflicting reports with an antitumor activity or tumor growth stimulation by several mechanisms. aim our study is to investigate effect ectopic TIMP‐1 overexpression on primary transplanted growth. We employed transgenic mice overexpressing human (hTIMP‐1) liver under control albumin promoter/enhancer (TIMP‐Tg‐mice) and producing...
It has been shown that angiogenesis plays an important role not only in tumor growth, but also early carcinogenesis. The expression of a potent angiogenic factor, vascular endothelial growth factor (VEGF), increased during the stage In this study, effects neutralizing monoclonal antibodies R1 mAb and R2 VEGF receptors Flt-1 (VEGFR-1) KDR/Flk-1 (VEGFR-2), respectively, on murine hepatocarcinogenesis induced by diethylnitrosamine (DEN) were examined. spontaneous lung metastasis from...
Apart from simple steatosis, the non-alcoholic steatohepatitis (NASH) can progress into liver fibrosis and cirrhosis. To date, however, no widely accepted therapeutic modalities have been established against NASH in clinical practice. find out promising new agents, it is important to employ an appropriate experimental model of NASH, such as association with insulin resistance. In current study, we found that losartan, a clinically used angiotensin-II type 1 receptor blocker, significantly...
Angiotensin II type I receptor blocker and iron chelator reportedly exert suppressive effects on nonalcoholic steatohepatitis (NASH) progression, including liver fibrosis hepatocarcinogenesis. The aim of this study was to elucidate the combined effect losartan (LOS), an angiotensin blocker, deferasirox (DSX), a newly developed oral chelator, progression NASH in rats. To induce NASH, F344 rats were fed choline-deficient l-amino acid-defined diet for 12 wk, LOS DSX at clinically comparable low...
The innate immune system, including toll-like receptor-4 (TLR4) signaling cascade and angiotensin-II (AT-II) play important roles in the progression of liver fibrosis development; cross talk between TLR4 AT-II has not been elucidated yet. aim current study was to elucidate effect type 1 receptor blocker (ARB), on development, especially conjunction with interaction rat model non-alcoholic steatohepatitis.Fischer 344 rats were fed a choline-deficient, L-amino-acid-defined diet for 8 weeks...
Non-alcoholic fatty liver disease (NAFLD) represents one of the most common causes chronic worldwide and is characterized by inflammation fibrosis leading to cirrhosis increased risk cancer in a proportion patients. Effective anti-fibrotic agents have yet be approved for treatment NAFLD. The present study aimed evaluate efficacy dipeptidyl peptidase 4 inhibitors (DPP4-I) prevention NAFLD progression patients with type 2 diabetes. was single arm, multi-centre, non-randomised diagnosed...
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Radiofrequency ablation (RFA) can be utilized in elderly patients and those with cirrhosis reduced functional liver reserve as it less invasive. The arfa RFA system first to offer a linear mode. However, differences performance between existing (nonlinear) modes remain unknown. Aim This retrospective observational study compared (linear group) nonlinear (nonlinear HCC. Methods Data 425 three HCC...