A5079081610- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Colorectal and Anal Carcinomas
- Metastasis and carcinoma case studies
- Inflammatory Biomarkers in Disease Prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Nutrition and Health in Aging
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Screening and Detection
- Anorectal Disease Treatments and Outcomes
- Soft tissue tumor case studies
- Hernia repair and management
- Immune Cell Function and Interaction
- Stoma care and complications
- Multiple and Secondary Primary Cancers
- Sarcoma Diagnosis and Treatment
- Immune cells in cancer
- Diverticular Disease and Complications
Gunma University
2015-2024
Japan Society of Laparoscopic Colorectal Surgery
2024
Yahoo (United Kingdom)
2024
Weatherford College
2022
Tokyo Metropolitan Komagome Hospital
2021
Gunma University Hospital
2017-2019
Obayashi (Japan)
2013
Universidad Nacional Agraria La Molina
2008
Columbia University
2008
Osaka University
2004
Conversion to laparotomy is among the serious intraoperative complications and carries an increased risk of postoperative complications. In this cohort study, we investigated whether or not Endoscopic Surgical Skill Qualification System (ESSQS) affects conversion rate patients undergoing laparoscopic surgery for rectal cancer.
Background: The mesenteric vessels have many branching patterns. This study clarified the anatomic relationship between superior vein (SMV), right colic artery (RCA), and ileocolic (ICA) using 3-dimensional computed tomography (3D-CT). RCA (RCV) was also examined. Methods: Between April 2006 July 2011, all patients with colorectal cancer underwent multidetector (MDCT) before laparoscopic surgery. 100 most recent consecutive cases were analyzed. 3D-CT images made by combining arterial...
Nutritional disorders due to cancer-related weight loss, such as cancer-impaired food passage, are prominent in many cases of advanced oesophageal cancer. Here, we investigated the nutritional factors that most affect therapeutic effect and prognosis unresectable cancer.One hundred four patients diagnosed with cT4b squamous cell carcinoma were included this study. The values C-reactive protein/albumin ratio, Glasgow Prognostic Score, prognostic index, neutrophil/lymphocyte ratio...
L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers. However, the clinicopathological significance of LAT1 and 4F2 cell surface antigen (4F2hc) patients with colorectal cancer (CRC) unknown. The aim this study was to clarify prognostic expression CRC who underwent surgical resection.Samples from one hundred forty-seven were examined by immunohistochemistry. 4F2hc, Ki-67 labeling index assessed using resected tumor specimens.The positive 4F2c 80% (118/147) 58%...
Tumor‑infiltrating immune cells, such as lymphocytes and macrophages, have been associated with tumor aggressiveness, prognosis treatment response in colorectal cancer (CRC). An scoring system, Immunoscore (IS), based on tumor‑infiltrating T cells stage I‑III CRC, was used to predict prognosis. alternative signature of activation (SIA) reflects the balance between anti‑ pro‑tumoral components. The present study aimed evaluate prognostic value modified IS (mIS) SIA (mSIA) locally advanced...
The glucose-regulated protein 78 (GRP78), also referred to as immunoglobulin heavy chain binding (BiP) (BiP/GRP78), is a major molecular chaperone in the endoplasmic reticulum (ER) and extensively expressed human neoplasms. Although enhanced expression of BiP/GRP78 has been described be associated with poor prognosis gastric cancer (GC), details regarding its prognostic significance remain unclear. aim this study was elucidate role patients GC.Study subjects included 328 who underwent...
The β2-adrenergic receptor (β2-AR) is highly expressed in various human neoplasms and has been considered a novel therapeutic target of cancer treatment. However, the clinicopathological significance β2-AR expression patients with gastric (GC) remains unclear. aim this study was to explore its prognostic significance. A total 331 surgically resected GC were evaluated. Tumor sections stained immunohistochemically for β2-AR. And, we confirmed cell lines by Western blot. 30.5 % patients....
Background/Aim: This study clarified the predictive impact of serum biomarkers on therapeutic sensitivity to nivolumab in patients with gastric cancer (GC). Patients and Methods: The outcomes 27 who received treat postoperative recurrent or unresectable advanced GC were reviewed. Blood testing was performed immediately before after two courses nivolumab. We also focused rate change each blood variable. Results: decrease albumin (Alb) levels (p=0.035) increase lactate dehydrogenase (LDH)...
We aimed to clarify the use of adjuvant chemotherapy and prognosis elderly colorectal cancer patients compared with non-elderly patients, usefulness sarcopenia as an indicator for introduction completion chemotherapy.
Abstract Background Tumor size in pathological T4 (pT4) colorectal cancer (CRC) is associated with oncological prognosis; however, its relation to epithelial‐mesenchymal transition (EMT)‐associated histology unclear. We aimed investigate the association of tumor prognosis and EMT. Methods performed a retrospective analysis 95 patients primary CRC who underwent radical surgery were consecutively diagnosed pT4. Results Both 3‐y disease‐free survival (DFS) cancer‐specific (CSS) significantly...
It is difficult to treat patients with an inoperable sarcoma adjacent the gastrointestinal (GI) tract using carbon ion radiotherapy (C-ion RT), owing possible development of serious GI toxicities. In such cases, spacer placement may be useful in physically separating tumor and tract. We aimed evaluate usefulness by conducting a simulation study dosimetric comparison patient sacral chordoma rectum treated C-ion RT. The was located third fourth spinal segments, extensive contact compressing...
Abstract Anti‐transcription intermediary factor 1γ (anti‐TIF1γ) antibody (Ab) is significantly associated with internal malignancies in adult patients dermatomyositis (DM). Although pathogenesis of cancer‐associated DM unknown, TIF1γ overexpression tumors has been considered to be critical for the development DM. The objective this study was investigate clinical characteristics anti‐TIF1γ Ab‐positive and elucidate risk factors that are potentially malignancy. In addition, we compared...
Introduction: Programmed death-ligand 1 (PD-L1) expression is a prognostic marker for gastric cancer that correlates with tumor diameter and depth of penetration. But the role PD-L1 mechanism(s) employed in initial phase invasion early yet to be understood. Objective: This study aims elucidate during progression cancer, specifically invading submucosa beyond lamina muscularis mucosa. Methods: Using 107 patients pathological submucosal we determined based on staining cell membrane or...
The mammalian target of rapamycin (mTOR) is often activated in several cancers. We focused on two mTOR regulatory mechanisms: oxaliplatin-induced signaling and L-type amino acid transporter 1 (LAT1)-induced activation. High LAT1 expression cancers associated with activation resistance to chemotherapy. However, the significance has not yet been elucidated colorectal cancer (CRC) patients treated post-operative adjuvant Immunohistochemistry was conducted examine membrane 98 CRC who received...
Activating mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) loci are largely predictive of resistance to epidermal growth factor receptor (EGFR) therapy colorectal cancer (CRC). A highly sensitive detection system for KRAS gene is urgently needed; however, conventional methods have issues with feasibility and cost performance. Here, we describe a novel using fluorescence ʻEprobe' capable detecting low level mutations, via real-time PCR, high sensitivity simple usability. We...
Background : With regard to the recurrence of esophageal cancer after surgery, prognosis has improved with progress multimodal perioperative treatment. In this study, pattern, treatment method, and recurrent cases following surgery were retrospectively examined. Materials Methods Three hundred seven patients histologically proven squamous cell carcinoma, adenocarcinoma, others enrolled in study. respect clinicopathologic factors patterns, risk factors, period, for recurrence,...
Abstract Background Although nivolumab (anti-programmed cell death-1 antibody) is a promising approach for advanced gastric cancer (AGC), the response rate remains limited. The aim of this multicenter retrospective study was to determine if clinical features could serve as prognostic factors efficacy in patients with AGC. Methods Fifty-eight AGC who were treated third or later line from October 2017 December 2018 at any five sites enrolled study. correlation between best overall and...
In a surgical operation requiring endoscopy, it is essential to obtain clear endoscopic view. However, often disturbed by the contamination on lens during surgery. No device can clean surface simply and completely. Many surgeons are hampered impaired view distraction repeated cleaning of lens. Therefore, we developed novel endoscope address this problem. The was made 3D-printed rubber-like plastic. It contains syringe filled with saline an aspiration system. would be used intraoperatively...
Abstract Ulcerative colitis (UC) is a DNA damage-associated chronic inflammatory disease; the double-strand break (DSB) repair pathway participates in UC-associated dysplasia/colitic cancer carcinogenesis. The DSB/interferon regulatory factor-1 (IRF-1) can induce PD-L1 expression transcriptionally. However, association of PD-L1/DSB/IRF-1 with sporadic colorectal (SCRC), and cancer, remains elusive. Therefore, we investigated significance PD-L1/DSB using samples from 17 SCRC 12 UC patients...