A5007302696- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Metabolism, Diabetes, and Cancer
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Folate and B Vitamins Research
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- RNA Research and Splicing
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Mitochondrial Function and Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal Cancer Research and Treatment
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
Kyushu University Beppu Hospital
2014-2023
The University of Tokyo
2022
Japanese Red Cross Medical Center
2022
Tokyo University of Science
2022
The Cancer Institute Hospital
2022
Fukuoka City Hospital
2022
Kyushu University
2012-2021
Kagoshima University
2016
Fukuoka Children's Hospital and Medical Center for Infectious Diseases
2013
Saiseikai Fukuoka General Hospital
2012
Abstract Fructose-1,6-bisphosphatase (FBP1), the rate-limiting enzyme in gluconeogenesis, is reduced expression certain cancers where it has been hypothesized to act as a tumor suppressor, including hepatocellular carcinoma (HCC). Here, we report functional evidence supporting this hypothesis, providing preclinical rationale develop FBP1 therapeutic target for HCC treatment. Three independent cohorts totaling 594 cases of were analyzed address clinical significance. Lower associated with...
Advanced colorectal cancer harbors extensive intratumor heterogeneity shaped by neutral evolution; however, in precancerous lesions has been poorly studied. We perform multiregion whole-exome sequencing on ten early tumors, which contained adenoma and carcinoma situ. By comparing with data from advanced we show that the tumors accumulate a higher proportion of subclonal driver mutations than is highlighted KRAS APC. also demonstrate variant allele frequencies tend to be suggesting are...
Abstract We previously developed γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) as a tool to detect viable cancer cells, based on the fact that enzyme γ-glutamyltranspeptidase (GGT) is overexpressed membranes of various but not expressed in normal tissue. Cleavage probe by GGT generates fluorescence. Here, we examined feasibility clinical application gGlu-HMRG during breast-conserving surgery. found fluorescence derived from cleavage allowed easy discrimination breast tumors, even...
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignancies owing to high frequency tumor recurrence. The identification markers for early ESCC diagnosis and prediction recurrence expected improve long-term prognosis. Therefore, we searched associations between cell-free DNA (cfDNA) mutations in blood plasma, which contains genetic various cancer types.Genomic from tumors cfDNA plasma were obtained 13 patients undergoing treatment newly diagnosed ESCC....
MicroRNA-29b (miR-29b) targets numerous important genes that mediate carcinogenesis and tumor development in breast cancer vitro vivo. The aim of the present study was to determine clinical significance miR-29b expression primary patients. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) certain target miR-29b, such as DNA methyltransferase 3A (DNMT3A), ten-eleven translocation 1 (TET1) thymine glycosylase (TDG), performed 94 samples. Low tumors significantly associated...
Amplification of chromosome 7p (Ch.7p) is common in colorectal cancer (CRC). The aim this study was to identify potential driver genes on Ch.7p that are overexpressed due DNA copy number amplification and determine their clinical significance CRC.We identified phosphoserine phosphatase (PSPH) as a gene using CRC dataset from Cancer Genome Atlas (TCGA) bioinformatics approach. expression PSPH 124 primary CRCs examined by quantitative reverse transcription polymerase chain reaction (PCR)...
miR-146a plays important roles in cancer as it directly targets NUMB, an inhibitor of Notch signaling. is reportedly regulated by a G>C polymorphism (SNP; rs2910164). This affects various cancers, including colorectal (CRC). However, the clinical significance CRC remains unclear. A total 59 patients with were divided into 2 groups: CC/CG genotype (n = 32) and GG 27), based on polymorphism. cDNA microarray analysis was performed using samples. Significantly enriched gene sets each extracted...
Sentinel lymph node biopsy is performed as a standard procedure in breast cancer surgery, and the development of quick simple methods to detect metastatic lesions high demand. Here, we validated new fluorescent method using γ-glutamyl hydroxymethyl rhodamine green diagnose nodes cancer. One hundred forty-nine from 38 patients were evaluated this study. Comparison pathological images showed that was successful for visualizing cells nodes. This had sufficiently sensitivity (97%), specificity...
<b><i>Objective:</i></b> MOB1, a core component of the Hippo signaling pathway, suppresses cell proliferation, and MOB1 liver conditional knockout mice develop intrahepatic cholangiocarcinoma (ICC). However, its clinical significance in human ICC has not been established. The aim this study was to characterize protein levels role TGF pathways ICCs. <b><i>Methods:</i></b> yes-associated 1 (YAP1), Smad2, TGFβ2 88 cases were analyzed. Protein...
Few driver genes have been well established in esophageal squamous cell carcinoma (ESCC). Identification of the genomic aberrations that contribute to changes gene expression profiles can be used predict genes.We searched for ESCC by integrative analysis microarray and copy number data. To narrow down candidate genes, we performed survival on data tested genetic vulnerability each using public RNAi screening We confirmed results performing experiments evaluating clinical relevance an...
Background/Aim: SLC9A9 plays an oncogenic role in esophageal squamous carcinoma and glioblastoma. Herein, we showed function of colorectal cancer (CRC). Materials Methods: We examined expression CRC specimens by immunohistochemistry. In tissues, the relationship between clinicopathological factors was further elucidated quantitative real-time polymerase chain reaction (qRT-PCR) gene set enrichment analysis (GSEA). vitro, performed knockdown overexpression experiments. Results: overexpressed...
<b><i>Objective:</i></b> The involvement of epithelial-mesenchymal transition (EMT) in esophageal squamous cell carcinoma (ESCC) has not been fully elucidated. Here, we aimed to identify EMT-related genes associated with TGF-β ESCC and clarify the role these progression ESCC. <b><i>Methods:</i></b> expression were identified patients using microarray analysis public datasets. effects ubiquitin-like PHD ring finger domains 2 (UHRF2) analyzed...