A5033941417- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Rheumatoid Arthritis Research and Therapies
- Venous Thromboembolism Diagnosis and Management
- Bone health and treatments
- Acute Myocardial Infarction Research
- Systemic Lupus Erythematosus Research
- Bone health and osteoporosis research
- Pain Mechanisms and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Hip disorders and treatments
- Bone Metabolism and Diseases
- ATP Synthase and ATPases Research
- Inflammatory mediators and NSAID effects
- Musculoskeletal synovial abnormalities and treatments
- Bone and Joint Diseases
- Atrial Fibrillation Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Peptidase Inhibition and Analysis
- Polyamine Metabolism and Applications
- Biosimilars and Bioanalytical Methods
- Autoimmune and Inflammatory Disorders Research
Mie University
2016-2025
Weatherford College
2023
Shine
2021-2022
Yamagata University
2021
University of Shizuoka
2020
Osaka University
2006-2017
Karlsruhe Institute of Technology
2011
Soka University
2009
Kagawa University
2002
Orthopedic One
2000
Multiple myeloma patients experience severe bone pain (MMBP) that is undertreated and poorly understood. In this study, we studied MMBP in an intratibial mouse xenograft model employs JJN3 human multiple cells. model, mice develop associated with increased sprouting of calcitonin gene-related peptide-positive (CGRP+) sensory nerves dorsal root ganglia (DRG) upregulation phosphorylated ERK1/2 (pERK1/2) pCREB, two molecular indicators neuron excitation. We found cells expressed a vacuolar...
Increased production of calcitonin gene-related peptide (CGRP) in sensory neurons is implicated inflammatory pain. The site acidic due to proton release from infiltrating cells. Acid activation peripheral nociceptors relays pain signals the CNS. Here, we examined whether acid activated transient receptor potential vanilloid subtype 1 (Trpv1), a widely recognized acid-sensing nociceptor and subsequently increased CGRP expression. Chemically induced inflammation was associated with thermal...
Background: Complications associated with metal-on-metal (MOM) prostheses, such as adverse reactions to metal debris (ARMDs), include pseudotumor (PT) formation, metallosis, and soft tissue necrosis. High short-term failure rates have been reported for various MOM total hip arthroplasties (THAs) due ARMDs. ARMDs in THAs can potentially lead secondary modes, dislocation or infection. Objectives: This study aims examine the cumulative incidence of revisions periprosthetic joint infection (PJI)...
Bi-cruciate retaining (BCR) total knee arthroplasty (TKA) is considered to provide improved clinical function and kinematics compared with conventional TKA, but it unclear which factors affect outcomes after BCR TKA. This study aimed investigate whether rotational alignment of the femoral tibial components mismatch between affected early according 2011 version Knee Society Score (2011KSS). retrospective cohort included 39 knees that underwent Rotational were measured by computed tomography...
Decorin, the prototype of an expanding family small leucine-rich proteoglycans, is involved in a number cellular processes including matrix assembly, fibrillogenesis and control cell proliferation. In this study, we investigated role decorin suppressing tumor aggressiveness bone metastases. We used metastatic breast cancer line, MDA-MB-231, to show that causes marked growth suppression bothin vitro vivo. A cytomegaloviral vector containing transgene caused greatly reduced growth, motility...
Abstract The purpose of this study was to determine which factors contribute patient satisfaction and expectations after total knee arthroplasty (TKA). A 109 patients (130 knees) with osteoarthritis who underwent primary TKA navigation were studied. Intraoperative mediolateral laxity measured. including that affected evaluated using the 2011 Knee Society Score. Patient correlated positively symptoms functional activities, negatively old age in univariate analysis. Multivariate analysis...
Abstract Curcumin is a naturally occurring p300-histone acetyltransferase (p300-HAT) inhibitor that suppresses cardiomyocyte hypertrophy and the development of heart failure in experimental animal models. To enhance therapeutic potential curcumin against failure, we produced series synthetic analogues investigated their inhibitory activity p300-HAT. The compound with strongest was further evaluated to determine its effects on pressure overload-induced mice. We synthesised five found have...
We have developed a ferromagnetic bone cement as thermoseed to generate heat by hysteresis loss under an alternate magnetic field. This material resembles bioactive in composition, with portion of the glass ceramic component replaced magnetite (Fe3O4) powder. The temperature this rises proportion weight ratio powder, volume thermoseed, and intensity heat-generating ability implanted into rabbit human cadaver tibiae was investigated applying field maximum 300 Oe 100 kHz. In system, it is very...
To compare the effectiveness of methotrexate (MTX) as initial therapy in patients with late-onset and younger-onset rheumatoid arthritis (LORA YORA).
The purpose of this study was to determine the prevalence adverse reactions metal debris (ARMD) following large-diameter metal-on-metal total hip arthroplasty. authors examined potential for using magnetic resonance imaging screen pseudotumors in 108 hips 2 years postoperatively. Serum cobalt and chromium concentrations were measured 80 that underwent unilateral considered aseptic lymphocyte-dominated vasculitis-associated lesions be ARMD compared ion levels between with (ARMD group) no...
Abstract The present study aimed to define the prevalence of pain persisting after total knee arthroplasty (TKA) and determine impact neuropathic pain. Knee TKA was evaluated in 154 patients (222 knees with osteoarthritis) using a numerical rating scale (NRS) followed up for mean 4.7 years. were classified according whether they had no or mild (NRS ≤ 3), moderate-to-severe > then assigned groups nociceptive, unclear, based on responses painDETECT questionnaires. Risk factors these types...
Intraoperative navigation systems have been shown to improve the accuracy of acetabular component insertion in total hip arthroplasty (THA). The purpose this study was investigate cup orientation primary THA using an image-free system.A 107 consecutive cementless THAs system were performed from February 2017 March 2020 (the group). As a control group, 77 retrospective cases who underwent with manual implant-techniques between 2012 and April included. Postoperative radiographic inclination...