A5020630499- Pancreatic and Hepatic Oncology Research
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Neuroendocrine Tumor Research Advances
- Cardiac Structural Anomalies and Repair
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- CNS Lymphoma Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Airway Management and Intubation Techniques
- Lymphoma Diagnosis and Treatment
- Burn Injury Management and Outcomes
- COVID-19 Clinical Research Studies
- Cancer, Hypoxia, and Metabolism
- COVID-19 and healthcare impacts
- Antibiotic Use and Resistance
- Restraint-Related Deaths
- Cardiovascular Issues in Pregnancy
- Boron Compounds in Chemistry
- Gastric Cancer Management and Outcomes
- Soft tissue tumor case studies
- COVID-19 diagnosis using AI
- Pediatric Hepatobiliary Diseases and Treatments
Kansai Medical University
2023-2025
Tokyo Metropolitan Tama Medical Center
2022-2024
Keio University
2020-2024
Tenri Hospital
2021-2023
Kumamoto University
2020-2023
Nagasaki University Hospital
2022
Sunagawa City Medical Center
2022
Saiseikai Utsunomiya hospital
2021
Miyazaki Prefectural Hospital
2021
Nagasaki University
2021
Abstract Background The prevalence of extracorporeal cardiopulmonary resuscitation (ECPR) in patients with out-of-hospital cardiac arrest (OHCA) has been increasing rapidly worldwide. However, guidelines or clinical studies do not provide sufficient data on ECPR practice. aim this study was to real-world for OHCA, including details complications. Methods We did a retrospective database analysis observational multicenter cohort Japan. Adult OHCA presumed etiology who received between 2013 and...
Glycolysis is highly enhanced in Pancreatic ductal adenocarcinoma (PDAC) cells; thus, glucose restrictions are imposed on nontumor cells the PDAC tumor microenvironment (TME). However, little known about how such competition alters metabolism and confers phenotypic changes stromal TME. Here, we report that cancer-associated fibroblasts (CAFs) with restricted availability utilize lactate from glycolysis-enhanced cancer as a fuel exert immunosuppressive activity The expression of dehydrogenase...
Coronavirus disease 2019 (COVID-19) has drastically changed everyday life worldwide. This study aimed to determine how COVID-19 affected the characteristics and outcomes of patients with severe burn injury by examining a city-wide database in Tokyo. A descriptive was conducted 14 centers using Tokyo Burn Unit Association registry from 1999 2020. The pandemic started 2020, while stay-at-home order lasted April May. demographics, mechanisms, severity, clinical were assessed before during these...
Abstract Aim The incidence of cholelithiasis after gastrectomy is higher than that in the general population; however, and risk factors for choledocholithiasis have not been well reported. We aimed to assess association between a history choledocholithiasis. Methods A total 3025 patients who underwent cholecystectomy with or without choledocholithotomy January 2006 December 2020 at Kansai Medical University, Japan were included this study. Patients divided into group (173 patients, 5.7%)...
The pulmonary function test (PFT) has played an essential role in diagnosing and managing interstitial lung disease (ILD) but its contraindications difficult conditions to perform. Therefore, the present study aimed evaluate dynamic chest radiography (DCR) ability predict forced vital capacity (FVC) other PFT parameters of ILD patients.The prospective observational included 97 patients who underwent DCR at Tenri Hospital (Tenri, Japan) between June 2019 April 2020. Twenty-five with stable...
Objective Chronic pulmonary aspergillosis (CPA) is an important complication of nontuberculous mycobacterial disease (NTM-PD). However, its diagnosis challenging, as both CPA and NTM-PD present chronic cavitary disease. The study evaluated the impact on survival patients with revealed key computed tomography findings for a prompt diagnosis. Methods We retrospectively reviewed newly diagnosed in Tenri Hospital (Tenri City, Nara Prefecture, Japan) between January 2009 March 2018; were followed...
We report a rare case of negative pressure pulmonary oedema (NPPE), life-threatening complication tracheal intubation. A 41-year-old obese man was admitted to previous hospital for neck surgery. After extubation, he developed respiratory distress followed by haemoptysis and desaturation. The patient reintubated brought our where we introduced venovenous extracorporeal membrane oxygenation (ECMO) prevent cardiac arrest, which is an unusual clinical course NPPE. He returned his routine without...
Chest computed tomography findings are helpful for understanding the pathophysiology of severe acute respiratory distress syndrome (ARDS). However, there is no large, multicenter, chest registry patients requiring veno-venous extracorporeal membrane oxygenation (V-V ECMO). The aim this study was to describe at V-V ECMO initiation and evaluate association between outcomes in ARDS. This retrospective cohort enrolled with ARDS on ECMO, who were admitted intensive care units 24 hospitals Japan...
Sub-phenotyping of acute respiratory distress syndrome (ARDS) could be useful for evaluating the severity ARDS or predicting its responsiveness to given therapeutic strategies, but no studies have yet investigated heterogeneity patients with severe requiring veno-venous extracorporeal membrane oxygenation (V-V ECMO). We conducted this retrospective multicenter observational study in adult treated by V-V ECMO. performed latent class analysis (LCA) identifying sub-phenotypes based on...
Introduction While limiting the tidal volume to 6 mL/kg during veno-venous extracorporeal membrane oxygenation (V-V ECMO) ameliorate lung injury in patients with acute respiratory distress syndrome (ARDS) is widely accepted, best setting for positive end-expiratory pressure (PEEP) still controversial. This study being conducted investigate whether a higher PEEP (15 cmH 2 O) V-V ECMO can decrease duration of support needed severe ARDS, as compared lower setting. Methods and analysis The an...
A considerable number of patients with mild traumatic brain injury have been known to "talk and die." Serial neurological examinations, however, the only method determining necessity repeat computed tomography (CT), no validated has available predict early deterioration minor head injury. This study aimed evaluate association between hypertension bradycardia, a classic sign raised intracranial pressure (Cushing reflex) on hospital arrival determine clinical consequences after blunt trauma....
A 74-year-old man with no overt symptoms was referred for a chest computed tomography (CT) that revealed multiple bilaterally pulmonary ground-glass nodules (GGNs) subtle changes in size over eight months. Surgical lung biopsies were performed the left upper lobe. pathologic study confirmed intravascular large B-cell lymphoma (IVLBCL). This lesion nodule-like cluster of atypical cells, meaning it had been localized several Pulmonary IVLBCL may form focal lesions presenting as GGN on CT and...
BACKGROUND Patients with coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome 2 can rapidly progress to distress (ARDS). Because clinical diagnosis of ARDS includes several diseases, understanding characteristics COVID-19-related is necessary for precise treatment. We report patients due COVID-19-associated pneumonia. CASE REPORT Case 1 involved a 72-year-old Japanese man who presented and fever. Computed tomography (CT) revealed subpleural ground-glass...
Introduction Pump-controlled retrograde trial off (PCRTO) is described as an effective weaning strategy for veno-arterial extracorporeal membrane oxygenation (ECMO) in the guidelines. Contrastingly, there no established veno-arteriovenous (V-AV) ECMO. We report a novel application of PCRTO patient undergoing V-AV Case A 49-year-old man had pneumonia and history kidney transplantation. Two days after intubation, respiratory failure progressed veno-venous (V-V) ECMO was introduced. On day 7...
Although patients who underwent night-time resuscitation for out-of-hospital cardiac arrest (OHCA) had worse clinical outcomes than those day-time resuscitation, the differences between of with OHCA extracorporeal cardiopulmonary (ECPR) in and remain unclear. We analyzed data from Study Advanced Life Support Ventricular Fibrillation Extracorporeal Circulation Japan. Patients were categorized according to whether they received treatment during or night-time. The primary survival hospital...
Abstract Background With recent dramatic developments in chemotherapy, attempts to incorporate surgery into the multidisciplinary treatment of unresectable pancreatic ductal adenocarcinoma with metastasis (UR-M PDAC) have emerged. Maintenance therapy olaparib after chemotherapy including a platinum-based regimen, which inhibits poly ADP-ribose polymerase (PARP) involved DNA repair, was approved for UR-M PDAC positive BRCA mutations. Case presentation A 47-year-old male patient high...