A5037397895- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Dental Radiography and Imaging
- Head and Neck Surgical Oncology
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
- Tumors and Oncological Cases
- Oral Health Pathology and Treatment
- Temporomandibular Joint Disorders
- Peptidase Inhibition and Analysis
- Orthodontics and Dentofacial Orthopedics
- Oral and gingival health research
- Facial Nerve Paralysis Treatment and Research
- Protease and Inhibitor Mechanisms
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Oral health in cancer treatment
- Trigeminal Neuralgia and Treatments
- Facial Trauma and Fracture Management
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Bone health and treatments
Kurume University Medical Center
2016-2025
Kurume University
2011-2022
St. George's University
2019-2020
Seattle University
2017-2019
Tulane University
2019
ISI Foundation
2017-2019
Japanese Urological Association
2019
Nippon Dental University Hospital
2019
Qi2
2019
Kanagawa Dental University
2019
Loss of mitochondrial membrane potential (ΔΨm) triggers dramatic structural changes in mitochondria from a tubular to globular shape, referred as fragmentation; the resulting are called swelled or ring/doughnut mitochondria. We evaluated early period during ΔΨm loss-induced transformation after carbonyl cyanide m-chlorophenyl hydrazine (CCCP) administration using newly developed correlative microscopic method combined with fluorescence live imaging and volume electron microscopy. found that...
Dengue virus type 2, a member of the family Flaviviridae, encodes single polyprotein precursor consisting 3391 amino acid residues that is processed to at least 10 mature proteins by host and viral proteases. The NS3 protein contains domain commonly found in cellular serine proteinases cooperation with NS2B involved processing. In addition, NS5 contain conserved motifs several RNA helicases RNA-dependent polymerases, respectively. Both enzymatic activities have been suggested be replication....
Matrix metalloproteinases (MMP) are a gene family of zinc enzymes capable degrading almost all the extracellular matrix macromolecules in vivo. Their enzymic activities believed to be responsible for tumor invasion and metastasis.In this study, using peroxidase-antiperoxidase method, monospecific antisera against MMP-1 (tissue collagenase), MMP-2 (type IV collagenase/72-kilodalton [KD] gelatinase), MMP-3 (stromelysin) were applied 29 squamous cell carcinomas normal epithelium esophagus...
To investigate the effect of matrix-degrading enzymes on malignant potential oral squamous cell carcinoma, expression matrix metalloproteinase-2 (MMP-2/72-kD gelatinase/type IV collagenase) in 46 patients who had neck surgery for cancer was studied immunohistochemically. In 20 26 (76.9%) with lymph node metastases, proMMP-2 strongly expressed, whereas production tissue detected only 5 (25%) no metastases. specimens, expressed a diffuse invasive mode and advancing front cancer. Because MMP-2...
Recent studies investigating accessory mental foramina using developments in diagnostic imaging have primarily defined the morphology of foramina; however, few described structures passing through them. Additional clinical knowledge is therefore required for preoperative diagnosis prior to surgery, including implant, periodontal and periapical surgery. In this study, we investigated associated nerves arteries donated cadaveric mandibles anatomical radiological observation methods. We...
Abstract: To examine whether cancer cell dissemination results from incisional biopsy, we tried to detect squamous carcinoma (SCC) cells in peripheral blood before and after biopsy by means of cytokeratin 19 (CK19) reverse‐transcriptase polymerase chain reaction (RT‐PCR). The study population consisted 20 patients with oral SCC; 10 were given biopsies followed radical excision (the group), the remaining treated excisional alone group). Ten non‐oral benign lesions served as controls. Five‐ml...
Abstract Anatomical details regarding venous drainage of the head and neck are an important matter for surgeons to avoid unnecessary complications such as hemorrhage. This report describes a case large ring around mandibular condyle found in cadaver. The left maxillofacial region latex-injected embalmed male cadaver (82 years age at death) was dissected. two maxillary veins ran lateral capsule superior notch coursed posteroinferiorly merge, one trunk formed posterior border ramus. It then...
Cancer stem cells (CSCs) or cancer cell-like (CSC-LCs) are a minority population of that relate to tumor progression, metastasis and drug resistance. To identify CSC-LCs in oral squamous cell carcinoma (OSCC), we used two OSCC lines, SAS OSC20, surface markers, CD44v3 CD24. In addition, examined CD24 expression immunohistochemically evaluated the relationship between clinicopathological parameters 50 tissues. CD44v3+/CD24- showed higher sphere forming ability than other fractions, i.e.,...
Abstract Previous investigators have reported that transplanted demineralised dentin matrix (DDM) influences bone formation in vivo . However, the specific mechanism of how dentinal tubules contribute to has not been determined with regard DDM transplantation therapy. In this study, we ultrastructurally investigated contacted surrounding newly formed using a scanning electron microscopy (SEM) three-dimensional reconstruction method is based on focused ion beam slicing and SEM (FIB/SEM). A...
To assess tissue characterization relating with neck metastasis of invasive tongue cancer, we investigate the usefulness intra-oral ultrasonography (US).The patients squamous cell carcinoma (n = 110) were preoperatively evaluated US. The US images compared histological sections. and ultrasonographic parameters for their correlation metastasis.High-quality ultrasonic obtained, all lesions over 1 mm thickness by histology detected. There was a significant (P < 0.0001) between measurements...
Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive human cancers, and novel treatment modalities are required. We investigated therapeutic potential tumor necrosis factor–related apoptosis-inducing ligand (TRAIL/Apo2L) in combination with proteasome inhibitor bortezomib (Velcade) on ESCC lines. Bortezomib enhanced susceptibility to TRAIL 12 15 lines tested, although showed low sensitivity as a single agent. The enhancement TRAIL-induced apoptosis by was caspase...
Abstract 4′,5,7‐Trihydroxy‐3′,5′‐dimethoxyflavone (Tricin), a naturally occurring flavone, has anti‐inflammatory potential and exhibits diverse biological activities including antigrowth activity in several human cancer cell lines chemopreventive effects the gastrointestinal tract of mice. The present study aimed to investigate actions tricin on hepatic stellate cells (HSCs) vitro, exploring its as treatment liver fibrosis, since HSC proliferation is closely related progression fibrogenesis...
Abstract The accurate comprehension of normal tissue provides essential data to analyse abnormalities such as disease and regenerative processes. In addition, understanding the proper structure target its microenvironment may facilitate successful novel treatment strategies. Many studies have examined nature periodontal ligaments (PDLs); however, three-dimensional (3D) cells in PDLs remains poorly understood. this study, we used focused ion beam/scanning electron microscope tomography...