A5100671948- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Nanoplatforms for cancer theranostics
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Photodynamic Therapy Research Studies
- Genomics, phytochemicals, and oxidative stress
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- DNA and Nucleic Acid Chemistry
- Animal Genetics and Reproduction
- Advanced biosensing and bioanalysis techniques
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
Shanghai University
2016-2025
Hebei General Hospital
2025
Institute of Environmental Engineering
2025
Gansu Provincial Center for Disease Control and Prevention
2025
Siemens (China)
2012-2024
Dalian University
2018-2024
Dalian University of Technology
2018-2024
Royal Women's Hospital
2024
Hebei University of Science and Technology
2024
Sichuan University
2008-2023
The most common working mechanism of photodynamic therapy is based on high-toxicity singlet oxygen, which called Type II therapy. But it highly dependent oxygen consumption. Recently, I has been found to have better hypoxia tolerance ease this restriction. However, few strategies are available the design photosensitizers. We herein report an unexpected strategy alleviate limitation traditional by biotinylation three photosensitizers (two fluorescein-based and commercially Protoporphyrin)....
Type I photosensitization provides an effective solution to the problem of unsatisfactory photodynamic therapeutic (PDT) effects caused by tumor hypoxia. The challenge in development mode is boost photosensitizer's own electron transfer capacity. Herein, we found that use bovine serum albumin (BSA) encapsulate a thermally activated delayed fluorescence (TADF) photosensitizer PS can significantly promote PDT process generate mass superoxide anions (O2•–). This opened new strategy employing...
Abstract Background When DNA double-strand breaks (DSB) are induced by ionizing radiation (IR) in cells, histone H2AX is quickly phosphorylated into γ-H2AX (p-S139) around the DSB site. The necessity of DNA-PKcs regulating phosphorylation response to damage and cell cycle progression was investigated. Results level γH2AX HeLa cells increased rapidly with a peak at 0.25 - 1.0 h after 4 Gy γ irradiation. SiRNA-mediated depression resulted strikingly decreased γH2AX. An also ATM deficient line...
In order to elucidate the cytotoxicity of organophosphate flame retardants (OPFRs), three human in vitro models, namely HepG2 hepatoma cells, A549 lung cancer cells and Caco-2 colon were chosen investigate toxicity triphenyl phosphate (TPP), tributylphosphate (TBP), tris(2-butoxyexthyl) (TBEP) tris (2-chloroisopropyl) (TCPP). Cytotoxicity was assayed terms cell viability, DNA damage status, reactive oxygen species (ROS) level lactate dehydrogenase (LDH) leakage. The results showed that all...
Abstract Tumor hypoxia is a typical characteristic of tumor microenvironment (TME), which seriously compromises the therapeutic effect photodynamic therapy (PDT). The development nanozymes with oxygen‐generation ability promising strategy to overcome oxygen‐dependent PDT but remained great challenge. Herein, dual‐nanozymes based cascade reactor HAMF proposed alleviate for enhanced PDT. hollow mesoporous silica nanoparticles (HMSNs) are constructed as an excellent nanocarrier load ultra‐small...
Purpose This study aimed to quantitatively investigate two main magnetization transfer effects at low B 1 : the nuclear Overhauser enhancement (NOE) and amide proton in human brain 7 T. Methods The were characterized using a four‐pool model, which consisted of bulk water, macromolecules, an group mobile proteins peptides, NOE‐related protons resonating upfield. pool sizes, exchange rates, relaxation times these pools investigated by fitting, net signals NOE simulated based on fitted...
Mitochondria-targeting photodynamic therapy (PDT) can block mitochondrial function and trigger the inherent proapoptotic cascade signal of mitochondria, which has been considered to have potential amplify efficiency PDT. However, dynamic change membrane (MMP) makes most cationic photosensitizers easily fall off from greatly limits Here, we developed a smart liposome encapsulation method based on mitochondria-stapling photosensitizer for efficient theranostic therapy. The stapling be...
Micro- and nano- polystyrene particles have been widely detected in environment, posing potential threats to human health. This study was designed evaluate the neurodevelopmental toxicity of nanoparticles (NPs) Caenorhabditis elegans (C. elegans), screen crucial genes investigate underlying mechanism. In wild-type C. elegans, NPs (diameter 50 nm) could concentration-dependently induce significant inhibition body length, survival rate, head thrashes, bending, accompanying with increase...
Abstract Background C-Myc is a short-lived oncoprotein that destroyed by ubiquitin-mediated proteolysis. Dysregulated accumulation of c-Myc commonly occurs in human cancers. Some those cases with the dysregulated protein are attributed to gene amplification or increased mRNA expression. However, abnormal also common finding cancers normal copy number and transcription level gene. It seems mechanistic dysregulation control stabilization another important hallmark associated cancer cells. Here...
We investigated the effects of hexabromocyclododecanes (HBCDs) at environmentally relevant concentrations on human L02 hepatocytes and explored possible underlying molecular mechanism(s), focusing functional interactions between phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) nuclear factor-erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathways. The results showed that low HBCDs could stimulate cell proliferation in a "DNA-dependent protein catalytic subunit"...
Hybrid liposome/metal nanoparticles are promising candidate drug-carriers for therapy of various diseases due to their unique photothermal effect. In this study, self-crystallized gold (Au NPs) and doxorubicin (DOX) were co-encapsulated within liposomes (Au/DOX-Lips) by thin film hydration gel separation technology. The surface plasmon resonance bands controllable in the near-infrared (NIR) zone. When complex liposome/metallic hybrids irradiated NIR light, they displayed higher endocytosis...
The cysteine protease ATG4B is a key component of the autophagy machinery, acting to proteolytically prime and recycle its substrate MAP1LC3B. roles in cancer other diseases appear be context dependent but are still not well understood. To help further explore functions potential therapeutic applications, we employed chemical biology approach identify inhibitors. Here, describe discovery 4-28, styrylquinoline identified by combined computational modeling, silico screening, high content...