A5102879629- Cancer-related molecular mechanisms research
- Aquaculture disease management and microbiota
- Risk and Safety Analysis
- Advanced Graph Neural Networks
- Toxic Organic Pollutants Impact
- Traffic and Road Safety
- Immune Cell Function and Interaction
- Genomics, phytochemicals, and oxidative stress
- Autonomous Vehicle Technology and Safety
- Traffic control and management
- Invertebrate Immune Response Mechanisms
- Nanoparticles: synthesis and applications
- Traffic Prediction and Management Techniques
- Domain Adaptation and Few-Shot Learning
- Microplastics and Plastic Pollution
- CAR-T cell therapy research
- Autophagy in Disease and Therapy
- Topic Modeling
- Gut microbiota and health
- Air Quality and Health Impacts
- Inflammasome and immune disorders
- RNA modifications and cancer
- Effects and risks of endocrine disrupting chemicals
- Plant Stress Responses and Tolerance
- MicroRNA in disease regulation
Zhejiang A & F University
2024-2025
Liaoning Cancer Hospital & Institute
2023-2025
China Medical University
2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2025
Shanghai University of Traditional Chinese Medicine
2025
Chengdu University of Traditional Chinese Medicine
2023-2024
Beijing University of Technology
2022-2024
Zhejiang University
2022-2024
Sanya University
2023-2024
Xijing Hospital
2024
Abstract Background Somatic embryogenesis (SE), by which somatic cells of higher plants can dedifferentiate and reorganize into new plants, is a notable illustration cell totipotency. However, the precise molecular mechanisms regulating SE remain unclear. To characterize events this unique process, transcriptome analysis, in combination with biochemical histological approaches, were conducted cotton, typical plant species SE. Genome-wide profiling gene expression allowed identification novel...
Triple-negative breast cancer (TNBC) is an aggressive subtype for which effective therapies are lacking.Epidermal growth factor receptor (EGFR) overexpressed in various types of TNBC cells, and several EGFR-specific immunotherapies have been used to treat patients.Chimeric antigen engineered T (CAR-T) cells also as therapies.In this study, we generated two CAR-modified using lentiviral vectors with DNA sequences encoding the scFv regions anti-EGFR antibodies.The cytotoxic antitumor effects...
Abstract Objectives Traditional cancer therapy and regular immunotherapy are ineffective for treating triple‐negative breast (TNBC) patients. Recently, chimeric antigen receptor‐engineered natural killer cells (CAR NK) have been applied to target several hormone receptors on different improve the efficacy of immunotherapy. Furthermore, epidermal growth factor receptor (EGFR) is a potential therapeutic TNBC. Here, we demonstrated that EGFR‐specific CAR NK (EGFR‐CAR cells) could be potentially...
Unsupervised spatial representation learning aims to automatically identify effective features of geographic entities (i.e., regions) from unlabeled yet structural geographical data. Existing network embedding methods can partially address the problem by: (1) regarding a region as node in order reformulate into embedding; (2) graph embedding. However, these studies be improved by preserving intra-region structures, which are represented multiple graphs, leading reformulation collective...
Summary The drought caused by global warming seriously affects the crop growth and agricultural production. Plants have evolved distinct strategies to cope with environment. Under stress, energy resources should be diverted from toward stress management. However, molecular mechanism underlying coordination of response remains largely elusive. Here, we discovered that most gibberellin (GA) metabolic genes were regulated water scarcity in rice, leading lower GA contents hence inhibited plant...
Abstract Bone metastasis is the most happened metastatic event in prostate cancer (PCa) and needs a large effort treatment. When PCa metastasizes to bone, new microenvironment can induce epigenome reprogramming stemness remodeling of cells, thereby increasing adaptability cells bone microenvironment, this even leads occurrence secondary tumor metastasis. Our group has previously found that RNA binding motif 3 (RBM3) affects stem cell-like properties by interfering with alternative splicing...
Microplastics pollution is becoming a global environmental concern, and growing evidence has demonstrated the accumulation distribution of microplastics in terrestrial ecosystems. Once entering into soil, can change physical, chemical biological properties then affect growth plants. Currently, most attentions have focused on toxic effects plants, only very limited report showed uptake by higher plants under hydroponic culture conditions. The nutrient solution useful understanding mechanism...
Accurate and proactive lane-changing (LC) intention recognition can assist drivers in making LC decisions to improve driving safety. However, the mechanism of drivers' dynamically changing environments is still not fully understood, which makes it difficult for advanced driver-assistance systems (ADASs) make accurate under different working conditions. To accurately capture dynamic features before generation intention, relying on multivehicle interaction capability connected environment, a...
Sound knowledge of the local distribution and diversity freshwater snail intermediate hosts factors driving occurrence abundance them is crucial to understanding snail-borne parasitic disease transmission setting up effective interventions in endemic areas. In this study, we investigated snails, water quality parameters, physical characteristics habitats, predators competitors, human activity variables at 102 sites during December 2018 August 2019 Shenzhen adjacent areas China. We used...
Oil and gas pipelines, as vital arteries for energy transportation, play a crucial role in ensuring the supply of energy. However, under harsh geological conditions external forces, pipeline's anti-corrosion layer is susceptible to damage, particularly destruction caused by forces such rockfall. This study focuses on performance new type material-Fiber Reinforced Polymer (FRP) coating-under rockfall scratch, compares it with Polyethylene (3PE) coating. By establishing three-dimensional...
In recent years, graph pre-training has gained significant attention, focusing on acquiring transferable knowledge from unlabeled data to improve downstream performance. Despite these endeavors, the problem of negative transfer remains a major concern when utilizing pre-trained models tasks. Previous studies made great efforts issue what pre-train and how by designing variety fine-tuning strategies. However, there are cases where even most advanced "pre-train fine-tune" paradigms fail yield...
Background Gastric cancer (GC) is one of the primary causes cancer-related fatalities, which requires novel treatment including traditional Chinese medicine (TCM) to prolong survival. Protocatechualdehyde (PCA), a monomer from herbs, exhibits an anti-cancer effect by inhibiting proliferation and migration, or inducing apoptosis in various types tumors. However, underlying mechanism PCA gastric are still unclear. Methods The cell ability was detected counting kit-8 (CCK-8) colony formation....