A5103020921- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Gastrointestinal disorders and treatments
- Tuberculosis Research and Epidemiology
- Gastrointestinal Tumor Research and Treatment
- Mycobacterium research and diagnosis
- Cardiovascular Effects of Exercise
- Esophageal and GI Pathology
- Cardiac Structural Anomalies and Repair
- ECG Monitoring and Analysis
- Cardiac Valve Diseases and Treatments
- Diagnosis and treatment of tuberculosis
- Cardiovascular Health and Disease Prevention
- Advanced MRI Techniques and Applications
- Helicobacter pylori-related gastroenterology studies
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Gastric Cancer Management and Outcomes
- Cardiovascular Disease and Adiposity
Yamagata University
2022-2024
Ehime University
2015-2024
Tsurumi University
2003-2023
Osaka Prefectural Medical Center
2005-2021
Pulmonary Hypertension Association
2016
Meijo Hospital
2011
National Cerebral and Cardiovascular Center
2005-2010
Dokkyo Medical University Saitama Medical Center
2008-2010
Oita University
2010
Dokkyo University
2008
This study is a pharmacogenetic clinical trial designed to clarify whether the N-acetyltransferase 2 gene (NAT2) genotype-guided dosing of isoniazid improves tolerability and efficacy 6-month four-drug standard regimen for newly diagnosed pulmonary tuberculosis.In multicenter, parallel, randomized, controlled with PROBE design, patients were assigned either conventional treatment (STD-treatment: approx. 5 mg/kg all) or NAT2 (PGx-treatment: 7.5 homozygous 4: rapid acetylators; mg/kg,...
Reports of spontaneous dissection the superior mesenteric artery are rare. Diagnosis in acute stage has been considered difficult, but we encountered four cases from November 1998 to 2001. All were diagnosed using abdominal CT scanning and could be treated conservatively. patients provided anticoagulation therapy upon fasting. The mean period continuous pain was 10.2 days, fasting 27.2 number in-hospital days 44.5. There is no established opinion on treatment, conservative treatment possible...
Genetic abnormalities specific to post-H. pylori eradication gastric cancer (GC), especially those associated with undifferentiated post-eradication GC, are unknown. We conducted next-generation sequencing of GC diagnosed either before or after investigate the carcinogenesis GC. Five cases differentiated [HP(-)-D group], five H. pylori-positive [HP(+)-D four [HP(-)-U group)], and six [HP(+)-U group)] underwent analysis. DNA was extracted from tumor samples, non-tumor samples all subjects....
<h3>Background</h3> Desbuquois dysplasia (DD) is a recessively inherited condition characterised by short stature, generalised skeletal and advanced bone maturation. DD both clinically radiographically heterogeneous, two subtypes have been distinguished based on the presence (type 1) or absence 2) of an accessory metacarpal bone. In addition, apparently distinct variant without additional but with metacarpals long phalanges (Kim variant) has described recently. Mutations in gene that encodes...
Background:Fractional flow reserve (FFR) is widely used for the assessment of myocardial ischemia. Intravascular ultrasound (IVUS) an intracoronary imaging method that provides information about lumen and vessel morphology. Previous studies on expanded use IVUS to identify functional ischemia have noted association between anatomy physiology, but IVUS-derived minimum area (MLA) has a weak-moderate correlation with compared FFR. We developed calculate FFR using anatomical The aims this study...
Background and Study Aims: Complete resection of small carcinoid tumors the rectum is difficult during endoscopic polypectomy, because these are often located in submucosal layer rectal wall. To completely remove tumors, we have used aspiration lumpectomy. In this study, evaluated its clinical usefulness comparison with strip biopsy. Patients Methods: We performed biopsy (December 1996 through March 2000) or lumpectomy (April 2000 February 2003) a consecutive series patients tumor. Eight...
Hypertrophic cardiomyopathy (HCM) impairs left ventricular (LV) diastolic function leading to atrial (LA) dilatation. Because Doppler echocardiography cannot accurately assess LV in hearts with heterogeneous hypertrophy, assessment of LA might be useful for risk stratification patients HCM. This study aimed elucidate the impact on outcome patients.Seventy-six HCM who underwent echocardiographic and cardiac magnetic resonance imaging were retrospectively enrolled. Twenty-six control subjects...
In our previous study, colorectal cancer (CRC) patients with active Mycobacterium tuberculosis (MTB) tolerated concurrent anti-cancer chemotherapy (anti-CCT) and anti-MTB chemotherapy. this we retrospectively confirmed the efficacy safety of in a greater number different types malignancies.We enrolled 30 who were treated concurrently anti-CCT regimens between January 2006 February 2016. Cancer MTB treatments administered according to approved guidelines.Patient demographics included:...
Abstract Purpose To evaluate left atrial (LA) function in patients with hypertrophic cardiomyopathy (HCM) by LA strain assessment using cardiac computed tomography (CT-derived strain). Materials and methods This was a retrospective study of 34 HCM 31 non-HCM who underwent (CT) electrocardiogram-gated mode. CT images were reconstructed every 5% (0–95%) the RR intervals. CT-derived (reservoir [LASr], conduit [LASc], booster pump [LASp]) semi-automatically analyzed dedicated workstation. We...
Abstract Background Tuberculosis (TB) is a major public health problem. The Airin district of Osaka City has large population homeless persons and caregivers estimated to be the largest TB-endemic area in intermediate-prevalence country, Japan. However, there have been few studies caregivers. objective this study detect active TB assess prevalence risk factors for latent infection among Methods We conducted cross-sectional screening (active infections) using questionnaire, chest X-ray (CXR),...
The pathological process of left ventricular (LV) hypertrophy is associated with atrial (LA) remodeling. This study was aimed to evaluate the prognostic value LA strain parameters in patients LV hypertrophy.This included 95 hypertensive heart disease (HHD: n = 24), hypertrophic cardiomyopathy (HCM: 56), cardiac amyloidosis (CA: 15), and control subjects (n 20). We used two-dimensional speckle tracking echocardiography (STE) analyze global strain. electromechanical conduction time (EMT) at...
Protocols on the use of novel oral anticoagulants for stroke prevention in patients with atrial fibrillation (AF) undergoing electrical cardioversion (ECV) are lacking.The study was aimed at evaluating efficacy dabigatran (Dabi) treatment preventing peri-ECV stroke.A retrospective survey incidence and fate left (LA) thrombus during Dabi therapy AF conducted between December 2012 January 2013 by Japanese Heart Rhythm Society.A total 198 from 299 institutions underwent transesophageal...
Lanthanum carbonate (LaC) is used to prevent hyperphosphatemia in dialysis patients. It commonly believed that there little LaC absorption from the intestines. However, La deposition gastric mucosa, which we coined “gastric lanthanosis”, was recently reported. We describe here clinicopathological features of and a possible mechanism for lanthanosis. This study included 23 patients with definite extracted characteristic lanthanosis by computed tomography (CT) imaging endoscopic, histologic,...
Background: Although high defibrillation threshold (DFT) is a major and unavoidable clinical problem after implantation of an implantable cardioverter defibrillator (ICD), little known about the cause management DFT in patients with hypertrophic cardiomyopathy (HCM). The purpose this study was to assess predictors HCM. Methods Results: Twenty-three non-dilated HCM who underwent ICD were included. at time device measured all patients. divided into 2 groups, group (DFT ≥15J, n=13) low <15J,...
Abstract Although genomic copy number aberrations (CNAs) of gastric carcinoma at the advanced stage have already been extensively characterized by array comparative hybridization (array CGH) analysis, those in situ (CIS) are still poorly understood. Furthermore, no reports demonstrated correlations between CNAs and histopathological features adenoma. In this study, we investigated 20 CISs (Vienna category 4.2) adenomas including seven low‐grade (LGA; Vienna 3) 13 high‐grade (HGA; 4.1), using...
Background and Aim: Tocilizumab, a humanized anti-IL-6 receptor antibody, has been used to treat severely critically ill patients with COVID-19. A living systematic review meta-analysis of recent RCTs indicates that the combination therapy corticosteroids tocilizumab produce better outcomes, while previous observational studies suggest monotherapy is beneficial for substantial numbers patients. However, what could respond remained unknown. Methods: In this retrospective study we evaluated...
Background It was recently suggested that the angiotensin-converting enzyme insertion/insertion genotype, which is considered to be protective against cardiovascular disease, a significant risk factor for atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM). The aim of this study investigate association between endothelin-2 (EDN2) A985G polymorphism and AF HCM. Methods Results EDN2 (rs 5800) genotyped 110 HCM who had no clinically documented before medical treatment....
Angiotensin II is involved in the genesis of atherosclerosis. As role angiotensin type 1a (AT(1a)) receptor plaque rupture poorly understood, we assessed hypothesis that AT(1a)receptor contributes to atherosclerotic rupture.Atherosclerotic was induced by carotid artery ligation for 4 weeks followed polyethylene cuff placement around apolipoprotein E (ApoE)(-/-) and ApoE(-/-) AT(1a)(-/-) mice. The incidence at days after 72% mice compared with 24% (P<0.01). Lipid accumulation, macrophage...