A5009380934- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Intraperitoneal and Appendiceal Malignancies
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Diverticular Disease and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Immunotherapy and Biomarkers
- Intestinal and Peritoneal Adhesions
- Appendicitis Diagnosis and Management
- Esophageal and GI Pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Intestinal Malrotation and Obstruction Disorders
- Cancer Diagnosis and Treatment
- Anorectal Disease Treatments and Outcomes
- Multiple and Secondary Primary Cancers
- Cancer therapeutics and mechanisms
Jichi Medical University
2016-2025
Japan Society of Laparoscopic Colorectal Surgery
2024
Jichi Medical University Hospital
2015-2024
National Cancer Center Hospital East
2024
Nagaoka University of Technology
2024
Tochigi Medical Center
1968-2024
Koga Hospital
2023
Creative Research Enterprises (United States)
2016
Novem (Netherlands)
2015
Jichi Medical University Saitama Medical Center
2014
Periostin is a unique extracellular matrix protein, deposition of which enhanced by mechanical stress and the tissue repair process. Its significance in normal neoplastic colon has not been fully clarified yet. Using immunohistochemistry immunoelectron microscopy with highly specific monoclonal antibody, periostin was observed close proximity to pericryptal fibroblasts colonic crypts. The pattern decreased adenoma adenocarcinoma, preceding decrease number fibroblasts. immunoreactivity...
Evaluation of pathologic predictors metastases in T1 stage colorectal cancer may be difficult with hematoxylin and eosin (HE) staining alone. The aim this study was to clarify the role by using immunohistochemical Elastica van Gieson (EVG) staining. One hundred twenty-four patients who underwent bowel resection for single from 1990 2004 1 institution were studied. D2-40, EVG staining, CAM5.2 used detect lymphatic invasion, venous tumor budding, respectively. These 3 factors separately...
Potent application of topoisomerase I inhibitor plus PARP has been suggested to be an effective strategy for cancer therapy. Reportedly, mismatch repair (MMR)-deficient colon cells are sensitive inhibitor, presumably due microsatellite instability (MSI) the MRE11 locus. We examined synergy SN-38, active metabolite irinotecan, in combination with olaparib showing different MMR status, such as MSI or stable (MSS) phenotype. Treatment SN-38 and almost halved IC50 a broad spectrum independent...
Abstract Background Anti-tumor effects of radiation therapy (RT) largely depend on host immune function. Adenosine with its strong immunosuppressive properties is an important checkpoint molecule. Method We examined how intra-tumoral adenosine levels modify anti-tumor RT in a murine model using anti-CD73 antibody which blocks the rate-limiting enzyme to produce extracellular adenosine. also evaluated CD73 expression irradiated human rectal cancer tissue. Results LuM-1, highly metastatic...
BackgroundLow-density neutrophils (LDN) have been shown to be increased in peripheral blood patients with various diseases and closely related immune-mediated pathology. However, the frequency function of LDN circulating following abdominal surgery not well understood.MethodsLDN were determined by CD66b(+) cells, which copurified mononuclear cells density gradient preparations surgical patients. The effects purified on T cell proliferation tumor lysis examined vitro. Neutrophil extracellular...
Abstract Accumulating evidence suggests that metformin reduces the incidence and mortality of colorectal cancer (CRC). However, underlying mechanisms have not been fully clarified. The aim this study was to examine pathological characteristics resected CRC from patients treated with for type 2 diabetes mellitus (DM). In total, 267 DM underwent curative colectomy Stage I‐III 53 (19.9%) had medically including metformin. Pathological N‐stage significantly lower in metformin‐treated ( P <...
Colorectal carcinoma (CRC) remains the major cause of cancer death in humans. Although chromosomal structural anomaly is presumed to play an important role carcinogenesis CRC, copy number alterations (CNA) and loss heterozygosity (LOH) have not yet been analyzed extensively at high resolution CRC. Here we aim identify recurrent CNA LOH human CRC with use single nucleotide polymorphism-typing microarrays, reveal their relevance clinical outcome. Surgically resected specimens paired normal...
Abstract Accumulating evidence suggests that IL-1β plays a pivotal role in the pathophysiology of hepatic ischemia–reperfusion (I/R) injury; however, mechanism by which I/R triggers production liver remains unclear. Recent data have shown neutrophils contribute to injury independently inflammasomes regulating maturation. Thus, we investigated maturation and tissue murine model I/R. was released from its deficiency reduced reactive oxygen species generation, apoptosis, inflammatory responses,...
Postoperative adhesions are the major cause of postoperative complications including intestinal obstruction, infertility, and chronic pelvic pain. In order to reduce adhesions, Terumo Corporation (Tokyo, Japan) has developed an adhesion barrier system (TCD-11091) which is easy use at treatment site in various surgical procedures laparoscopic surgeries. We conducted a prospective randomized single-blind study patients who underwent laparotomy with ileostomy. One hundred twenty-six were...
Abstract Aim Peritoneal metastases (PM) frequently occur in patients with gastric cancer and result a poor prognosis. Exosomes play pivotal roles tumor metastasis through the transfer of microRNAs (miRNAs). We examined exosomal miRNA profile peritoneal fluids to identify novel biomarkers reflect burden peritoneum. Methods were isolated from macroscopic (P1) or microscopic (P0CY1) comprehensive expression analysis was carried out. Expressions candidate miRNAs then validated all 58 samples...
Intestinal ischemia/reperfusion (I/R) injury is a life-threatening complication that leads to inflammation and remote organ damage. The NLRP3 inflammasome regulates the caspase-1-dependent release of IL-1β, an early mediator after I/R injury. In this study, we investigated role in mice with intestinal Deficiency NLRP3, ASC, caspase-1/11, or IL-1β prolonged survival injury, but neither nor caspase-1/11 deficiency affected inflammation. caused acute lung (ALI) characterized by inflammation,...
Conversion to laparotomy is among the serious intraoperative complications and carries an increased risk of postoperative complications. In this cohort study, we investigated whether or not Endoscopic Surgical Skill Qualification System (ESSQS) affects conversion rate patients undergoing laparoscopic surgery for rectal cancer.
Objective: To clarify the long-term oncological outcomes and postoperative anal, urinary, sexual functions after laparoscopic surgery for clinical stage I very low rectal carcinoma located near anal canal. Summary Background Data: Laparoscopic is widely applied cancer; however, concerns remain, with some studies showing poorer compared to open surgery. Methods: This single-arm, phase II trial included patients registered preoperatively from 47 institutions in Japan. The planned sample size...
Abstract Background Although extensive research has been conducted on early anastomotic leakage (AL) after sphincter‐sparing surgery, the status of late complications (post‐30 days) received limited attention. These significantly affect a patient's quality life and often lead to permanent stoma creation. Methods This study sub‐analysis phase II trial assessing outcomes laparoscopic surgery for cStage I lower rectal adenocarcinoma (the ultimate trial). included 278 patients who underwent...
Abstract Aim The effect of laparoscopic surgery on sexual function in patients with ultra‐low rectal cancer remains unexplored. This multicentre study evaluated postoperative male located within 5 cm the anal verge. Method A total 139 aged ≤70 years clinical T1‐2N0M0 underwent between January 2014 and March 2017 at 47 institutions. Sexual was assessed using International Index Erectile Function (IIEF‐15) an ejaculation questionnaire preoperatively 3, 6, 12 months postoperatively. Univariate...
Retinol-binding protein 4 (RBP4) is a recently identified adipokine that was involved in insulin resistance. RBP4 predominantly expressed from the liver normal metabolic state to transport retinoids throughout body, but exact physiological function and regulatory mechanisms of adipocyte-derived have not been revealed. We conducted genetic analysis about parameters Japanese Mongolian; minor allele carriers single-nucleotide polymorphism (SNP -803G>A) showed significantly higher BMI men (P =...