A5051237437- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- Autophagy in Disease and Therapy
- Gallbladder and Bile Duct Disorders
- Phagocytosis and Immune Regulation
- Neuroendocrine Tumor Research Advances
- Epigenetics and DNA Methylation
- Esophageal and GI Pathology
- Adenosine and Purinergic Signaling
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Esophageal Cancer Research and Treatment
- MicroRNA in disease regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
Kyushu University
2011-2025
Kumamoto University
2014-2025
Osaka City General Hospital
2019-2021
Osaka Prefectural Medical Center
2019-2021
Beth Israel Deaconess Medical Center
2013-2017
Harvard University
2013-2017
Kyushu University Hospital
2013
Pancreas Centre (Canada)
2005-2013
Japan Society for the Promotion of Science
2010-2012
University of Miyazaki
2007-2009
<h3>Background/Aims</h3> We studied the role of lysyl oxidase-like 2 (LOXL2) in collagen crosslinking and hepatic progenitor cell (HPC) differentiation, therapeutic efficacy a LOXL2-blocking monoclonal antibody on liver fibrosis progression/reversal mice. <h3>Methods</h3> Anti-LOXL2 antibody, control antilysyl oxidase or placebo was administered during thioacetamide (TAA)-induced progression recovery. Therapeutic biliary tested BALB/c.<i>Mdr2−/−</i> 3,5-diethoxycarbonyl-1,4-dihydrocollidine...
Collagen stabilization through irreversible cross-linking is thought to promote hepatic fibrosis progression and limit its reversibility. However, the mechanism of this process remains poorly defined. We studied functional contribution lysyl oxidase (LOX) collagen progression/reversal in vivo using chronic administration LOX inhibitor β-aminopropionitrile (BAPN, or vehicle as control) C57Bl/6J mice with carbon tetrachloride (CCl4)-induced fibrosis. Fibrotic matrix stability was directly...
Clinical Practice Guidelines for Pancreatic Cancer was first published in 2006 by the Japan Pancreas Society, and revised 2009, 2013, 2016, 2019. In July 2022, newly Japanese.For this revision, we developed an entirely new guideline according to Minds Manual Guideline Development 2020, which includes concepts of GRADE-Grading Recommendations Assessment, Development, Evaluation, enable a better understanding current guidelines. Patients public were actively involved both development...
Pancreatic stellate cells (PSC), which are implicated in desmoplasia pancreatic cancer, enhance the malignancy of cancer and confer resistance to established treatments. We investigated whether antifibrotic agent pirfenidone can suppress exert antitumor effects against cancer. Primary PSCs were from tissue obtained during surgery. In vitro, inhibited proliferation, invasiveness, migration a dose-dependent manner. Although supernatants untreated increased (PCC), pirfenidone-treated decreased...
Radiofrequency ablation (RFA) is a potentially curative therapy for hepatocellular carcinoma (HCC). However, incomplete RFA can induce accelerated invasive growth at the periphery. The mechanisms underlying RFA-induced tumor promotion remain largely unexplored. Three human HCC cell lines were exposed to 45°C-55°C 10 minutes, simulating marginal zone of treatment. At 5-12 days post-treatment proliferation, parameters epithelial-mesenchymal transition (EMT), and activation mitogen-activated...
Integrin αvβ6 is rapidly up‐regulated on cells of epithelial lineage during tissue injury, where one its primary functions activation latent transforming growth factor beta 1 (TGFβ1). In human liver cirrhosis, overexpressed by comprising the ductular reaction, and inhibition suppresses experimental biliary fibrosis in rodents. Here, we show that expressed actively proliferating subset hepatic progenitor required for their function vivo vitro through integrin αvβ6‐dependent TGFβ1 activation....
Intratumor bacteria modify the tumor immune microenvironment and influence outcomes of various tumors. Periodontal pathogen Fusobacterium nucleatum has been detected in pancreatic cancer tissues is associated with poor prognosis. However, it remains unclear how F. affects cancer. Here, we compared clinical features colonization tissues. was 15.5% (13/84) patients. The size significantly larger nucleatum-positive group than negative group. To clarify biological effect intratumor on...
Although immune checkpoint blockade (ICB) therapy has proven to be extremely effective at managing certain cancers, its efficacy in treating pancreatic ductal adenocarcinoma (PDAC) been limited. Therefore, enhancing the effect of ICB could improve prognosis PDAC. In this study, we focused on histamine receptor H1 (HRH1) and investigated impact for We assessed HRH1 expression cancer cell (PCC) specimens from PDAC patients through public data analysis immunohistochemical (IHC) staining. The...
Abstract BACKGROUND: Recently, cancer stem cells have been reported as a new therapeutic target in pancreatic well other cancers, but the specific role of these is unknown. METHODS: The authors investigated functional roles CD133 + cells, 1 putative cell candidates cancer. expression was assessed human and lines by quantitative real‐time reverse transcriptase polymerase chain reaction flow cytometry. Next, they compared ability − to proliferate, migrate, invade using 2 lines. In particular,...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma in which microenvironmental (niche) factors promote PDAC progression. In mouse models, reduction of the increased proportion poorly differentiated with a worse prognosis. Here, we aimed to clarify effects on that may define phenotype and induce distinct therapeutic responses.The molecular features based differentiation grade were clarified genome transcriptome analysis using organoids (PDOs). We identified dependency...
Several studies have revealed the diagnostic value of fluorodeoxyglucose-positron emission tomography for breast carcinomas. However, carcinomas display considerable variation in 18F-labeled 2-fluoro-2-deoxy-D-glucose uptake, and few papers reported clinical utility standardized uptake values (SUV). The purpose this study is to investigate relationship between SUV assessed by positron (PET) clinicopathological characteristics carcinoma. We reviewed 52 45 patients presented at our department...
Background Extracellular matrix (ECM) remodeling is predominantly mediated by fibroblasts using intracellular and extracellular pathways. Although it well known that degradation of the ECM proteases derived from cancer cells facilitates cellular invasion, components has not been clarified. The aim this study was to characterize collagen internalization, which initial step pathway in pancreatic cells, light epithelial–mesenchymal transition (EMT). Methodology/Principal Findings We analyzed...