A5040347472- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Intraperitoneal and Appendiceal Malignancies
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Pulmonary Hypertension Research and Treatments
- Biliary and Gastrointestinal Fistulas
- Cancer Diagnosis and Treatment
- Minimally Invasive Surgical Techniques
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Cardiovascular Issues in Pregnancy
- Aortic aneurysm repair treatments
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
Kansai Medical University
2016-2025
University of Colorado Anschutz Medical Campus
2023
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2022
NIHR Birmingham Biomedical Research Centre
2021
University of Birmingham
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
Satou Hospital
2021
Regulatory T cells (Treg) can inhibit immune responses mediated by cells. The aim of this study was to evaluate the prevalence Treg in peripheral blood mononuclear from patients with pancreatic cancers relation their clinical outcomes.Among a total 100 ductal adenocarcinoma pancreas, 40 underwent pancreatectomy and 60 had unresectable disease. Their were evaluated determine proportion CD4CD25 (FoxP3) cells, as percentage CD4 flow cytometric analysis.The cancer significantly lower than that...
Abstract Background Intraperitoneal chemotherapy using paclitaxel is considered an experimental approach for treating peritoneal carcinomatosis. This study aimed to determine the recommended dose, and evaluate clinical efficacy safety, of combination intravenous gemcitabine, nab-paclitaxel intraperitoneal in patients with pancreatic cancer metastasis. Methods The frequencies dose-limiting toxicities were evaluated, dose was determined phase I. primary endpoint II analysis overall survival...
The aim of current study is to verify usefulness staging laparoscopy (stag-lap) for patient's selection and find prognostic factors in patients with radiographically defined locally advanced (RD-LA) pancreatic ductal adenocarcinoma (PDAC).The LA disease was as an unresectable without distant organ metastasis based on resectability status NCCN guideline this study. Stag-lap performed 67 RD-LA (2007-2012) which were divided into 4 groups according metastatic site: group CY (peritoneal fluid or...
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. For the development of more effective immunotherapies, it is first necessary to elucidate immunological escape mechanisms. In this study, we applied our recently developed highly sensitive immunostaining method employing fluorescent phosphor-integrated dot (PID) nanoparticles evaluate prevalence programmed death ligand 1 (PD-L1) in patients with PDAC.This study included 42 PDAC who underwent pancreatectomy. We evaluated...
Abstract Background Antimicrobial prophylaxis is routinely administered in patients undergoing distal pancreatectomy, with cephalosporins being the most frequently used agents. However, there limited evidence regarding optimal duration of antimicrobial prophylaxis. This study aimed to evaluate pancreatectomy. Methods A multicenter cohort was performed using a common database who underwent pancreatectomy between April 2017 and March 2022 at four high‐volume centers Japan. Eligible were...
Previous retrospective studies have demonstrated the effectiveness of parenchymal pre-compression in reducing pancreatic fistula after left-sided resection; however, no multicentre RCT has been conducted. The aim this study was to investigate whether reduces grade B/C resection. Between 23 March 2021 and 26 January 2023, patients scheduled for resection were enrolled a at 13 hospitals Japan. These randomly assigned (1 : 1) group or non-compression group. primary endpoint incidence secondary...
Abstract Background The effectiveness of intraperitoneal chemotherapy using paclitaxel (i.p.‐PTX) in pancreatic ductal adenocarcinoma (PDAC) patients with peritoneal dissemination remains elusive. aim this study is to investigate the clinical outcome treated i.p.‐PTX combined systemic compared current standard including gemcitabine plus nab‐paclitaxel and FOLFIRINOX. Methods Data was retrospectively collected analyzed (i.p.‐PTX, n = 83; control, 86). Inverse probability treatment‐weighted...
The aims of this study were to verify whether the selective use staging laparoscopy can prevent unnecessary laparotomy and find a surrogate marker for surgical unresectability in patients with potentially or borderline resectable pancreatic cancer.Group A consisted consecutive 33 evaluated between 2005 2006 who directly underwent open planned resection. Group B 61 2007 2009 whom 16 (26%) had due presence high-risk markers defined as carbohydrate antigen 19-9 level 150 U/mL greater tumor size...
Abstract Background Postoperative nonalcoholic fatty liver disease ( NAFLD ) after pancreaticoduodenectomy PD has recently become recognized. However, the pathoetiology of postoperative is largely unknown. Furthermore, optimal treatment not been established. The aim this prospective study was to clarify whether pancrelipase, which contains digestive pancreatic enzymes, could reverse . Methods A collaborative clinical trial conducted UMIN000006841 ). total 30 patients who developed were...
We aimed to identify risk factors for latent distant organ metastasis in patients with radiographically defined locally advanced (RDLA) pancreatic ductal adenocarcinoma (PDAC).RDLA disease was as unresectable without based on resectability status by NCCN guidelines. Between January 2005 and November 2015, 110 consecutive underwent staging laparoscopy rule out metastasis. Univariate multivariate analyses were performed or peritoneal (PM), dissemination and/or positive lavage cytology...
The aim of this study was to investigate the synergistic inhibitory effects gemcitabine and losartan, angiotensin II type 1 (AT1) receptor blockers, on an orthotopic rat pancreatic cancer model.The model prepared using DSL-6A/C cells, a ductal adenocarcinoma cell line. rats were treated with alone (100 mg/kg per week), losartan day), or plus losartan.Survival significantly improved by treatment (89.6 ± 21.8 days) (76.9 18.7 compared that in control group (59.6 13.4 days; P < 0.05). Treatment...
The purpose of the present study was to analyze survival benefit and safety adjuvant surgery in patients with initially unresectable pancreatic cancer following chemo(radio)therapy.The 130 treated during 2006 2013 were divided into a group (15 patients) planned surgery, control (115 locally advanced disease) without surgery.The 15 had shrunken tumor, decreased tumor marker, maintained performance status after 9 months (range 5-18 months) chemo(radio)therapy. Thirteen curative resection two...
Bile leakage after subtotal cholecystectomy (SC) is clinically serious. To prevent such leakage, we developed a new surgical technique in which free piece of omentum plugged into the gallbladder stump (omentum plugging technique). We evaluated whether prevents bile cholecystectomy.Prospectively collected data patients who had undergone without cystic duct closure Department Surgery Kansai Medical University during 12 years from January 2006 to March 2018 were reviewed retrospectively. The...
To examine whether pressure-tight reinforcement of pancreaticojejunostomy (PJ) using polyglycolic acid (PGA) mesh and fibrin glue sealant can reduce the incidence postoperative pancreatic fistula (POPF).The study population included 128 consecutive patients who underwent pancreaticoduodenectomy between September 2006 January 2010. Postoperative mortality morbidity among 50 PJ anastomosis PGA were compared with 78 (historical controls).The 2 groups demonstrated no significant differences in...
After standardization of the perioperative management pancreaticoduodenectomy, we retrospectively compared results in nonstented pancreaticojejunostomy with external-stented pancreaticojejunostomy.The study population included 129 consecutive patients who underwent pancreaticoduodenectomy between 2004 and 2008. The postoperative mortality morbidity were 51 restrictive use external stenting (group A) 78 without B). patient a pancreatic duct less than 3 mm diameter was 31% group A 46% B.There...
Post-operative pancreatic fistula (POPF) is one of the most common and serious complications after pancreaticoduodenectomy (PD). The aim this study to retrospectively compare clinically relevant (CR) POPF other pacreaticojejunostomy (PJ) modified Kakita (m-Kakita) or Blumgart (m-Blumgart) anastomoses without stenting in a single institution. One hundred twenty-eight patients underwent PJ using m-Kakita (two interrupted penetrating sutures) between January 2009 December 2011. eighteen...
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies globally. We have previously explored clinical efficacy of intraperitoneal (IP) paclitaxel therapy for patients with PDAC and peritoneal metastasis, which demonstrated favourable response disease control rates. However, real implications conversion surgery after IP remain unclear.We conducted two multicenter trials in metastasis. focused on who underwent investigated long-term outcomes, particularly, initial...