A5041350161- Gastrointestinal disorders and treatments
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Cardiac electrophysiology and arrhythmias
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Pericarditis and Cardiac Tamponade
- Cardiac tumors and thrombi
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Angiogenesis and VEGF in Cancer
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Colorectal Cancer Surgical Treatments
- Pancreatitis Pathology and Treatment
- Immune cells in cancer
- Immunotherapy and Immune Responses
Higashihiroshima Medical Center
2019-2025
Kure Medical Center
2014-2024
National Hospital Organization
2005-2024
Kariya Toyota General Hospital
2021
Tottori University
1999-2019
Thai-Nichi Institute of Technology
2018
Toho University
2015-2017
Kyoto University
2016-2017
Canon (Japan)
2017
Gunma Prefectural Cardiovascular Center
2017
Background Circadian variation in the incidence of acute cardiovascular events is well known but has not been extensively investigated paroxysmal atrial fibrillation, although significance this arrhythmia growing our society with increasing number aged people. Methods and Results We detected 150 patients fibrillation a drug-free state from among 25 500 consecutive Holter recordings. To determine whether onset, maintenance, termination were random events, we analyzed total recorded duration...
Dilated cardiomyopathy (DCM), characterized by dilatation and dysfunction of the left ventricle, is an important cause heart failure. Many mutations in various genes, including cytoskeletal protein genes contractile have been identified DCM patients, but mechanisms how such lead to remain unknown.We established mouse model expressing a mutated cardiac alpha-actin gene, which has reported patients with DCM, (mActin-Tg). mActin-Tg mice showed gradual resulting death The number apoptotic...
Previous retrospective studies have demonstrated the effectiveness of parenchymal pre-compression in reducing pancreatic fistula after left-sided resection; however, no multicentre RCT has been conducted. The aim this study was to investigate whether reduces grade B/C resection. Between 23 March 2021 and 26 January 2023, patients scheduled for resection were enrolled a at 13 hospitals Japan. These randomly assigned (1 : 1) group or non-compression group. primary endpoint incidence secondary...
Atrial fibrillation causes electrophysiological changes of the atrium, thereby facilitating its maintenance. Although expression ion channels is modulated in chronic atrial fibrillation, it yet unknown whether paroxysmal can also lead to electrical remodeling by affecting gene expression.To examine short-term effects rapid pacing on mRNA level voltage-dependent K(+) channels, high-rate was performed Sprague-Dawley rat hearts. Total RNA prepared from appendages 0 8 hours after onset pacing,...
The purposes of this research were 1) to study belief in foreign language learning undergraduate students and 2) investigate satisfaction with using Google classroom submit online homework. findings was at high level homework level.
ACE (angiotensin converting enzyme) gene genotypes have been shown to be a risk factor for development of left ventricular hypertrophy and cardiomyopathy, upon the assumption that DD genotype is linked higher cellular activity leading myocardial fibrosis. To test an analogous hypothesis favors fibrosis in atrium thus promotes atrial fibrillation without any structural heart diseases, we determined distribution 77 patients with lone investigated effects on clinical characteristics...
Esophageal adenoid cystic carcinoma (EACC) is a very rare form of malignant tumor in the esophagus. Here, we report case 78-year-old man who was diagnosed with EACC by preoperative endoscopic biopsy. Thoracoscopy-assisted subtotal esophagectomy lymph node dissection carried out. Microscopic examination resected specimen suggested that invaded to submucosal layer and showed no metastasis. Histologically, primarily exhibited an alveolar solid pattern partial cribriform tubular patterns. Alcian...
Pilsicainide, a class Ic agent, is known to be an effective drug particularly for treating atrial tachyarrhythmias. However, its electrophysiological effects on the atrium have not been well studied. To characterize electrophysiologic of pilsicainide myocytes in drugs, we examined this membrane currents single rabbit using tight-seal whole cell voltage-clamp technique. Under current-clamp condition, did affect action potential duration at therapeutic ranges (_≤_3μM) and slightly shortened it...
Abstract Background Surgical resection of gallbladder cancer with negative margins is the only potentially curative therapy. Most patients are diagnosed in an advanced stage and, despite availability several chemotherapies, prognosis remains dismal. We report a case locally that was successfully treated effective cisplatin plus gemcitabine, followed by resection. Case presentation A 55-year-old Japanese female hospitalized right hypochondrial pain. Enhanced computed tomography revealed 49 ×...
Assessing the health related quality of life (HRQOL) in patients with a disease specific scale is essential. The purpose this study was to develop Japanese version coronary revascularisation outcome questionnaire (CROQ), disease-specific measure HRQOL before and after revascularisation.The English translated into Japanese; some terms were revised, items eliminated suit medical environment. Eight filled out questionnaire, which then analyzed for face validity. In field study, subjects...
Hepatic pseudolymphoma is a very rare benign reactive lymphoid hyperplasia associated with autoimmunity and chronic inflammatory liver diseases such as primary biliary cirrhosis may mimic hepatocellular carcinoma. This diagnosis should be suspected in female suspicious single tumor. Close monitoring needed view of its premalignant nature.
The aim of this study was to evaluate the validity and reliability Seattle Angina Questionnaire, Japanese version (SAQ-J) as a disease-specific health outcome scale in patients with coronary artery disease.Patients disease were recruited from university hospital Tokyo. completed self-administered questionnaires, medical information obtained subjects' records. Face validity, concurrent evaluated using Short Form 36 (SF-36), known group differences, internal consistency, test-retest...
Tumor vasculature is characterized by morphological and functional abnormalities. However, analysis of the dynamics in blood flow still challenging because limited spatial temporal resolution. Synchrotron radiation (SR) microangiography above K-edge iodine contrast agent can provide high-contrast imaging microvessels time orders milliseconds. In this study, mice bearing human breast cancer cell lines MDAMB231 NOTCH4 overexpression (MDAMB231NOTCH4+) normal were assessed using SR...
An 8-year-old spayed female Golden Retriever was referred to us for evaluation of mild lymphocytosis. The peripheral lymphocytes were comprised mostly large granular (LGLs), and flow cytometry showed that they CD3+8+ T lymphocytes. Clonal rearrangement the T-cell receptor gene identified in blood, dog therefore diagnosed with LGL chronic leukemia. subclinical without treatment until hospitalization on day 154, at which point looked like lymphoblasts surface markers changed CD3-8-. This...
Key Clinical Message Inferior vena cava (IVC) aneurysms are extremely rare. Patients can be asymptomatic, have thrombosis, rupture, or pulmonary embolism. Thrombosis of the IVC aneurysm may mimic a retroperitoneal tumor. Surgical treatment abdominal venous with thrombosis is warranted and necessary for management intraoperative bleeding thrombosis.
[b]BACKGROUND[/b] Malignant tumors, such as lung and breast cancers, can metastasize to the heart. However, cardiac metastasis rarely occurs in colorectal cancer. Cardiac cases are typically asymptomatic cause tamponade. Heart failure due systemic is a terminal symptom; therefore, diagnosed when patient alive. We report case of stage II ascending colon cancer with tamponade pericardial metastasis. [b]CASE REPORT[/b] The was 63-year-old woman who underwent laparoscopic ileocecal resection for...
Convulsion in diabetics is often considered as a result from fluctuation of blood glucose level. However, if diabetic patient also presents abnormal neurological signs, mitochondrial diseases need to be the differential diagnosis.
Abstract Background Duodenal gastrointestinal stromal tumors are rare. If tumor growth is extraluminal and involves the head of pancreas, diagnosis a duodenal difficult. Case presentation A 44-year-old Japanese woman was referred to our hospital with anemia. An enhanced computed tomography scan showed hypervascular mass 30 mm in diameter, but origin tumor, either duodenum or unclear. Upper endoscopy revealed bulging accompanied by erosion redness part bulb. Mucosal biopsy not diagnostic....
<title>Abstract</title> <bold>Background and aims</bold> There is no current consensus regarding the best practices for techniques devices in laparoscopic hepatic parenchymal transection.<bold> </bold>To compare safety, efficacy, outcomes between coagulation non-coagulation while using clamp-crush technique modern transections. <bold>Methods</bold> The clinical of patients who underwent liver resection hepatocellular carcinoma metastasis by with a Biclamp (n=74) Harmonic ACE (n=92),...