A5037500648- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Facial Trauma and Fracture Management
- Bone health and treatments
- Bone Tumor Diagnosis and Treatments
- Reconstructive Surgery and Microvascular Techniques
- ATP Synthase and ATPases Research
- Cleft Lip and Palate Research
- Pain Mechanisms and Treatments
- Oral and gingival health research
- Periodontal Regeneration and Treatments
- Connective Tissue Growth Factor Research
- Dysphagia Assessment and Management
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Cancer, Stress, Anesthesia, and Immune Response
- Peptidase Inhibition and Analysis
- Oral health in cancer treatment
- Ion channel regulation and function
- Cell Adhesion Molecules Research
- Pulmonary Hypertension Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Ear and Head Tumors
Kagoshima University
2024-2025
Shimane University
2020-2024
Okayama University
2013-2022
University of Shimane
2021
Indiana University – Purdue University Indianapolis
2015-2020
Indiana University School of Medicine
2015-2020
Pharmaceutical Biotechnology (Czechia)
2020
Indiana University
2016
Kindai University
2011
Kawasaki Medical School
2010
Multiple myeloma patients experience severe bone pain (MMBP) that is undertreated and poorly understood. In this study, we studied MMBP in an intratibial mouse xenograft model employs JJN3 human multiple cells. model, mice develop associated with increased sprouting of calcitonin gene-related peptide-positive (CGRP+) sensory nerves dorsal root ganglia (DRG) upregulation phosphorylated ERK1/2 (pERK1/2) pCREB, two molecular indicators neuron excitation. We found cells expressed a vacuolar...
Metabolic reprogramming is a malignant phenotype of cancer. Cancer cells utilize glycolysis to fuel rapid proliferation even in the presence oxygen, and elevated coupled lactate fermentation cancer microenvironment. Although has been recognized as metabolic waste product, it become evident that functions not only an energy source but signaling molecule through receptor G-protein-coupled 81 (GPR81) under physiological conditions. However, pathological role GPR81 remains unclear. Here, we show...
Midkine (MDK) is a heparin-binding growth factor that highly expressed in many malignant tumors, including lung cancers. MDK activates the PI3K pathway and induces anti-apoptotic activity, turn enhancing survival of tumors. Therefore, inhibition considered potential strategy for cancer therapy. In present study, we demonstrate novel small molecule compound (iMDK) targets MDK. iMDK inhibited cell MDK-positive H441 adenocarcinoma cells harbor an oncogenic KRAS mutation H520 squamous cells,...
Abstract The distribution of cells expressing SARS‐CoV‐2 entry factor angiotensin‐converting enzyme 2 (ACE2) and transmembrane serine protease (TMPRSS2) in human oral tissues were tested. investigation was conducted with normal flesh tissue paraffin‐embedded specimens. ACE2 TMPRSS2 expression detected all subjects the mucosa keratinized stratified squamous epithelia tongue non‐keratinized lip cheek. It found that is expressed cytoplasm on cell membrane mainly stratum granulosum while...
Background/Objectives: The population of Japan has a high life expectancy, but there is room for improvement in terms the country’s healthy expectancy. long period care dependency among Japan’s elderly also major economic health challenge. Dementia factor need care, and its prevention crucial urgent There are recent reports possible association between changes oral function cognitive impairment, details this remain unclear. To clarify relationship poor we conducted an exploratory...
Abstract Anatomical details regarding venous drainage of the head and neck are an important matter for surgeons to avoid unnecessary complications such as hemorrhage. This report describes a case large ring around mandibular condyle found in cadaver. The left maxillofacial region latex-injected embalmed male cadaver (82 years age at death) was dissected. two maxillary veins ran lateral capsule superior notch coursed posteroinferiorly merge, one trunk formed posterior border ramus. It then...
Several biological studies have indicated that hedgehog signaling plays an important role in osteoblast proliferation and differentiation, sonic (SHH) expression is positively correlated with phosphorylated focal adhesion kinase (FAK) Tyr397. However, the relationship between them their process of normal fracture repair has not been clarified yet. Immunohistochemical analysis revealed SHH pFAK Tyr397 were expressed bone marrow cells was also detected ALP-positive osteoblasts near...
Abstract Members of matrix metalloproteinase (MMP) family promote cancer cell migration, invasion, and metastasis through alteration the tumor milieu, intracellular signaling pathways, transcription. We examined gene expression signatures colon adenocarcinoma lines with different metastatic potentials found that rapidly cells powerfully expressed genes encoding MMP3 MMP9. The non‐proteolytic PEX isoform proteolytic isoforms MMPs were significantly in vitro. Knockdown attenuated migration...
Abstract Since the SOX2 amplification was identified in lung squamous cell carcinoma (lung SCC), transcriptional downstream targets have been actively investigated; however, such are often line specific. Here, order to identify highly consensus genes SCC cells, we used RNA-seq data from 178 specimens (containing tumor and tumor-associated cells) analyzed correlation between previously-reported -controlled SCC. In addition, another dataset 105 non-small cancer lines (NSCLC; including 4 lines)...
Abstract Low‐intensity pulsed ultrasound (LIPUS) has been used as an adjunct to fracture healing therapies, but the mechanisms underlying its action are not known. We reported that sonic hedgehog (SHH) signaling was activated in osteoblasts at dynamic remodeling site of a bone fracture. Mechanical stimulation is crucial factor remodeling, and it related primary cilia sensor signaling. Here we observed LIPUS promoted callus formation accord with Gli2‐positive cells after 14 days mouse femur...