A5040731065- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Colorectal Cancer Treatments and Studies
- Metabolism, Diabetes, and Cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Colorectal Cancer Surgical Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cell Adhesion Molecules Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Nanoplatforms for cancer theranostics
- Cancer, Stress, Anesthesia, and Immune Response
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Adenosine and Purinergic Signaling
- Extracellular vesicles in disease
- Esophageal Cancer Research and Treatment
- Cancer Research and Treatments
Jichi Medical University
2016-2025
Jichi Medical University Hospital
2016-2024
Translational Research Informatics Center (Japan)
2024
The University of Tokyo
2007-2023
University of Tokyo Hospital
2014-2023
National Center for Global Health and Medicine
2023
Osaka International Cancer Institute
2018
Teikyo University
2018
Aichi Cancer Center
2018
Niigata Cancer Center Hospital
2018
Purpose Intraperitoneal paclitaxel plus systemic chemotherapy demonstrated promising clinical effects in patients with gastric cancer peritoneal metastasis. We aimed to verify its superiority over standard overall survival. Patients and Methods This randomized phase III trial enrolled metastasis who had received no or short-term (< 2 months) chemotherapy. were randomly assigned at a two-to-one ratio receive intraperitoneal intravenous S-1 (IP; 20 mg/m 50 on days 1 8 80 per day 14 for...
The CC chemokines regulated on activation normal T expressed and secreted (RANTES) monocyte chemotactic protein 3 (MCP-3), the anaphylatoxin C5a, induce activation, degranulation, chemotaxis, transendothelial migration of eosinophils. Adhesion assays purified ligands showed differential regulation beta 1 2 integrin avidity in Adhesiveness VLA-4 (alpha 4 1, CD29/CD49d) for vascular cell adhesion molecule or fibronectin was rapidly increased but subsequently reduced by RANTES, MCP-3, C5a....
4040 Background: Intraperitoneal (IP) chemotherapy is a promising treatment option for gastric cancer with peritoneal metastasis. We previously reported the safety and efficacy of IP paclitaxel (PTX) plus S-1/PTX in phase I II studies. S-1/oxaliplatin (SOX) showed non-inferiority to S-1/cisplatin PFS, considered as new standard regimen first-line advanced on an outpatient basis Japan. designed combining PTX SOX order maximize systemic effects well local cavity. The recommended dose was...
Adiponectin, a circulating peptide hormone produced in adipose tissue, has been shown to be reduced the plasma of patients with cancer, suggesting that this adipokine may mechanically involved pathogenesis adiposity‐related carcinogenesis. In study, we examined expression adiponectin receptors (AdipoR1 and AdipoR2) assessed function gastric cancer. All six cancer cell lines significantly expressed mRNA protein both variable levels. Addition 30 µg/mL potently induced apoptosis inhibited...
The aim of this study was to assess whether the neutrophil lymphocyte ratio (NLR) and other laboratory markers may predict prognosis advanced colorectal cancer (CRC) patients receiving palliative chemotherapy.The population included 50 with far or recurrent unresectable CRC who received oxaliplatin-based combination chemotherapy as first-line treatment in our hospital between June 2005 November 2010. Seven clinical variables 7 indices before were evaluated retrospectively possible prognostic...
Many types of immune cells appear in peritoneal cavity after abdominal surgery. In patients who underwent laparotomy due to gastric cancer, lavages were obtained before and surgical procedure. Cells recovered from intermediate layer Ficoll-Hypaque centrifugation analyzed for phenotypes functions, especially focused on low density neutrophils (LDN). The number CD66b (+) LDN with mature phenotype was markedly elevated postoperative as compared preoperative lavages. Short term culture the...
Abstract Background Intraperitoneal chemotherapy using paclitaxel is considered an experimental approach for treating peritoneal carcinomatosis. This study aimed to determine the recommended dose, and evaluate clinical efficacy safety, of combination intravenous gemcitabine, nab-paclitaxel intraperitoneal in patients with pancreatic cancer metastasis. Methods The frequencies dose-limiting toxicities were evaluated, dose was determined phase I. primary endpoint II analysis overall survival...
The adhesive interactions of eosinophils with purified E-, P-, and L-selectins; vascular cell adhesion molecule-1 molecule; HUVEC were examined in shear flow. Compared neutrophils, showed markedly less binding to E-selectin, but significantly stronger avidity for P-selectin. Both types a similar level tethering rolling on L-selectin. Eosinophils tethered arrested abruptly molecule-1. However, some the tethers detached within several seconds; this was prevented by stimulation eotaxin. also...
Abnormal hemostasis in cancer patients has previously been described, however the correlation between plasma fibrinogen level and metastasis prognosis not reported a large-scale clinical study. Preoperative levels were retrospectively examined 405 who underwent surgery for advanced gastric cancer. The association of with clinical/pathological findings outcome was evaluated. There positive depth invasion (p < 0.05). Hyperfibrinogenemia (>310 mg/dl) independently associated lymph node (Odds...
<i>Objectives:</i> A dose-escalation study of weekly intraperitoneal paclitaxel (PTX) combined with S-1 and intravenous PTX was performed to determine the maximum-tolerated dose (MTD) recommended (RD) in gastric cancer patients. <i>Patients Methods:</i> Nine patients peritoneal dissemination and/or cells on cytology were enrolled. administered intravenously days 1 8 at a fixed 50 mg/m<sup>2</sup>, intraperitoneally an initial 20 stepped up 30 or 40...
Autophagy is a complex of adaptive cellular response that enhances cancer cell survival in the face stresses such as chemotherapy. Recently, chloroquine diphosphate (CQ), widely used antimalarial drug, has been studied potential inhibitor autophagy. Here, we aimed to investigate role CQ potentiating effect 5-fluorouracil (5-FU), chemotherapeutic agent first choice for treatment colorectal cancer, an animal model colon cancer. The mouse line colon26 was used. For in-vivo study, cells were...
Hyaluronan (HA) is a promising drug carrier for cancer therapy because of its CD44 targeting ability, good biocompatibility, and biodegradability. In this study, cisplatin (CDDP)-incorporating HA nanogels were fabricated through chelating ligand-metal coordination cross-linking reaction. We conjugated ligands, iminodiacetic acid or malonic acid, to used them as precursor polymer. By mixing the ligand-conjugated with CDDP, occurred via ligands platinum in resulting spontaneous formation...
Abstract Background Anti-tumor effects of radiation therapy (RT) largely depend on host immune function. Adenosine with its strong immunosuppressive properties is an important checkpoint molecule. Method We examined how intra-tumoral adenosine levels modify anti-tumor RT in a murine model using anti-CD73 antibody which blocks the rate-limiting enzyme to produce extracellular adenosine. also evaluated CD73 expression irradiated human rectal cancer tissue. Results LuM-1, highly metastatic...
BackgroundLow-density neutrophils (LDN) have been shown to be increased in peripheral blood patients with various diseases and closely related immune-mediated pathology. However, the frequency function of LDN circulating following abdominal surgery not well understood.MethodsLDN were determined by CD66b(+) cells, which copurified mononuclear cells density gradient preparations surgical patients. The effects purified on T cell proliferation tumor lysis examined vitro. Neutrophil extracellular...
Abstract Accumulating evidence suggests that metformin reduces the incidence and mortality of colorectal cancer (CRC). However, underlying mechanisms have not been fully clarified. The aim this study was to examine pathological characteristics resected CRC from patients treated with for type 2 diabetes mellitus (DM). In total, 267 DM underwent curative colectomy Stage I‐III 53 (19.9%) had medically including metformin. Pathological N‐stage significantly lower in metformin‐treated ( P <...
Abstract Background The effectiveness of intraperitoneal chemotherapy using paclitaxel (i.p.‐PTX) in pancreatic ductal adenocarcinoma (PDAC) patients with peritoneal dissemination remains elusive. aim this study is to investigate the clinical outcome treated i.p.‐PTX combined systemic compared current standard including gemcitabine plus nab‐paclitaxel and FOLFIRINOX. Methods Data was retrospectively collected analyzed (i.p.‐PTX, n = 83; control, 86). Inverse probability treatment‐weighted...
Chemokines are widely hypothesized to stimulate firm adhesion of leukocytes on endothelium in shear flow. Thus far, this has been demonstrated experimentally for exogenously added chemoattractants, but not those released by endothelium. We found that human umbilical cord endothelial cells (HUVEC) stimulated with TNF-alpha and IFN-gamma secreted eosinophil chemoattractants into the culture supernatant. This material induced transendothelial chemotaxis, binding purified intercellular molecule...