A5083613461- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Abdominal Trauma and Injuries
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Surgical Treatments
- Cancer-related gene regulation
- DNA Repair Mechanisms
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Microtubule and mitosis dynamics
- Renal cell carcinoma treatment
Sakai Municipal Hospital
2021-2025
Osaka National Hospital
2025
Ebara (Japan)
2024
Doshisha University
2024
Kyushu University Beppu Hospital
2018-2023
Osaka University
2017-2023
Kyushu University Hospital
2022
Kyoto University
2022
Osaka City General Hospital
2015-2018
Osaka Prefectural Medical Center
2015-2018
Abstract Background The increasing incidence of gastric cancer in the elderly underscores need for an in-depth understanding challenges and risks associated with surgical interventions this demographic. This study aims to investigate risk factors prognostic indicators non-cancer-related mortality following curative surgery patients. Methods retrospective analysis examined 684 patients pathological Stage I—III who underwent resection between January 2012 December 2021. focused on aged 70...
Sclerosing angiomatoid nodular transformation (SANT) is a rare, benign lesion of the spleen. Preoperative diagnosis SANT without pathological examination poses significant challenges, particularly in patients with previous history malignancy. The present study describes case 53-year-old woman that presented to our institution general fatigue and anemia. Based on rectal cancer, patient underwent curative surgery. Postoperatively, minor leakage need for endoluminal drainage, was monitored...
Targeting mutated oncogenes is an effective approach for treating cancer. The 4 main driver genes of pancreatic ductal adenocarcinoma (PDAC) are KRAS, TP53, CDKN2A, and SMAD4, collectively called the "big 4" PDAC, however they remain challenging therapeutic targets. In this study, ArfGAP with SH3 domain, ankyrin repeat PH domain 2 (ASAP2), one family, was identified as a novel gene in PDAC. Clinical analysis PDAC datasets showed that ASAP2 overexpressed cells based on increased DNA copy...
Abstract Background Driver alterations may represent novel candidates for driver gene-guided therapy; however, intrahepatic cholangiocarcinoma (ICC) with multiple genomic aberrations makes them intractable. Therefore, the pathogenesis and metabolic changes of ICC need to be understood develop new treatment strategies. We aimed unravel evolution identify ICC-specific characteristics investigate pathway associated development using multiregional sampling encompass intra- inter-tumoral...
Abstract Cervical cancer (CC) is usually initiated by infection with high‐risk types of human papillomavirus (HPV). The HPV E6 and E7 proteins target p53 RB, respectively, but other cellular targets likely exist. We generated uterus‐specific MOB1A/B double KO (u Mob1 DKO) mice, which immediately developed cervical squamous cell carcinoma in situ. Mutant epithelial cells showed YAP1‐dependent hyperproliferation, altered self‐renewal, impaired contact inhibition, chromosomal instability....
Abstract Microtubules are among the most successful targets for anticancer therapy because they play important roles in cell proliferation as constitute mitotic spindle, which is critical chromosome segregation during mitosis. Hence, identifying new therapeutic encoding proteins that regulate microtubule assembly and function specifically cancer cells critical. In present study, we identified a candidate gene promotes tumor progression, ribonucleic acid export 1 ( RAE1 ), checkpoint...
Abstract Gastric cancer (GC) is one of the most lethal malignant tumors. To improve prognosis GC, identification novel driver genes as therapeutic targets in urgent need. Here, we aimed to identify and clarify their roles gastric cancer. OSBPL3 was identified a candidate gene by silico analysis public genomic datasets. expression analyzed RT-qPCR immunohistochemistry GC cells tissues. The biological functions mechanisms were examined vitro vivo using cells. association between clinical...
Abstract Background As the prevalence of gastric cancer rises in aging populations, managing surgical risks and comorbidities elderly patients presents a unique challenge. The Comprehensive Preoperative Assessment Support (CPAS) program, through comprehensive preoperative assessments, aims to mitigate stress improve outcomes by enhancing patient awareness preparation. This study investigates efficacy CPAS incorporating frailty sarcopenia evaluations, short-term patients. Methods A...
Kinesin family member 15 (KIF15) participates in the transport of macromolecules essential cellular processes. In this study we evaluated clinical relevance KIF15 expression hepatocellular carcinoma (HCC).Association between and outcomes HCC patients was analyzed using three independent cohorts. Localization assessed by immunohistochemical analysis. Co-culture experiments were performed healthy donor peripheral blood mononuclear cells (PBMC) cell lines.Immunohistochemical analysis showed...
Background/Aim: Peritoneal dissemination (PD) occurs frequently in gastric cancer (GC) and is fatal. The interactions between tumor cells stromal are critical for progression. Our aim was to identify a novel PD-associated gene derived from GC. Materials Methods: Among the candidate genes identified our previous study, we focused on spondin-2 (SPON2), an extracellular matrix-secreted protein. Clinicopathological prognostic analyses of SPON2 mRNA expression were performed using GC datasets....
Rheumatoid synovial cells are resistant to apoptosis induction in vivo, whereas, fibroblast-like rheumatoid arthritis (RA-FLS) vulnerable Fas-induced vitro.To clarify this discrepancy by studying the contribution of interaction between cellular integrin and matrix fibronectin (Fn), which is significantly increased joints, RA-FLS.Integrin Fas mRNAs were measured reverse transcription-polymerase chain reaction RA-FLS. Integrins expressed tissues analysed immunohistochemistry. RA-FLS plated...
Ceftriaxone is a widely used third-generation cephalosporin showing advantageous pharmacokinetic properties and broad antimicrobial spectrum. We herein report case of ceftriaxone-induced neurotoxicity in 56-year-old man on hemodialysis. Seven days after initiating high-dose ceftriaxone, the patient developed impaired consciousness along with facial myoclonus sporadic phonation. The symptoms clearly disappeared shortly withdrawal drug. considered safe antibiotic for patients renal...
A Darwinian evolutionary shift occurs early in the neutral evolution of advanced colorectal carcinoma (CRC), and copy number aberrations (CNA) are essential transition from adenoma to carcinoma. In light this primary evolution, we investigated principles genome that foster postoperative recurrence CRC. CNA neoantigens (NAG) were compared between tumors with (CRCR) without (precancerous early; PCRC). We CNA, single nucleotide variance (SNV), RNA sequences, T-cell receptor (TCR) repertoire 9...
Background/Aim: Programmed death-ligand 1 (PD-L1/CD274) elicits T-cell anergy, leading to immune suppression. We aimed determine the prognostic relevance of PD-L1 expression in blood breast cancer (BC) patients. Materials and Methods: measured mRNA tumor tissues BC patients using RT-qPCR a dataset from The Cancer Genome Atlas, performed survival analysis 330 Flow cytometric was cells. Results: No statistical difference seen between normal controls or tissues. There significant positive...
Fanconi anemia complementation group E (FANCE) is a (FA) pathway gene that regulates DNA repair. We evaluated the clinical relevance of FANCE expression in hepatocellular carcinoma (HCC).First, associations between FA genes including and outcomes HCC patients were analyzed 2 independent cohorts: The Cancer Genome Atlas (TCGA, n = 373) our patient cohort (n 53). Localization tissues was observed by immunohistochemical staining. Gene set enrichment analysis (GSEA) network (SiGN_BN) conducted...