A5103133043- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Cancer Research and Treatments
- Neuroendocrine Tumor Research Advances
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Gut microbiota and health
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- Angiogenesis and VEGF in Cancer
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- Proteoglycans and glycosaminoglycans research
- Helicobacter pylori-related gastroenterology studies
- Telomeres, Telomerase, and Senescence
Chinese University of Hong Kong
2021-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Qingdao Eighth People's Hospital
2022
Chinese University of Hong Kong, Shenzhen
2021
Johns Hopkins Medicine
2020
Johns Hopkins University
2011-2020
Washington University in St. Louis
2020
Cancer Research Center
2011-2020
Jiangsu Cancer Hospital
2017-2020
Due to the poor prognosis of pancreatic cancer, novel diagnostic modalities for early diagnosis and new therapeutic strategy are urgently needed. Recently, microRNA-21 (miR-21) was reported be strongly overexpressed in cancer as well other solid cancers. We investigated functional roles miR-21, which have not been fully elucidated cancer. miR-21 expression assessed cell lines (14 lines, primary cultures normal epithelial cells fibroblasts, a human ductal line) tissue samples (25 tissues 25...
Abstract Background Recently, the microRNA-200 family was reported to affect cancer biology by regulating epithelial mesenchymal transition (EMT). Especially, expression of miR-200c has been shown be associated with upregulating E-cadherin , a gene known involved in pancreatic behavior. However, significance is unknown. Methods In present study, we investigated relationship between and panel 14 cell lines macro-dissected formalin-fixed paraffin-embedded (FFPE) tissue samples obtained from 99...
The standard palliative chemotherapy for pancreatic ductal adenocarcinoma (PDAC) is gemcitabine-based chemotherapy; however, PDAC still presents a major therapeutic challenge. aims of this study were to investigate the expression pattern genes involved in gemcitabine sensitivity resected tissues and determine correlations gene with treatment outcome.We obtained formalin-fixed paraffin-embedded (FFPE) tissue samples from 70 patients PDAC. Of patients, 40 received adjuvant (AC). We measured...
Angiopoietin-1 (Ang1) has been shown to act as an angiogenic promoter in embryonic angiogenesis by promoting vascular branching, pericyte recruitment and endothelial survival. We have investigated the role of Ang1 tumour neovascularization under clinical conditions animal models. The expression breast cancer specimens was analysed using laser-capture microdissection reverse transcriptase-linked polymerase chain reaction (RT-PCR) on RNA isolated from samples. Despite many human cell lines,...
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy. Nanosecond pulsed electric field (nsPEF) new technology destroying tumor cells with non-thermal high voltage using ultra-short pulses. The study's aim was to evaluate the ablation efficacy of nsPEFs human HCC cell lines and metastatic potential xenograft model on BALB/c nude mice. in vivo study showed induced death dose dependent manner. On hepatocellular line (HCCLM3) mice model, growth inhibited significantly nsPEF-treated-...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, hence a major public health threat. Pleomorphic adenoma gene like-2 (PLAGL2) has been reported to play role in tumorigenesis. However, its precise function HCC remains poorly understood.In this study, we demonstrated that PLAGL2 was up-regulated compared with adjacent nontumorous tissues and also correlated overall survival times. We further showed promoted cell proliferation, migration, invasion...
Pancreatic ductal adenocarcinoma is often characterized by an abundant desmoplastic stroma that partially induced activated pancreatic stellate cells (PSCs). Indirect co-culture has been used to investigate the effects of cancer-stromal interactions on proliferation cancer cells, but cell-cell adhesion and juxtacrine signaling between stromal cannot be evaluated using this method. This study aimed establish a simplified direct system could quantify populations in with PSCs, evaluate cell...
Abstract Purpose: Intraductal papillary mucinous neoplasms (IPMN) are precursors to infiltrating pancreatic ductal adenocarcinomas. Widespread epigenetic alterations characteristic of many cancers, yet few studies have systematically analyzed neoplastic precursors. Our goal was conduct genome-wide CpG island methylation profiling identify aberrantly methylated loci in IPMNs. Experimental Design: We compared the profiles six IPMNs normal primary duct samples using amplification (MCA) and...
Liver cancer, particularly hepatocellular carcinoma (HCC), is one of leading causes cancer-related mortality worldwide. Upregulation the evolutionary conserved Hippo signaling pathway has been observed in HCC patients, and Yes-associated protein 1 (YAP1) reported to play a key role tumorigenesis. microRNAs (miRNAs) are family small non-coding RNAs, usually 21-25 nucleotides length, essential regulation gene expression. Abnormal miRNA expression implicated initiation progression numerous...
Abstract The angiopoietin-1 (Ang1)/Tie2 signaling pathway is known to play an important role in the regulation of vascular maturation and maintenance vessel integrity. In this study, we have investigated effect systemic Tie2 activation or inhibition on tumor growth metastasis. We found that treatment with Ang1 delivered via adenoviral vector promoted s.c. implanted metastasis lungs. did not significantly increase density tumors but induced enlargement blood vessels both normal tissues, which...
Giant congenital melanocytic nevi (CMNs) are at an increased risk for malignant transformation. To explore the mutation frequencies of BRAFV600E (V-raf murine sarcoma virus oncogene homolog B1) and NRAS (neuroblastoma ras viral homolog) codon 61 in CMNs Chinese, we selected 55 paraffin-embedded tissue blocks, including 37 cases medium (1.5-20cm) 18 giant (>20 cm). Direct sequencing was performed to detect mutations. The mutations were detected 9 (16.4%). In CMNs, (24.3%) detected. Notably,...
To define frequencies, pattern of progression (invasive vs noninvasive), and risk factors resected noninvasive intraductal papillary mucinous neoplasms (IPMNs).There is a in the remnant pancreas after resection IPMNs.Four hundred forty-nine consecutive patients with IPMNs from 1995 to 2018 were included study. Patients invasive carcinoma or follow-up <6 months excluded. Noninvasive was defined as new IPMN, increased main pancreatic duct size, size an existing lesion (5 mm compared...
Tris(1,3-dichloro-2-propyl)phosphate (TDCPP) is an environmental contaminant that has attracted increasing concern due to its presence in media and biological samples. Our previous study demonstrated exposure TDCPP reduced the lifespan of Caenorhabditis elegans, but mechanisms, including relevant signaling pathways, are unclear. The current found triggers unconventional insulin/insulin-like growth factor (IIS) pathway, not by disrupting insulin-like factor-1 receptor DAF-2/IGF1R inhibiting...
Nowadays, microRNA-375 (miR-375) has been implicated in many types of cancers, including hepatocellular carcinoma (HCC), and the functions miRNAs encapsulated by extracellular vesicles (EV) HCC progression have also extensively investigated. In this research, we aimed to probe into mechanism EV-encapsulated miR-375 from bone marrow-derived mesenchymal stem cells (BM-MSCs) progression. At first, expression tissues was detected using RT-qPCR, overexpressed specify effects on malignant...