A5040961808- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Neutropenia and Cancer Infections
- Fatty Acid Research and Health
- Cardiac Structural Anomalies and Repair
- Pneumocystis jirovecii pneumonia detection and treatment
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Frailty in Older Adults
- Artificial Intelligence in Healthcare and Education
- Advanced Causal Inference Techniques
- Tuberculosis Research and Epidemiology
- Biomarkers in Disease Mechanisms
- AI in cancer detection
- Healthcare cost, quality, practices
- Pleural and Pulmonary Diseases
- Cardiac tumors and thrombi
- Eosinophilic Disorders and Syndromes
- Adrenal Hormones and Disorders
- Clusterin in disease pathology
Mayo Clinic in Arizona
2023-2024
Weill Cornell Medicine
2020-2023
Cornell University
2020-2023
Mayo Clinic
2022
WinnMed
2022
Chronic obstructive pulmonary disease (COPD) is marked by airway inflammation and airspace enlargement (emphysema) leading to airflow obstruction eventual respiratory failure. Microvasculature dysfunction associated with COPD/emphysema. However, it not known if abnormal endothelium drives COPD/emphysema pathology and/or correcting endothelial has therapeutic potential. Here, we show the centrality of cells pathogenesis in human tissue using an elastase-induced murine model emphysema....
Alveolar epithelial type II (AEC2) cells strictly regulate lipid metabolism to maintain surfactant synthesis. Loss of AEC2 cell function and production are implicated in the pathogenesis smoking-related lung disease chronic obstructive pulmonary (COPD). Whether smoking alters synthesis whether altering contributes COPD development unclear. In this study, high-throughput lipidomic analysis revealed increased biosynthesis isolated from mice chronically exposed cigarette smoke (CS). Mice with a...
<h3>Background</h3> Immune checkpoint inhibitor therapy-related (ICI) pneumonitis is a potential serious complication for patients with cancer. We have previously shown that modeling can be used to predict the risk of death from ICI pneumonitis.<sup>1</sup> Further predictive stratify needed. <h3>Methods</h3> A database cancer diagnosed seen at Mayo Clinic 2014–2022 was utilized exploratory data analysis. Within this cohort, we isolated clinical variables before diagnoses determine if could...
1552 Background: Immune checkpoint inhibitor therapy-related (ICI) pneumonitis poses a significant challenge in patients with cancer. There is need for predictive modeling to identify those at high risk of developing serious adverse events ICI pneumonitis. Methods: A newly created database cancer diagnosed seen Mayo Clinic from 2014-2022 was utilized exploratory data analysis. Modeling used determine if three clinical outcomes could be predicted, namely death from: prior starting...
A 57-year-old man with high-grade synovial sarcoma was found to have cardiac involvement of his malignancy. Intracardiac tumor resulted in dynamic left ventricular outflow tract obstruction and severe mitral regurgitation. He underwent valve replacement had no cardiovascular symptoms at 1-year follow-up. (Level Difficulty: Intermediate.).
<h3>Background</h3> Immune checkpoint inhibitor therapy-related (ICI) pneumonitis poses a significant challenge in patients with cancer. There is paucity of data on patient characteristics and outcomes this population. <h3>Methods</h3> This retrospective study diagnosed ICI at the Mayo Clinic from 2014 to 2022. A list was compiled using Clinic's informatics tool, Advanced Text Explorer, keywords 'pneumonitis' 'immunotherapy' (n=848). All cases were independently reviewed by our pulmonology...
OBJECTIVES/GOALS: The host immune response during sepsis is now recognized to have anti-inflammatory pathophysiology. We aim determine whether mitochondrial dysfunction of leukocytes predicts which critically ill septic patients develop paralysis and identify differences in cellular metabolites between with without paralysis. METHODS/STUDY POPULATION: Critically control adult were recruited from one 6 ICUs a single-center tertiary care academic hospital. After enrollment, peripheral blood...