A5050818356- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
- Dermatology and Skin Diseases
- Otolaryngology and Infectious Diseases
- Nasal Surgery and Airway Studies
- Head and Neck Anomalies
- Pharmacogenetics and Drug Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Sinusitis and nasal conditions
- PARP inhibition in cancer therapy
- Voice and Speech Disorders
- Psoriasis: Treatment and Pathogenesis
- Receptor Mechanisms and Signaling
- Biomarkers in Disease Mechanisms
- Body Composition Measurement Techniques
- Dysphagia Assessment and Management
- Ear and Head Tumors
- Synthesis and Biological Evaluation
- Reconstructive Surgery and Microvascular Techniques
Shimane University
2011-2022
Nihon University
2004-2017
Yamagata University
2015
Kyushu University
2005-2006
CYP4F2, a member of the cytochrome P450 family, acts mainly as an enzyme and is involved not only in metabolism leukotriene B4, but also that arachidonic acid. It converts acid to 20-hydroxyeicosatetraenoic (20-HETE), metabolite regulation vascular tone brain. The aim this study was assess association between human CYP4F2 gene cerebral infarction (CI), using haplotype-based case-control with separate analyses data from gender groups.A total 175 CI patients 246 control subjects were genotyped...
BackgroundElastin microfibril interfacer 1 (EMILIN-1) is a negative regulator of the transforming growth factor-β (TGF-β) signaling, which involved in blood pressure (BP) homeostasis. Emilin1 knockout mice display elevated BP. The aim present study was to assess association between human EMILIN1 gene and essential hypertension (EH) using haplotype-based case–control study.
Oxidative DNA damage is involved in the pathophysiology of essential hypertension (EH), which a multifactorial disorder. Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/REF-1) an base excision repair pathway oxidatively damaged DNA, addition to having reducing properties that promote binding redox-sensitive transcription factors. Blood pressure APE1/REF-1-knockout mice reported be significantly higher than wild-type mice. The aim this study was investigate relationship...
Sublingual immunotherapy (SLIT) has been considered to be a painless and efficacious therapeutic treatment of allergic rhinitis which is known as type I allergy nasal mucosa. Nevertheless, its mechanisms need further investigated. In this study, we constructed an effective murine model sublingual in rhinitis, mice were sublingually administered with ovalbumin (OVA) followed by intraperitoneal sensitization challenge OVA. Sublingually treated showed significantly decreased specific IgE...
Lymphotoxin- (LTA), a member of the tumor necrosis factor family, is cytokine produced by lymphocytes. The substance LTA mediates wide variety inflammatory, immunostimulatory, and antiviral responses. In 2002, was identified as major risk for myocardial infarction (MI) in Japanese individuals, large-scale case-control study using 92,788 gene-based single-nucleotide polymorphism (SNP) markers whole human genome. Essential hypertension (EH) thought to be multifactorial disorder involved...
Currently, there is no scale to subjectively assess postoperative oral dysfunction in patients with cancer. The purpose of this study was evaluate the reliability and validity Postoperative Oral Dysfunction Scale (POD-10) that we developed. Between September 2019 August 2021, 62 eligible cancer (median age, 72 years; 42 men 20 women) were enrolled study. Cronbach’s alpha coefficient, which indicates internal consistency scale, 0.94, intraclass correlation reproducibility, 0.85 (95%...
The thyroid gland is resistant to microbial infection, because of its organ characteristics such as encapsulation, iodine content, and rich blood supply. Therefore, acute suppurative thyroiditis (AST), a bacterial infection the gland, rarely seen. AST typically takes places on left side neck region in children, coincidence piriform sinus fistula, most common route infection. also usually seen immunocompromised hosts. Herein, we report rare case right lobe adult woman without any condition.A...
OK-432, a preparation of low-virulence strain (Su) Streptococcus pyogenes (Group A) killed by penicillin and lyophilized, is stiff inducer Th1 cytokines, exerts anti-cancer effects in tumor-bearing mice. OK-432 has been reported to consist many bacterial components, such as peptidoglycan, M-protein, etc. However, it yet be ascertained which component induces T helper 1 (Th1) responses. For the last decade, Toll-like receptor (TLR) family proteins are well elucidated play role recognizing...
Deep neck abscesses represent an emergency otolaryngological disease. We analyzed 25 patients with deep treated in our hospital between 1998 and 2009. The mean age of the was 58.9 years. investigated age, primary focus, extension abscess, treatment, causative bacteria prognosis. cause pharyngeal infection 9 cases (36%), odontogenic 5 (20%), peritonsillar abscess 3 (12%), a foreign body (fish bones) (12%). Each case classified according to degree extent diagnosed CT imaging. were localized...
腺様嚢胞癌は頭頸部領域における全腫瘍の1%に満たない比較的まれな腫瘍である。一般的に発育は緩慢であり生物学的悪性度が低い腫瘍とされているが，局所再発や遠隔転移が多いことが特徴とされ，中には不幸な転機をとる症例もある。予後因子として臨床的には腫瘍の大きさ，手術による腫瘍摘出の際の安全域の有無，神経浸潤の有無が挙げられる。組織像は環状型，篩状型，充実型などの組織が混在しており，充実型を多く含むと転移を来しやすく予後不良とされている。今回，我々は当院において1986年1月から2009年1月までに島根大学耳鼻咽喉科にて治療された頭頸部腺様嚢胞癌10症例において，腫瘍の病理組織学的特性と患者の臨床経過の関連について検討したので報告する。対象は男性7例，女性3例，年齢は43歳から80歳であった。原発部位は鼻腔3例，顎下腺2例，耳下腺2例，中咽頭1例，外耳道2例であった。遠隔転移部位としては肺が最も多く，他に肝臓，皮膚，骨に転移を認めた。病理組織学的検討では，Szantoらの分類でgrade Iが2例，grade IIが6例，grade...
Japanese traditional medicine, Senn-kinn-naidaku-sann up
Acute low-tone sensorineural hearing loss (ALHL) is generally has a relatively good prognosis. We have often found in long-term following-up, however, that ALHL relapses, recurs or develops into Meniere's disease. Diagnostic criteria of the Altitude Deafness Research Group Ministry Health, Labor, and Welfare Japan, define as low-tone-disorder without vertigo which cochlear symptoms -ear fullness, tinnitus, deafness- develop suddenly. Over last five years, we treated 31 cases ALHL, about half...
Seven patients with inflammatory paranasal sinus disease and cystic lesions of the sinuses accompanied by visual disturbances were surgically treated at our institution between 1994 2005. The average age was 54.3 years old. Lesions found in ethmoidal 4 patients, sphenoidal maxillary 2 patients. Six first visited Ophthalmology Department one patient Otolaryngology Department. improved after surgery 5 but not interval symptom onset 5.2 days group which 36 did improve. Early diagnosis prompt...
Background: Microbial infection or exposure to endotoxin later in life exacerbates established asthma. Mast cells are involved the exacerbation of This involves a toll-like receptor (TLR)–mediated response mast cells. In clinical practice otolaryngology, otolaryngologists experience an nasal congestion when infectious rhinitis develops patients with allergic rhinitis, but mechanisms unknown. Therefore, this study investigated effect lipopolysaccharide (LPS) on using mouse model. Methods:...
Background: Oxatomide, a H1-receptor antagonist, exerts besides its well-known anti-allergic potential an array of anti-inflammatory activities.We wondered whether oxatomide might influence the release IL-8 from human epithelial cells activated with agonists TLR2, which mainly expresses on airway cells.Methodology: We used lung cell line A549 and primary Human nasal for our in vitro studies.IL-8 releases these lines were determined by enzyme immunoassay.NF-kB was analysed Luciferase reporter...
Sublingual immunotherapy has been considered to be a painless and effective therapeutic treatment of patients with allergic rhinitis. Its mechanism action elucidated, but there are still controversies among many reports between clinical efficacy laboratory data. Therefore, its needs investigated further by using promising animal models such as rodents monkeys.Bearing this in mind, our present study, we successfully constructed an murine model for sublingual (SLIT) rhinitis which mice were...
Deep neck abscesses represent an emergency otolaryngological disease. We analyzed 25 patients with deep treated in our hospital between 1998 and 2009. The mean age of the was 58.9 years. investigated age, primary focus, extension abscess, treatment, causative bacteria prognosis.The cause pharyngeal infection 9 cases (36%), odontogenic 5 (20%), peritonsillar abscess 3 (12%), a foreign body (fish bones) (12%). Each case classified according to degree extent diagnosed CT imaging. were localized...