Recent animal studies showed that osteocalcin action is related to not only bone metabolism but also glucose and fat mass. We investigated the relationship between two formation markers, serum bone-specific alkaline phosphatase, metabolism, adiponectin, amount of mass as well atherosclerosis parameters in men postmenopausal women with type 2 diabetes.A total 179 149 were recruited consecutively, radiographic biochemical characteristics collected. Brachial-ankle pulse wave velocity (baPWV)...

Although patients with type 2 diabetes (T2DM) have an increased risk of hip fracture, vertebral fracture (VF) and its association BMD are still unclear. We examined Japanese T2DM (161 men >50 yr 137 postmenopausal women) non-DM controls (76 622, respectively) by lateral spine radiography DXA at the lumbar (L), femoral neck (FN), radius (R). Logistic regression analysis adjusted for age, body mass index, L-BMD showed that presence was independent factor prevalent VFs in women (OR = 1.86, p...

Although type 2 diabetic patients are at increased risk of fractures, bone mineral density (BMD) may not be useful for assessing the risk. Recent studies have reported that content pentosidine (PEN) is associated with its plasma concentration and fragility.To examine association between serum PEN levels vertebral fractures (VFs) in Japanese (77 males older than 50 yr 76 postmenopausal females), we compared parameters including BMD, PEN, bone-specific alkaline phosphatase, urinary...

Adiponectin is a key mediator of the metabolic syndrome that caused by visceral fat accumulation. and its receptors are known to be expressed in osteoblasts, but their actions with regard bone metabolism still unclear. In this study, we investigated effects adiponectin on proliferation, differentiation, mineralization osteoblastic MC3T3-E1 cells.Adiponectin receptor type 1 (AdipoR1) mRNA was detected cells RT-PCR. The adenosine monophosphate-activated protein kinase (AMP kinase)...

Patients with type 2 diabetes mellitus (T2DM) patients are at increased risk of vertebral fractures (VFs) compared non-T2DM individuals, because poor bone quality. Recent studies in nondiabetic subjects have shown that elevated sclerostin levels associated VFs independent mineral density (BMD).We aimed to investigate the association between and T2DM.We conducted a cross-sectional observational study 146 postmenopausal women 175 men over 50 years old. Sclerostin were without confirmed by...

Type 1 diabetes mellitus is known to be associated with reduced bone mass and increased fractures. This thought due a decrease in osteoblastic formation rather than an increase osteoclastic resorption, but the precise mechanism unknown. In this study, we examined whether or not high glucose advanced glycation end-products (AGEs), which play key roles pathogenesis complications of diabetes, affect differentiation MC3T3-E1 cells. First, cells were incubated media containing either 22 mM...

Although, adiponectin might be associated with bone metabolism, the relationships between serum and mineral density (BMD) as well vertebral fracture in type 2 diabetes are still unclear.We investigated each of total high molecular weight (HMW) versus BMD, markers, presence fractures a 231 men 170 post-menopausal women diabetes.Multiple regression analysis adjusted for age, duration diabetes, BMI, creatinine, HbA(1c) showed that was negatively correlated BMD at total, lumbar spine, femoral...

Patients with type 2 diabetes (T2DM) have an increased risk of vertebral fractures (VF) compared non-T2DM controls due to poor bone quality. The aim this study was investigate the association between VF and turnover. We clinical parameters, such as serum PTH osteocalcin (OC), hospital-based Japanese T2DM patients (123 postmenopausal women 132 men over 50 yr old) medical checkup-based (189 51 men). OC levels investigated, risks were for four subgroups classified by values. had lower than both...

OBJECTIVE Patients with type 2 diabetes are known to have an increased risk for fracture compared non–type diabetic control subjects, despite having higher bone mineral density (BMD). We previously showed that serum pentosidine, one of the advanced glycation end products (AGEs), was associated prevalent vertebral fractures (VFs) in those diabetes. The involvement endogenous secretory receptor AGEs (esRAGE) VFs diabetes, however, is still unknown. RESEARCH DESIGN AND METHODS parameters...

Although several experiments show that adiponectin is associated with bone metabolism, a relationship between and markers still unclear. We monitored chronological changes in hyperglycemia, serum adiponectin, during glycemic control type 2 diabetes analyzed relationships among these parameters.A total of 50 Japanese patients poorly controlled [initial hemoglobin A(1c) (HbA(1c)) = 10.0 +/- 2.5%] were recruited, biochemical data collected before after for month. Of formation markers,...

Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney (CKD). Both traditional and CKD-related factors are associated CVD CKD patients. Traditional that play an important role atherosclerotic process directly contribute to a higher risk coronary artery early-stage CKD. Among factors, CKD-mineral bone disorder plays critical pathomechanism nonatherosclerotic diseases, which increases cardiovascular morbidity mortality advanced Higher serum phosphate levels...

Immunoglobulin (Ig) A nephropathy (IgAN) is characterized by mesangial deposits of IgA1 and C3, often with co-deposits IgG. We attempted to clarify the clinical significance IgG deposition in patients IgAN.We retrospectively reviewed 57 who were diagnosed IgAN on basis pathological examination renal biopsy specimens obtained between October 2006 December 2010. Subjects divided into two groups: IgA+IgG (IgA-IgG) group (n = 29) IgA alone (IgA) 28). The study outcome was complete remission...

Some observational studies have revealed an association between excessive aldosterone levels and reduced bone mineral density (BMD). However, whether patients with primary aldosteronism (PA) are at higher risk of fracture than healthy individuals remains unclear.This study aimed to clarify PA represents a factor for vertebral (VF).We enrolled 56 age- sex-matched individuals. Serum urinary biological parameters, BMD, presence VFs were evaluated in both groups. We compared parameters control...

Background An assessment of bone strength based on mineral density (BMD) underestimates the risk fracture in patients with diabetes mellitus (T2DM). However, using trabecular score (TBS) for estimating microarchitecture, previous studies showed that fragility is associated deterioration microstructure concomitantly decreased BMD. This study was conducted to clarify which these skeletal-related factors had a more prominent relationship fragility. Research design and methods A retrospective...