A5112362020- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Mycology
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Quinazolinone synthesis and applications
- COVID-19 Clinical Research Studies
- Tracheal and airway disorders
- Long-Term Effects of COVID-19
- Actinomycetales infections and treatment
- Medical Imaging and Pathology Studies
- Hematological disorders and diagnostics
- COVID-19 diagnosis using AI
- Pharmacological Effects of Natural Compounds
- Pleural and Pulmonary Diseases
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Helicobacter pylori-related gastroenterology studies
- Vascular Anomalies and Treatments
- Lung Cancer Treatments and Mutations
- Ginseng Biological Effects and Applications
- Respiratory and Cough-Related Research
- Sarcoidosis and Beryllium Toxicity Research
National Kinki Chuo Hospital for Chest Disease
2016-2025
Second Affiliated Hospital of Nanjing Medical University
2019
Nagasaki University
2018
Fukuyama University
2018
Japan Anti Tuberculosis Association
2013
Fukujuji Hospital
2013
Tokyo National Hospital
2013
Office of Infectious Diseases
2012
Clinical Research Management
2007
Kyoto University
1997-2002
The tuberculin skin test for immunologic diagnosis of Mycobacterium tuberculosis infection has many limitations, including being confounded by bacillus Calmette-Guérin (BCG) vaccination or exposure to nontuberculous mycobacteria. M. tuberculosis–specific antigens that are absent from BCG and most mycobacteria have been identified. We examined the use two these antigens, CFP-10 ESAT-6, in a whole blood IFN-γ assay as diagnostic BCG-vaccinated individuals. Because lack an accurate standard...
This study is a pharmacogenetic clinical trial designed to clarify whether the N-acetyltransferase 2 gene (NAT2) genotype-guided dosing of isoniazid improves tolerability and efficacy 6-month four-drug standard regimen for newly diagnosed pulmonary tuberculosis.In multicenter, parallel, randomized, controlled with PROBE design, patients were assigned either conventional treatment (STD-treatment: approx. 5 mg/kg all) or NAT2 (PGx-treatment: 7.5 homozygous 4: rapid acetylators; mg/kg,...
In recent years, many novel nontuberculous mycobacterial species have been discovered through genetic analysis. Mycobacterium massiliense and M. bolletii recently identified as separate from abscessus. However, little is known regarding their clinical microbiological differences in Japan. We performed a molecular identification of stored abscessus isolates for further identification. compared characteristics, radiological findings, treatment outcomes among patients with lung diseases. An...
We have investigated the efficacy of a clarithromycin-containing four-drug regimen for Mycobacterium avium complex (MAC) pulmonary disease in 46 patients without acquired immunodeficiency syndrome (AIDS). The were 14 males and 32 females with mean age 60.9 ± 11.5 yr. Patients received 10 mg/kg/d clarithromycin plus ethambutol, rifampin, initial kanamycin subsequent quinolone 24 mo. Seven (15.2%) dropped first 6 Among 39 who more than mo therapy, 28 (71.8%) converted their sputa to negative:...
Chest computed tomography (CT) is effective for assessing the severity of coronavirus disease 2019 (COVID-19). However, clinical factors reflecting progression COVID-19 pneumonia on chest CT and predicting a subsequent exacerbation remain controversial. We conducted retrospective cohort study 450 patients. used an automated image processing tool to quantify lesion extent at admission. The associated with were estimated by multiple regression analysis. After adjusting background propensity...
Pulmonary nocardiosis is a rare but severe infection caused by Nocardia species. This study aimed at describing the clinical characteristics and prognosis of pulmonary nocardiosis.An observational, retrospective was undertaken patients diagnosed with over 13-year period Kinki-Chuo Chest Medical Center, Osaka, Japan.Seven airway nocardial colonization 59 were identified, one whom had disseminated nocardiosis. Patients predominantly male (73%), mean age 66 (range, 15-88) years. New-onset cough...
Amikacin liposome inhalation suspension (ALIS) is key for treating refractory Mycobacterium avium complex pulmonary disease (MAC-PD). However, microbiological efficacy by subtype remains unknown. The frequency and mechanism of amikacin (AMK) resistance during ALIS administration are also unclear. We retrospectively analyzed data from MAC-PD patients who received at least 6 months as an adjunct to guideline-based therapy the NHO Kinki Chuo Chest Medical Center. investigated gene expression...
Rationale: Patients with noncavitary nodular bronchiectatic (NB) Mycobacterium avium complex pulmonary disease (MAC-PD) are treated intermittently three times a week, although no randomized controlled trials have been conducted comparing weekly to daily therapy. Objectives: To assess the tolerability, safety, and efficacy of intermittent versus treatment in patients previously untreated NB MAC-PD Methods: In an open-label study, were randomly assigned therapy group receiving clarithromycin...
We report two Japanese families affected by pulmonary Mycobacterium avium complex (MAC) disease, involving an older brother and younger sister in one family brothers the second family. investigated whether defects natural resistance-associated macrophage protein gene (NRAMP1) underlay susceptibility to MAC these cases. All of patients had computed tomographic findings peripheral nodules bronchiectasis. Pulse-field gel electrophoresis patterns mycobacterial genomic DNA restriction fragments...
CONVERT, a randomized, active-controlled, global, Phase 3 trial demonstrated that patients with treatment-refractory Mycobacterium avium complex (MAC) pulmonary disease were more likely to achieve culture conversion amikacin liposome inhalation suspension (ALIS) plus guideline-based therapy (GBT) versus those continuing on GBT alone. This subgroup analysis reports the efficacy and safety of ALIS in Japanese enrolled CONVERT. aged ≥20 years MAC from sites included. Patients randomized receive...
Abstract In 2016, disseminated tuberculosis caused by Mycobacterium caprae was diagnosed in a captive Borneo elephant Japan. The bacterium initially identified from clinical isolates. An isolate collected during relapse showed isoniazid monoresistance and codon 315 katG mutation.
Objective The incidence and clinical importance of delirium in coronavirus disease 2019 (COVID-19) have not yet been fully investigated. present study reported the prevalence patients with COVID-19 identified factors associated mortality. Methods We performed an observational, retrospective diagnosed at Kinki-Chuo Chest Medical Center. Univariate multivariate logistic regression analyses were used to explore risk factors. Patients All consecutive Results 600 [median age: 61.0 (interquartile...
Nivolumab has become the standard second-line chemotherapy for non-small cell lung cancer. A 73-year-old man with stage IV cancer received 6 cycles of nab-paclitaxel/carboplatin/bevacizumab followed by 11 nab-paclitaxel/bevacizumab; however, treatment was stopped due to pneumothorax. One year after therapy started, a nodule appeared in left upper and increased size. Mycobacterium abscessus subsp. massiliense disease diagnosed sputum analysis. After short antibiotic treatment, nivolumab...
Mycobacterium abscessus complex is a significant pathogen in patients with non-cystic fibrosis (non-CF). Nevertheless, there little description of the genetic diversity this species. The aims study were to investigate distribution M. isolated from respiratory specimens by variable number tandem repeat (VNTR) typing. results 104 clinical isolates non-CF compared using PFGE, hsp65 genotypes and clarithromycin susceptibility. allelic (Hunter-Gaston Discriminatory Index) 17 loci examined VNTR...
Abstract Background Advances in anticancer drugs for lung cancer (LC) have improved the prognosis of LC. Chronic pulmonary aspergillosis (CPA) is a progressive and often exacerbating respiratory disease with poor prognosis. To date, LC complicated by CPA has not been elucidated. This study investigated clinical implications concomitant patients undergoing drug treatment. Methods Between January 2010 May 2020, we consecutively enrolled at five different institutions Japan. We analyzed who...