A5035823678- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Surgical Simulation and Training
- Minimally Invasive Surgical Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Occupational and environmental lung diseases
- Enhanced Recovery After Surgery
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Appendicitis Diagnosis and Management
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Diverticular Disease and Complications
Hokkaido University
2015-2024
Japan Society of Laparoscopic Colorectal Surgery
2024
Hokkaido University Hospital
2009-2024
Tokyo Women's Medical University Adachi Medical Center
2024
Nippon Medical School
2024
Hokkaido University of Science
2021-2023
Sapporo Kosei General Hospital
2008-2010
Kurume University
2006-2007
Toranomon Hospital
2005-2006
Preoperative chemoradiotherapy (CRT) and surgical resection are the standard treatment for locally advanced rectal cancer (LARC). Combining immune checkpoint inhibitors with radiation suggests a promising approach enhancing efficacy. We investigated efficacy of CRT followed by nivolumab surgery in patients LARC.In phase I, we feasibility sequentially combined CRT, 5 cycles nivolumab, radical surgery. In II, microsatellite stable (MSS) instability-high (MSI-H) LARC were evaluated.Three I...
Objectives: Recent studies have shown that the high affinity of mesothelin-CA125 interaction might cause intracavitary tumor metastasis. We examined clinicopathologic significance and prognostic implication mesothelin CA125 expression in pancreatic ductal adenocarcinoma. Methods: Tissue samples from 66 adenocarcinomas were immunohistochemically examined. Proportion intensity constituent cells with analyzed classified as high-level expression, defined by more than 50% and/or moderate to...
It is unknown as to how liver metastases are correlated with host immune status in colorectal cancer. In this study, we found that IL6, a proinflammatory cytokine produced tumor-bearing states, promoted the metastatic colonization of colon cancer cells association dysfunctional antitumor immunity. IL6-deficient mice, CT26 was reduced, and effector function CD8+ T cells, well IL12 production by CD11c+ dendritic were augmented vivo mice exhibited enhanced IFN-AR1-mediated type I interferon...
Conquering immunosuppression in tumor microenvironments is crucial for effective cancer immunotherapy. It well known that interleukin ( IL )‐6, a pleiotropic cytokine, produced the tumor‐bearing state. In present study, we investigated precise effects of ‐6 on antitumor immunity and subsequent tumorigenesis hosts. CT 26 cells, murine colon cell line, were intradermally injected into wild‐type ‐6‐deficient mice. As result, found growth was decreased significantly mice compared with reduction...
4100 Background: Chemoradiotherapy (CRT) followed by radical surgery (S) is standard therapy for patients (pts) with locally advanced rectal cancer (LARC). Sequential use of an anti-PD-1 antibody after radiation demonstrates synergistic effects in vivo models, and effective pts microsatellite instability-high (MSI-H) metastatic colorectal (mCRC). We studied nivolumab (nivo) S following CRT (50.4 Gy capecitabine 1,650 mg/m 2 ) T 3–4 N any M 0 LARC. Methods: After the quality-assured CRT, 240...
Mesothelin is expressed in various types of malignant tumour, and we recently reported that expression mesothelin was related to an unfavourable patient outcome pancreatic ductal adenocarcinoma. In this study, examined the clinicopathological significance gastric cancer, especially terms its association with staining pattern. Tissue specimens from 110 cancer patients were immunohistochemically examined. The proportion intensity tumour cells analysed, localisation classified into luminal...
A patient with pulmonary metastasis of colon cancer was treated artificially synthesized helper/killer‐hybrid epitope long peptide (H/K‐HELP) MAGE‐A4 antigen. The vaccinated MAGE‐A4‐H/K‐HELP combined OK432 and Montanide ISA‐51. There were no severe side‐effects except for a skin reaction at the injection site. induced MAGE‐A4‐specific Th1 Tc1 immune responses production complement‐fixing IgG antibodies. Tumor growth carcinoembryonic antigen tumor marker significantly decreased in final...
Conversion to laparotomy is among the serious intraoperative complications and carries an increased risk of postoperative complications. In this cohort study, we investigated whether or not Endoscopic Surgical Skill Qualification System (ESSQS) affects conversion rate patients undergoing laparoscopic surgery for rectal cancer.
Mesothelin is expressed in various types of malignant tumors, and we recently reported that the expression mesothelin was related to unfavorable patient outcome pancreatic ductal adenocarcinoma gastric adenocarcinoma. In this study, examined clinicopathological significance extrahepatic bile duct cancer (EHBDCA), especially terms its association with staining pattern. Tissue samples from 61 EHBDCA (16 hilar cholangiocarcinoma, 17 upper adenocarci-noma, 20 middle 8 distal adenocarcinoma) were...
Abstract Background The Endoscopic Surgical Skill Qualification System (ESSQS) was introduced in Japan to improve the quality of laparoscopic surgery. This cohort study investigated short- and long-term postoperative outcomes colorectal cancer procedures performed by or with qualified surgeons compared for unqualified surgeons. Methods All resections from 2010 2013 11 Japanese hospitals were reviewed retrospectively. categorized as without ESSQS qualification patients' clinical, pathological...
Abstract Background Arginase-1 (ARG1), a urea cycle-related enzyme, catalyzes the hydrolysis of arginine to and ornithine, which regulates proliferation, differentiation, function various cells. However, it is unclear whether ARG1 controls progression malignant alterations colon cancer. Methods We established metastatic colonization mouse model overexpressing murine cancer CT26 cells investigate activation was related malignancy in vivo. Living cell numbers migration ability were evaluated...
108 Background: In VOLTAGE-A, CRT (50.4 Gy with capecitabine of 1,650 mg/m 2 ) followed by five cycles consolidation Nivo (240 mg q2 weeks [W]) and radical surgery showed 30% pathological complete response (pCR) in pts MSS 60% MSI-H T 3–4 N any M 0 LARC. Here, we report survival outcomes functional results. Methods: All 39 5 were included the VOLTAGE-A from Jan 2017 to Oct 2019. Survival outcomes, late adverse events, patient-reported outcome measurements for urogenital anal functions...
The aim of the present study was to investigate safety and immunological responses personalized peptide vaccination in combination with oral administration a 5‐fluorouracil derivative (TS‐1) advanced gastric or colorectal carcinoma patients. Eleven patients (four cancer seven cancer) who failed improve by prior TS‐1‐based chemotherapies were enrolled this study. Peptides be administered determined based on presence peptide‐specific cytotoxic T lymphocyte (CTL) precursors peripheral blood...
In gastric cancer, primary systemic chemotherapy is the standard approach for management of patients with initially unresectable metastasis, and it occasionally leads to a reduction in size lesion, which facilitates surgical resection. The aim this study was examine prognosis who were able undergo complete resection following chemotherapy. A total 10 underwent radical surgery stage IV cancer after between 2009 2015 at Department Surgery Hokkaido Social Work Association Obihiro Hospital...
This cohort study investigated short- and long-term postoperative outcomes of laparoscopic procedures for rectal cancer performed with versus without certified surgeons.In Japan, the Endoscopic Surgical Skill Qualification System (ESSQS) evaluates surgical skills deemed essential surgery; however, it is unknown whether this certification contributes to procedural safety.Outcomes resections cStage II III from 2014 2016 at 56 Japanese hospitals were retrospectively reviewed. The impact having...
Spontaneous regression (SR) of many malignant tumors has been well documented, with an approximate incidence one per 60,000–100,000 cancer patients. However, SR colorectal (CRC) is very rare, accounting for less than 2% such cases. We report a case transverse colon in 80-year-old man undergoing outpatient follow-up after surgical treatment early gastric cancer. Colonoscopy (CS) revealed Borrmann type II tumor the measuring 30 × mm. Because patient underwent anticoagulant therapy, we did not...