A5017487986- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Occupational and environmental lung diseases
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
- Sarcoidosis and Beryllium Toxicity Research
- Eosinophilic Disorders and Syndromes
- Pleural and Pulmonary Diseases
- Pneumonia and Respiratory Infections
- Inhalation and Respiratory Drug Delivery
- Immune cells in cancer
- Respiratory viral infections research
- Cancer Cells and Metastasis
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Treatments and Mutations
- Disaster Response and Management
- Occupational exposure and asthma
- Macrophage Migration Inhibitory Factor
- Sympathectomy and Hyperhidrosis Treatments
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Respiratory and Cough-Related Research
Jichi Medical University
2018-2025
Cornell University
2015-2021
Weill Cornell Medicine
2021
Pulmonary and Critical Care Associates
2017
Presbyterian Hospital
2015
New York Hospital Queens
2015
NewYork–Presbyterian Hospital
2015
Tohoku University
2010-2015
The mammalian target of rapamycin complex 1 (mTORC1) regulates activation immune cells and cellular energy metabolism. Although glycolysis has been linked to functions, the mechanisms by which NLRP3 inflammasome remain unclear. Here, we demonstrate that mTORC1-induced provides an essential mechanism for activation. Moreover, hexokinase (HK1)-dependent glycolysis, under regulation mTORC1, represents a critical metabolic pathway Downregulation inhibition Raptor/mTORC1 or HK1 suppressed both...
Mitochondria, vital cellular power plants to generate energy, are involved in immune responses. Mitochondrial damage-associated molecular patterns (DAMPs) molecules that released from mitochondria extracellular space during cell death and include not only proteins but also DNA or lipids. DAMPs induce inflammatory responses critically the pathogenesis of various diseases.Recent studies elucidate mechanisms by which mitochondrial initiate use genetically modulated cells animals. Importantly,...
Sepsis, a life-threatening organ dysfunction caused by dysregulated host response to infection, is major public health concern with high mortality and morbidity. Although inflammatory responses triggered infection are crucial for defense against invading microbes, the excessive inflammation often causes tissue damage leading dysfunction. Resolution of inflammation, an active immune process mediated endogenous lipid mediators (LMs), important maintain homeostasis.We sought determine role...
Abstract Accumulating evidence illustrates a fundamental role for mitochondria in lung alveolar type 2 epithelial cell (AEC2) dysfunction the pathogenesis of idiopathic pulmonary fibrosis. However, mitochondrial fusion AEC2 function and fibrosis development remains unknown. Here we report that absence proteins mitofusin1 (MFN1) mitofusin2 (MFN2) murine cells leads to morbidity mortality associated with spontaneous We uncover crucial MFN1 MFN2 production surfactant lipids regulating synthesis...
Objective Autoantibodies to aminoacyl-tRNA synthetases (ARSs) are useful in the diagnosis of idiopathic inflammatory myopathy (IIM) with interstitial pneumonia (IP). We developed an enzyme-linked immunosorbent assay (ELISA) system using a mixture recombinant ARS antigens and tested its utility multicenter study. Methods: prepared six ARSs: GST-Jo-1, His-PL-12, His-EJ GST-KS expressed Escherichia coli, His-PL-7 His-OJ Hi-5 cells. After confirming their antigenic activity, exception His-OJ, we...
Previous studies suggested an association between upper airway pneumococcal colonization density and pneumonia, but data in children are limited. Using from the Pneumonia Etiology Research for Child Health (PERCH) study, we assessed this potential association. PERCH is a case-control study 7 countries: Bangladesh, The Gambia, Kenya, Mali, South Africa, Thailand, Zambia. Cases were aged 1–59 months hospitalized with World Organization–defined severe or very pneumonia. Controls randomly...
Chronic obstructive pulmonary disease (COPD) is marked by airway inflammation and airspace enlargement (emphysema) leading to airflow obstruction eventual respiratory failure. Microvasculature dysfunction associated with COPD/emphysema. However, it not known if abnormal endothelium drives COPD/emphysema pathology and/or correcting endothelial has therapeutic potential. Here, we show the centrality of cells pathogenesis in human tissue using an elastase-induced murine model emphysema....
The pathogenesis of acute exacerbation idiopathic pulmonary fibrosis (IPF) remains to be elucidated. To evaluate the roles inflammatory mediators in exacerbation, concentrations high mobility group protein B1 (HMGB1), a chief mediator lung injury, and 18 cytokines were measured bronchoalveolar lavage fluid, serially sampled from seven IPF patients after onset exacerbation. HMGB1 gradually increased alveolar fluid positive correlation with monocytes chemotactic protein-1 (MCP-1), potent...
Intestinal ischemia/reperfusion (I/R) injury is a life-threatening complication that leads to inflammation and remote organ damage. The NLRP3 inflammasome regulates the caspase-1-dependent release of IL-1β, an early mediator after I/R injury. In this study, we investigated role in mice with intestinal Deficiency NLRP3, ASC, caspase-1/11, or IL-1β prolonged survival injury, but neither nor caspase-1/11 deficiency affected inflammation. caused acute lung (ALI) characterized by inflammation,...
Sputum examination can be useful in diagnosing the cause of pneumonia adults but is less well established children. We sought to assess diagnostic utility polymerase chain reaction (PCR) for detection respiratory viruses and bacteria induced sputum (IS) specimens from children hospitalized with severe or very pneumonia.Among aged 1-59 months, we compared organism by multiplex PCR IS nasopharyngeal/oropharyngeal (NP/OP) specimens. To whether presence density was associated chest radiographic...
Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease characterized by the excessive accumulation of surfactant proteins within spaces and higher titers autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF) in serum bronchoalveolar lavage fluid. The antibodies inhibit maturation phagocytosis macrophages. Although standard therapy for aPAP has been whole-lung (WLL), this procedure invasive needs be repeated several years. GM-CSF inhalation new treating can...
Background: The lymphatics in the interlobular and subpleural parenchyma contribute to alveolar clearance lung, but information on remodeling of these is quite limited idiopathic pulmonary fibrosis lungs that contain severe regions. We compared alteration lymphangiogenesis among nonfibrotic interstitial pneumonias with a better prognosis. Methods Results: lung tissue specimens eighteen patients (ten surgical biopsies eight autopsies), six organizing pneumonia, cellular nonspecific five...
A 45-year-old woman was hospitalized with severe coronavirus disease 2019 pneumonia. Following cytokine storm-induced multiorgan failure and lethal arrhythmia, the patient developed a sustained coma flaccid quadriplegia. cerebrospinal fluid examination excluded infectious immunogenic encephalopathies, diffusion-weighted magnetic resonance imaging demonstrated high-intensity areas in white matter cortex-sparing distribution, suggesting delayed post-hypoxic leukoencephalopathy. As result of...
TAS-115, a novel oral multi-kinase inhibitor, showed antifibrotic effects in vitro and vivo animal models of idiopathic pulmonary fibrosis (IPF).In this exploratory phase 2 study, IPF patients with percent predicted forced vital capacity (%FVC) decline ≥5% acquired within the previous 6 months were enrolled. Patients divided into three pre-treatment cohorts, namely, treatment-naïve, pirfenidone, or nintedanib. TAS-115 was administered orally at 200 mg/day 5-day on 2-day off regimen. After 13...
The combined pulmonary fibrosis and emphysema (CPFE) was reported first in 1990, but it has been comparatively underestimated until recently. Although the diagnostic findings of both emphysematous fibrotic regions are detectable by high-resolution computed tomography (HRCT) chest, degree progressive fibrosis, which increases with lesions, is difficult to evaluate. In this study, we hypothesized that biomarkers for surfactant protein D (SP-D), KL-6 would serve as good indicators lesions CPFE....
Cancer cells harbor many genetic mutations and gene expression profiles different from normal cells. Patient-derived cancer (PDCC) are preferred materials in study. We established patient-derived spheroids (PDSs) organoids (PDOs) PDCCs isolated the malignant pleural effusion 8 patients. The morphologies suggested that PDSs may be a model of local extensions, while PDOs distant metastases. differed between PDOs: Gene sets related to inflammatory responses EMT were antithetically regulated or...
Both SP-D and KL-6/MUC1 are established biomarkers of the interstitial pneumonias, including idiopathic pulmonary fibrosis (IPF), but causes clinical outcomes based on their independent effects not known. Eleven asymptomatic patients, detected with honeycombing high-resolution computed tomography (HRCT), were compared 17 other IPF outpatients having slight respiratory symptoms as well. Although was increased in both groups, KL-6 significantly higher symptomatic group. When patients...
Background Diffuse pulmonary ossification is a specific lung condition that accompanied by underlying diseases. However, idiopathic dendriform (IDPO) extremely rare, and the clinical features remain unclear. In this study, we aimed to report characteristics of IDPO. Methods We conducted nationwide survey patients with IDPO from 2017 2019 in Japan evaluated clinical, radiological, histopathological findings diagnosed Results Twenty-two cases were identified. Most subjects (82%) male, aged...