A5069185090- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Cervical Cancer and HPV Research
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Wnt/β-catenin signaling in development and cancer
- Vasculitis and related conditions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ubiquitin and proteasome pathways
- Parkinson's Disease and Spinal Disorders
- Galectins and Cancer Biology
- Biomarkers in Disease Mechanisms
- Nutrition and Health in Aging
- Atrial Fibrillation Management and Outcomes
- Neurological and metabolic disorders
- Genomics and Chromatin Dynamics
- Circular RNAs in diseases
- Adenosine and Purinergic Signaling
- Peptidase Inhibition and Analysis
- Cancer Risks and Factors
- RNA Research and Splicing
Kyushu University Beppu Hospital
2018-2023
Kyushu University
2013-2021
Ehime University
2019
Koga Hospital
2017
Abstract Alternative splicing, regulated by DEAD ‐Box Helicase ( DDX ) families, plays an important role in cancer. However, the relationship between family and cancer has not been fully elucidated. In present study, we identified a candidate oncogene 56 on Ch.7p bioinformatics approach using The Cancer Genome Atlas TCGA dataset of colorectal CRC ). expression was measured RT ‐ qPCR immunochemical staining 108 patients. Clinicopathological survival analyses were carried out three datasets....
Abstract Background Driver alterations may represent novel candidates for driver gene-guided therapy; however, intrahepatic cholangiocarcinoma (ICC) with multiple genomic aberrations makes them intractable. Therefore, the pathogenesis and metabolic changes of ICC need to be understood develop new treatment strategies. We aimed unravel evolution identify ICC-specific characteristics investigate pathway associated development using multiregional sampling encompass intra- inter-tumoral...
Targeting mutated oncogenes is an effective approach for treating cancer. The 4 main driver genes of pancreatic ductal adenocarcinoma (PDAC) are KRAS, TP53, CDKN2A, and SMAD4, collectively called the "big 4" PDAC, however they remain challenging therapeutic targets. In this study, ArfGAP with SH3 domain, ankyrin repeat PH domain 2 (ASAP2), one family, was identified as a novel gene in PDAC. Clinical analysis PDAC datasets showed that ASAP2 overexpressed cells based on increased DNA copy...
Abstract Microtubules are among the most successful targets for anticancer therapy because they play important roles in cell proliferation as constitute mitotic spindle, which is critical chromosome segregation during mitosis. Hence, identifying new therapeutic encoding proteins that regulate microtubule assembly and function specifically cancer cells critical. In present study, we identified a candidate gene promotes tumor progression, ribonucleic acid export 1 ( RAE1 ), checkpoint...
Abstract Gastric cancer (GC) is one of the most lethal malignant tumors. To improve prognosis GC, identification novel driver genes as therapeutic targets in urgent need. Here, we aimed to identify and clarify their roles gastric cancer. OSBPL3 was identified a candidate gene by silico analysis public genomic datasets. expression analyzed RT-qPCR immunohistochemistry GC cells tissues. The biological functions mechanisms were examined vitro vivo using cells. association between clinical...
Kinesin family member 15 (KIF15) participates in the transport of macromolecules essential cellular processes. In this study we evaluated clinical relevance KIF15 expression hepatocellular carcinoma (HCC).Association between and outcomes HCC patients was analyzed using three independent cohorts. Localization assessed by immunohistochemical analysis. Co-culture experiments were performed healthy donor peripheral blood mononuclear cells (PBMC) cell lines.Immunohistochemical analysis showed...
Background/Aim: Peritoneal dissemination (PD) occurs frequently in gastric cancer (GC) and is fatal. The interactions between tumor cells stromal are critical for progression. Our aim was to identify a novel PD-associated gene derived from GC. Materials Methods: Among the candidate genes identified our previous study, we focused on spondin-2 (SPON2), an extracellular matrix-secreted protein. Clinicopathological prognostic analyses of SPON2 mRNA expression were performed using GC datasets....
Colorectal cancer (CRC) is one of the most common types and a significant cause mortality worldwide. Further improvements CRC therapeutic approaches are needed. BCL2-associated athanogene 6 (BAG6), multifunctional scaffold protein, plays an important role in tumor progression. However, regulation BAG6 malignancies remains unclear. This study showed that guided entry tail-anchored proteins factor 4 (GET4), component complex, regulates intercellular localization CRC. Furthermore, GET4 was...
There is growing evidence that patients with metastatic breast cancer whose disease progresses from a new metastasis (NM) have worse prognosis than of pre-existing metastasis. The aim this pilot study to identify blood biomarker predicting NM in cancer. expression epithelial (cytokeratin 18/19) or mesenchymal (plastin-3, vimentin, and N-cadherin) markers the peripheral (PB) recurrent undergoing chemotherapy eribulin S-1 was measured over course treatment by RT-qPCR. clinical significance...
Background/Aim: Programmed death-ligand 1 (PD-L1/CD274) elicits T-cell anergy, leading to immune suppression. We aimed determine the prognostic relevance of PD-L1 expression in blood breast cancer (BC) patients. Materials and Methods: measured mRNA tumor tissues BC patients using RT-qPCR a dataset from The Cancer Genome Atlas, performed survival analysis 330 Flow cytometric was cells. Results: No statistical difference seen between normal controls or tissues. There significant positive...
Abstract Background: Gastric cancer is one of the most common forms worldwide. The progression chronic atrophic gastritis (CAG) involved in gastric carcinogenesis. With gastritis, risk increased a stepwise fashion. Non-invasive tools for early are required to improve prognosis. MicroRNAs (miRNAs), class small non-coding RNAs 19-22 nucleotides length, function as post-transcriptional regulators by directly cleaving target messenger RNA or translational repression. MiRNAs serum have been shown...
Abstract Background: Colorectal cancer (CRC) is one of the most common cancers worldwide and second leading cause cancer-related deaths in developed countries, with majority being attributed to distant metastasis. Therefore, it necessary identify a novel biomarker for progression metastasis, that could also be useful therapeutic target CRC. Amplification chromosome 7p frequent CRC, has been considered harbor driver genes promote tumorigenesis or tumor by gain function. We aimed candidate on...
Abstract Introduction: Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with extremely poor overall survival. There no available molecular marker in clinical application until now. SATB1(special AT-rich binding protein 1) tether genomic DNA nucleolus and hold three-dimensional structure of DNA. We evaluated SATB1 expression using samples from patients ESCC analyzed the association clinicopathological factors prognosis to identify novel prognostic ESCC. In addition,...
Background: Pancreatic cancer (PC) is the most lethal in humans, with a 5-year survival rate of less than 10%. Thus, identification prognostic biomarkers as well molecular therapeutic targets should be critical.Translational reprogramming has been attracting attention. Several studies have reported that genomic alternations translational regulatory gene contributing to malignancy. eIF5-mimic protein 1 (5MP1), previously termed BZW2 member bZIP superfamily transcription factors. 5MP1...
Abstract Background/Introduction Long-term efficacy following catheter ablation (CA) of atrial fibrillation (AF) remains unknown. Left (LA) reverse remodeling CA may be important to reduce the risk very late recurrence (VLR). Purpose We hypothesize that improved mechanical conduction delay with myocardial strain is associated LA indicates AF ablation. This study aimed investigate clinical utility predict VLR in patients undergoing CA. Methods enrolled 114 consecutive initial from January...