A5008747331- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Ear and Head Tumors
- Hedgehog Signaling Pathway Studies
- Trigeminal Neuralgia and Treatments
- Bone Tumor Diagnosis and Treatments
- Viral-associated cancers and disorders
- Soft tissue tumor case studies
- Histiocytic Disorders and Treatments
- Head and Neck Anomalies
- Dental Radiography and Imaging
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Oropharyngeal Anatomy and Pathologies
- Neuropeptides and Animal Physiology
- Facial Nerve Paralysis Treatment and Research
- HER2/EGFR in Cancer Research
- Genetic Syndromes and Imprinting
- Lymphoma Diagnosis and Treatment
- Infectious Diseases and Mycology
- Hemoglobin structure and function
- Sarcoma Diagnosis and Treatment
- Actinomycetales infections and treatment
- Parvovirus B19 Infection Studies
Okayama University
2016-2025
Tsuyama Chuo Hospital
2015-2024
Okayama University Hospital
2024
Pharmaceutical Biotechnology (Czechia)
2015-2020
Okayama Central Hospital
2020
Okayama Red Cross General Hospital
2015
Dokkyo University
2005-2006
Dokkyo Medical University Saitama Medical Center
2005-2006
University of Pennsylvania
1994
Abstract Patients with Prader–Willi syndrome (PWS) are recognized to have a tendency of sudden, unexpected death (SED), but its exact cause is unknown because paucity such case reports. Since growth hormone (GH) treatment was applied PWS patients worldwide, several cases been reported. However, whether the therapy directly related their SED remains unknown, too. We collected 13 deceased (Group A, aged 9 months 34 years) who had never received GH therapy, and seven B, all boys 0.7–15 having...
ABSTRACT We report a rare case in which metallic foreign body remained undetected patient's maxilla for nearly 40 years after childhood bicycle accident. Despite the accident, implant place without causing infection due to lack of imaging studies at time. The metal was accidentally discovered during routine dental examination later and subsequently surgically removed. This highlights importance comprehensive dangers overlooking bodies, especially vulnerable head neck region. patient, 53 old...
Abstract Growth hormone (GH) therapy for short stature in patients with Prader–Willi syndrome (PWS) has started worldwide, and various favorable effects have been reported. However, the possibility of progression scoliosis arises as a new problem GH therapy. In this study, we analyzed whether 72 who followed up our hospital such problem. They included 46 males 26 females (41 31 without it) aged from one to 49 years. Consequently, 33 (45.8%) had Cobb angle >10 degrees. Twenty (48.8%)...
Abstract Low‐intensity pulsed ultrasound (LIPUS) has been used as an adjunct to fracture healing therapies, but the mechanisms underlying its action are not known. We reported that sonic hedgehog (SHH) signaling was activated in osteoblasts at dynamic remodeling site of a bone fracture. Mechanical stimulation is crucial factor remodeling, and it related primary cilia sensor signaling. Here we observed LIPUS promoted callus formation accord with Gli2‐positive cells after 14 days mouse femur...
Abstract Background Squamous cell carcinoma (SCC) of the dorsum tongue is extremely rare, and it clinically resembles various benign lesions. Somatic mutations in TP53 some driver genes were implicated development SCC; however, somatic genetic characteristics dorsal SCC remain unknown. With a detailed analysis gene SCC, we aimed to better understand its biology. Methods Four cases initially occurring on evaluated for clinical histological findings immunohistochemical expression p53 p16. Gene...
Epidermal growth factor (EGF) is overexpressed in many cancers and associated with worse prognosis. EGF binds to its cell surface receptor (EGFR), which induces EGFR phosphorylation. Phosphorylated (p‑EGFR) translocated into the nucleus, increases cancer activity. Nicotine, one of main components tobacco, absorbed through pulmonary alveoli mucosal epithelia head neck region by smoking moves blood. Nicotine blood nicotinic acetylcholine (nAChR) central nervous system serves a crucial role...
Sonic hedgehog (SHH) and its signaling have been identified in several human cancers, increased levels of expression appear to correlate with disease progression metastasis. However, the role SHH bone destruction associated oral squamous cell carcinomas is still unclear. In this study we analyzed played by gingival carcinoma-induced jawbone destruction. From an analysis surgically resected lower carcinoma mandible samples, found that was highly expressed tumor cells had invaded matrix. On...
Aim Although uncommon, medical emergencies arise in general dental practice. Inadequate data on their severity and frequency makes targeting education for practitioners difficult. This also planning unexpected events challenging collaborating with emergency physicians burdensome. We aimed to clarify the incidence characteristics of a outpatient department’s emergencies. Methods single‐center, retrospective, observational study was undertaken patients who visited department Okayama University...
Background/Aim: Cancer research has been conducted using cultured cells as part of drug discovery testing, but conventional two-dimensional culture methods are unable to reflect the complex tumor microenvironment. On other hand, three-dimensional cultures have recently attracting attention in vitro models that more closely resemble vivo physiological environment. The purpose this study was establish a 3D method for oral cancer and verify its practicality. Materials Methods: Three-dimensional...
Background: Tachykinin 3 (TAC3) and its preferred tachykinin receptor (TACR3) that are prominently detected in the central nervous system, play significant roles physiological development specifically human reproductive system. The of TAC3/TACR3 oral squamous cell carcinoma unknown. Materials Methods: We examined expression pattern clinically-resected samples using immunohistochemistry immunofluorescence analysis. Results: found even though level TACR3 was negative normal epithelium, it...
Head and neck squamous cell carcinomas (HNSCCs) frequently invade the bones of facial skeleton. Semaphorin 4D (Sema4D) is an axon guidance molecule produced by oligodendrocytes. Sema4D was also identified in bone microenvironment many cancer tissues including HNSCC. To date, however, role cancer-associated disease still unknown. This first study to demonstrate invasion cancer. In clinical tissue samples lesion HNSCC, detected at high levels, its expression correlated with insulin-like growth...
Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC not yet well understood. In this study, we analyzed SHH OSCC.We examined expression pattern and signal proteins clinically resected samples by immunohistochemistry. We also evaluated function using inhibitor cyclopamine vivo vitro proliferation, migration angiogenesis analyses.We found that was highly expressed human tongue OSCC, whereas patched (PTCH1),...
Bone destruction of maxillary and mandibular bone by invasive oral squamous cell cancer (OSCC) raises various problems in the management patients, resulting poor outcomes survival. However, mechanism behind OSCC remains unclear. High-mobility group box 1 (HMGB1), a highly conserved ubiquitous nuclear non-histone DNA-binding protein, has been demonstrated to be secreted aggressive cancers regulate osteoclastogenesis, central player during destruction. We therefore reasoned that HMGB1 OSCCs...
Advanced head and neck cancer (HNC) can invade facial bone cause pain, thus posing a significant challenge to the quality of life patients presenting with advanced HNC. The present study was designed investigate HNC pain (HNC‑BP) in an intratibial mouse xenograft model that utilized cell line (SAS cells). These mice develop HNC‑BP is associated expression phosphorylated ERK1/2 (pERK1/2), which molecular indicator neuron excitation dorsal root ganglia (DRG) sensory neurons. Our experiments...
A previously uncharacterized type of sickled cell was found in venous blood patients with sickle disease when collected without exposure to air and fixed immediately 1% glutaraldehyde solution equilibrated 5% oxygen. These cells were either elongated, resembling irreversibly (ISCs), or nonelongated, a raisin-like shape. Both types assumed normal discoidal shape upon full oxygenation. Since these exist only under partially oxygenated conditions, they are described as (POSCs). POSCs...
The management of medication-related osteonecrosis the jaw (MRONJ) is controversial. To date, there no established treatment for cases advanced stage 3 MRONJ osteoporosis in elderly patients. An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred us treatment. She had a vertebral compression concurrently and started subcutaneous injection teriparatide. After 18 months teriparatide pathological healed functional recovery...
The process of fracture healing consists an inflammatory reaction and cartilage bone tissue reconstruction. cytokine interleukin-1β (IL-1β) signal is important major factor in healing, whereas its relevance to retinoid receptor (an RAR inverse agonist, which promotes endochondral formation) remains unclear. Herein, we investigated the expressions IL-1β retinoic acid gamma (RARγ) a rat model effects presence one several agonists on chondrocytes. An immunohistochemical analysis revealed that...
Malignant melanoma is a tumor with poor prognosis that can metastasize distally at an early stage. Terrein, metabolite produced by Aspergillus terreus, suppresses the expression of angiogenin, angiogenic factor. However, pharmacological effects natural terrein have not been elucidated, because only small amount be extracted from large fungal cultures. In this study, we investigated antineoplastic on human malignant cells and its underlying mechanisms.